Controlling type 2 diabetes mellitus with herbal medicines: A triple‐blind randomized clinical trial of efficacy and safety

Mirfeizi, Mani; Tourzani, Zahra Mehdizadeh; Mirfeizi, Seyedeh Zahra; Jafarabadi, Mohammad Asghari; Rezvani, Hamid; Afzali, Mohammad H.

doi:10.1111/1753-0407.12342

Cited by 66 publications

(65 citation statements)

References 24 publications

(72 reference statements)

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“…However, on administration of 50, 150 and 300 mg/kg of ethanolic leaves extracts to the diabetic mice, lipid profile level was found to be restored and turned to words normal level ( Table 4) and results were comparable with results reported earlier by Del et al 7 . Significant reduction in levels of ALT, AST and ALP were found in animals treated with ethanolic leaves extracts ( Table 5).…”

Section: Discussionsupporting

confidence: 90%

“…Furthermore phytotherapeutics are not alternatives but part of modern medicines. Medical doctor prescribes both synthetic drugs and phytotherapeutics and patients takes medicines to regain their health 7 . The significance of plant based medicines have been increased all over the world and about 50 % medicines available in the markets are made up by plants based active ingredients whose alternative cannot yet be prepared synthetically 8 .…”

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confidence: 99%

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2016

IJPSR

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ABSTRACT:Very little knowledge about use of papaya leaves is available in the literature, the leaves of papaya are bitter to taste which explains its therapeutic benefits. The present study was undertaken to assess anti diabetic effects of leaves extracts of Carica Papaya and Glucophage on streptozotocin -induced diabetic mice. Results indicates that hyperglycemic level in diabetic mice was normalized after administration of various doses (50, 150 and 300 mg/kg bw) of ethanolic leaves extracts to diabetic mice. Similarly leaves extracts of C. Papaya have also shown pronounced effects on plasma insulin, triglyceride, cholesterol and HDL cholesterol levels. The levels of liver enzymes (ALT, AST and ALP), bilirubin and blood cells (Red cells, white cells and platelets) were improved on dose depended manner. Analysis of various leaves extracts for phytochemicals revealed presence of significant amount of alkaloids, steroid, tannins, total phenols and flavonoids. It is assumed that biologically active components of papaya leaf extracts are helpful in decreasing secondary complications of diabetes and improved insulin sensitivity to uptake glucose by cells. Which also indicates that these extracts might be good source of pharmaceutical materials need for preparation of various drugs required for human health.

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Section: Discussionsupporting

confidence: 90%

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confidence: 99%

Untitled

2016

IJPSR

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“…The majority of the studies used cinnamon powder in the form of capsule (17 studies) (Akilen et al, ; Aldayel, ; Askari et al, ; Azimi et al, ; Blevins et al, ; Borzoei et al, ; Gupta Jain et al, ; Haghighian et al, ; Hajimonfarednejad et al, ; Mirfeizi et al, ; Nakhaei et al, ; Shishehbor et al, ; Soni & Bhatnagar, ; Torabi et al, ; Vafa et al, ; Wainstein et al, ; Zare et al, ), and the four remaining studies used the cinnamon extract (Anderson et al, ; Talaat & Ammar, ; Weitgasser et al, ; Ziegenfuss et al, ). The 11 trials were conducted in individuals with T2DM (Akilen et al, ; Azimi et al, ; Blevins et al, ; Haghighian et al, ; Mirfeizi et al, ; Soni & Bhatnagar, ; Torabi et al, ; Vafa et al, ; Wainstein et al, ; Weitgasser et al, ; Zare et al, ), and the other trials included women with polycystic ovarian syndrome (PCOS) (three trials) (Borzoei et al, ; Hajimonfarednejad et al, ; Talaat & Ammar, ), participants with overweight (two trials) (Aldayel, ; Nakhaei et al, ), MetS and prediabetes (three trials) (Anderson et al, ; Gupta Jain et al, ; Ziegenfuss et al, ), nonalcoholic fatty liver disease (NAFLD) (one trials) (Askari et al, ), and rheumatoid arthritis (RA) (one trial) (Shishehbor et al, ). In general, the administered dose of cinnamon for these included trials ranged between 336 mg/d of cinnamon extract to 10,000 mg/day of cinnamon powder.…”

Section: Resultsmentioning

confidence: 99%

“…Although several studies have supported the anti‐obesity effect of cinnamon (Aldayel, ; Gupta Jain et al, ; Mirfeizi et al, ; Zare, Nadjarzadeh, Zarshenas, Shams, & Heydari, ; Ziegenfuss, Hofheins, Mendel, Landis, & Anderson, ), the others have led to conflicting results (Askari, Rashidkhani, & Hekmatdoost, ; Azimi, Ghiasvand, Feizi, Hariri, & Abbasi, ; Talaat & Ammar, ; Wainstein, Stern, Heller, & Boaz, ; Weitgasser et al, ). A recent meta‐analysis indicated that cinnamon might not have a significant impact on body weight, waist circumference (WC), and body mass index (BMI) (Namazi et al, ) in patients with type 2 diabetes mellitus.…”

