Controlled trial of d-cycloserine adjuvant therapy for treatment-resistant major depressive disorder

Ketamine and Other NMDA Antagonists: Early Clinical Trials and Possible Mechanisms in Depression

“…However, additional evidence suggests a more complex pharmacology, confirming that D-cycloserine acts as a partial agonist at glycine binding sites present on GluN2A, GluN2B, and GluN2D subunits of the NMDA receptor, but as a full agonist at glycine binding sites on GluN2C subunits (109,110). The literature search identified two randomized clinical trials of D-cycloserine treatment of depression (see Table S2 in the data supplement), both published by the same group (111,112). The two studies used widely divergent oral D-cycloserine doses, 250 mg (111) versus 1,000 mg (112) per day.…”

The role of glutamate in mood disorders: Results from the ketamine in major depression study and the presumed cellular mechanism underlying its antidepressant effects

“…Preclinical studies of cycloserine in mood disorders show antidepressant-like properties in rodent models of depression [34][35][36]. However, a recent double-blind, placebo-controlled, 6-week crossover study involving 22 patients with treatmentresistant MDD found that D-cycloserine at 250 mg/d, when added to other antidepressants, was ineffective in treatment-resistant MDD [37]; however, it is possible that the doses studied were too low.…”

Augmenting Transcranial Direct Current Stimulation With D-Cycloserine for Depression

“…In a small, placebo-controlled trial of 22 patients with major depression receiving Cycloserine as adjuvant therapy to antidepressants, 24 there was no statistically significant difference between Cycloserine and placebo with regard to improvement in mood as measured by the Hamilton Depression Rating Scale and the Zung Self-Rating Depression Scale. This is consistent with the lack of facilitating effects on extinction of conditioned fear observed in rats that were exposed to imipramine for 14 days before receiving a single dose of Cycloserine before fear extinction training.…”