Section: Introductionmentioning

confidence: 99%

Effects of cinnamon supplementation on body weight and composition in adults: A systematic review and meta‐analysis of controlled clinical trials

Yazdanpanah

Azadi-Yazdi

Hooshmandi

et al. 2019

Phytotherapy Research

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Background This systematic review and meta‐analysis aimed to investigate the effect of cinnamon on body weight, body mass index (BMI), waist circumference (WC), waist–hip ratio (WHR), and body fat mass including the maximum number of studies. Methods Medline, ISI Web of Science, Scopus, Google Scholar, and Cochrane library were searched with no limitation from inception up to August 2019 for relevant randomized controlled clinical trials (RCTs). The RCTs' risk of bias was assessed using the Cochrane collaboration's tool. Random‐effects model was used for meta‐analysis. Results Twenty‐one RCTs with 1,480 participants were included. The meta‐analysis showed that cinnamon supplementation significantly reduces BMI [weighted mean difference (WMD) = −0.40 kg/m2, 95% confidence interval (CI): −0.57, −0.22 kg/m2, p < .001, I2 = 78.9%], body weight (WMD = −0.92 kg; 95% CI: −1.51, −0.33 kg; p = .002; I2 = 84.2%), and WHR (WMD = −0.02, 95% CI: −0.038, −0.018; p < 0.001; I2 = 0%). Cinnamon supplementation did not significantly affect the WC (WMD = −1.76 cm, 95% CI: −3.57, −0.045 cm; p = .056; I2 = 90.8%) and body fat mass (WMD = −0.87%, 95% CI: −1.87, 0.025%; p = .057; I2 = 78.6%). Conclusion Cinnamon supplementation significantly reduces body weight, BMI, and WHR. Future high‐quality long‐term RCTs are recommended to confirm these results.

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“…This review includes 11 RCTs 21, 23, 25-27, 33-38 , three of which, Mirfeiz and colleagues 36 , Vafa and colleagues 37 , and Sharma and colleagues 38 had not been included in the meta-analyses noted above. A total of 694 subjects (both placebo and cinnamon treatment) were enrolled across 11 individual RCTs with 15 treatment arms.…”

Section: Studies Included In This Reviewmentioning

confidence: 99%

Do Cinnamon Supplements Have a Role in Glycemic Control in Type 2 Diabetes? A Narrative Review

Costello¹,

Dwyer²,

Saldanha³

et al. 2016

Journal of the Academy of Nutrition and Dietetics

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Cinnamon (Cinnamomum sp.) has been suggested to help patients with type 2 diabetes mellitus (T2DM) achieve better glycemic control although conclusions from meta-analyses are mixed. To evaluate whether the use of cinnamon dietary supplements by adults with T2DM had clinically meaningful effects on glycemic control, as measured by changes in fasting plasma glucose (FPG) or hemoglobin A1c (HbA1c), a comprehensive PubMed literature search was performed. Eleven RCTs were identified meeting our inclusion criteria that enrolled 694 adults with T2DM receiving hypoglycemic medications or not. In 10 of the studies participants continued to take their hypoglycemic medications during the cinnamon intervention period. Studies ranged from 4 to 16 weeks in duration; seven studies were double-blinded. Cinnamon doses ranged from 120 to 6000 mg/d. The species of cinnamon used varied; 7 used C. cassia/C. aromaticum; 1 used C. zeylanicum, and 3 did not disclose it. Because of the heterogenity of the studies, a metaanalysis was not conducted. All 11 of the studies reported some reductions in FPG during the cinnamon intervention, and of the studies measuring HbA1c very modest decreases were also apparent with cinnamon, while changes in the placebo groups were minimal. However, only four studies achieved the American Diabetes Association treatment goals (FPG <7.2 mmol/L or 130 mg/dL and/or HbAlc <7.0). We conclude that cinnamon supplements added to standard hypoglycemic medications and other lifestyle therapies had modest effects on FPG and HbA1c. Until larger and more rigorous studies are available, dietitians and other healthcare professionals should recommend that patients continue to follow existing recommendations of authoritative bodies for diet, lifestyle changes, and hypoglycemic drugs.

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Controlling type 2 diabetes mellitus with herbal medicines: A triple‐blind randomized clinical trial of efficacy and safety

Cited by 66 publications

References 24 publications

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Effects of cinnamon supplementation on body weight and composition in adults: A systematic review and meta‐analysis of controlled clinical trials

Do Cinnamon Supplements Have a Role in Glycemic Control in Type 2 Diabetes? A Narrative Review

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