Controlled Release of Plectasin NZ2114 from a Hybrid Silicone-Hydrogel Material for Inhibition of Staphylococcus aureus Biofilm

Klein, Kasper; Grønnemose, Rasmus Birkholm; Alm, Martin; Brinch, Karoline Sidelmann; Kolmos, Hans Jørn; Andersen, Thomas Emil

doi:10.1128/aac.00604-17

Cited by 19 publications

(23 citation statements)

References 14 publications

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“…Due to limitations in the manufacturing process, the IPN concepts explored in the latter are often microscale particle based. As we recently showed, IPN can, however, also be manufactured as a non-degradable base material in flexible medical devices, providing a reservoir in the bulk of the material for controlled release of drugs (Stenger et al, 2016;Klein et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

“…They have been explored over the past 80 years as components in drug carrier systems and found use in microscale capsule-based formulations and biodegradable implants that enable site-specific controlled drug delivery (Changez et al, 2004(Changez et al, , 2005Lohani et al, 2014;Aminabhavi et al, 2015). Recently, we showed that IPNs could also successfully be incorporated into silicone-based medical devices, essentially converting the device bulk material into a drug reservoir while maintaining device functionality (Stenger et al, 2016;Klein et al, 2017). This provides a conceptual alternative solution to the current challenges of designing anti-infective coatings (Myung et al, 2008;Stenger et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

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A Novel Device-Integrated Drug Delivery System for Local Inhibition of Urinary Tract Infection

et al. 2021

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Background: Catheter-associated urinary tract infection (CAUTI) is a frequent community-acquired infection and the most common nosocomial infection. Here, we developed a novel antimicrobial catheter concept that utilizes a silicone-based interpenetrating polymer network (IPN) as balloon material to facilitate a topical slow-release prophylaxis of antibacterial agents across the balloon to the urinary bladder.Methods: The balloon material was achieved by modifying low shore hardness silicone tubes with a hydrogel interpenetrating polymer in supercritical CO2 using the sequential method. Release properties and antibacterial efficacy of the IPN balloon treatment concept was investigated in vitro and in a porcine CAUTI model developed for the study. In the latter, Bactiguard Infection Protection (BIP) Foley catheters were also assessed to enable benchmark with the traditional antimicrobial coating principle.Results: Uropathogenic Escherichia coli was undetectable in urinary bladders and on retrieved catheters in the IPN treatment group as compared to control that revealed significant bacteriuria (>105 colony forming units/ml) as well as catheter-associated biofilm. The BIP catheters failed to prevent E. coli colonization of the bladder but significantly reduced catheter biofilm formation compared to the control.Conclusion: The IPN-catheter concept provides a novel, promising delivery route for local treatment in the urinary tract.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Novel Device-Integrated Drug Delivery System for Local Inhibition of Urinary Tract Infection

et al. 2021

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“…[109][110][111] While commercial development was halted, preclinical studies are actively ongoing with promising results. [112][113][114][115][116] Oragenics (Tampa, FL, USA) has investigated…”

Section: Systemic Antibioticsmentioning

confidence: 99%

Overview of Host Defense Peptides and Their Applications for Plastic and Reconstructive Surgeons

DeLong

Tandon

Lio

et al. 2020

Plastic &Amp; Reconstructive Surgery

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Background: Host defense peptides are a family of endogenous short peptides that are found in all living beings and play a critical role in innate immunity against infection. Methods: A nonsystematic review of host defense peptides was conducted with specific interest in properties and applications relevant to plastic and reconstructive surgery. Results: In addition to their direct antimicrobial actions against pathogens, including multidrug-resistant bacteria, they also demonstrate important functions in immunomodulation, tumor cell lysis, and tissue regeneration. These properties have made them a topic of clinical interest for plastic surgeons because of their potential applications as novel antibiotics, wound healing medications, and cancer therapies. The rising clinical interest has led to a robust body of literature describing host defense peptides in great depth and breadth. Numerous mechanisms have been observed to explain their diverse functions, which rely on specific structural characteristics. However, these peptides remain mostly experimental, with limited translation to clinical practice because of numerous failures to achieve acceptable results in human trials. Conclusions: Despite the broad ranging potential of these peptides for use in the field of plastic and reconstructive surgery, they are rarely discussed in the literature or at scientific meetings. In this review, the authors provide a summary of the background, structure, function, bacterial resistance, and clinical applications of host defense peptides with the goal of stimulating host defense peptide–based innovation within the field of plastic and reconstructive surgery.

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“…Human defensin peptides themselves are unlikely to be developed into therapeutics because of their well-described functional versatility 115–119. A derivative of the fungal defensin plectasin, termed NZ2114, has shown most promise to date, with in vivo efficacy in infectious models as well as applications to combat biofilm formation 120–122. Similar to the plectasin study, we identified C-terminal hydrophobic residues Ile20 and Leu25 of Human Neutrophil Peptide-1 to be mainly involved in Lipid II binding.…”

Section: Introductionmentioning

confidence: 99%

<p>Therapeutic compounds targeting Lipid II for antibacterial purposes</p>

Malin

Leeuw

2019

IDR

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Resistance against commonly used antibiotics has emerged in all bacterial pathogens. In fact, there is no antibiotic currently in clinical use against which resistance has not been reported. In particular, rapidly increasing urbanization in developing nations are sites of major concern. Additionally, the widespread practice by physicians to prescribe antibiotics in cases of viral infections puts selective pressure on antibiotics that still remain effective and it will only be a matter of time before resistance develops on a large scale. The biosynthesis pathway of the bacterial cell wall is well studied and a validated target for the development of antibacterial agents. Cell wall biosynthesis involves two major processes; 1) the biosynthesis of cell wall teichoic acids and 2) the biosynthesis of peptidoglycan. Key molecules in these pathways, including enzymes and precursor molecules are attractive targets for the development of novel antibacterial agents. In this review, we will focus on the major class of natural antibacterial compounds that target the peptidoglycan precursor molecule Lipid II; namely the glycopeptides, including the novel generation of lipoglycopeptides. We will discuss their mechanism-of-action and clinical applications. Further, we will briefly discuss additional peptides that target Lipid II such as the lantibiotic nisin and defensins. We will highlight recent developments and future perspectives.

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Controlled Release of Plectasin NZ2114 from a Hybrid Silicone-Hydrogel Material for Inhibition of Staphylococcus aureus Biofilm

Cited by 19 publications

References 14 publications

A Novel Device-Integrated Drug Delivery System for Local Inhibition of Urinary Tract Infection

A Novel Device-Integrated Drug Delivery System for Local Inhibition of Urinary Tract Infection

Overview of Host Defense Peptides and Their Applications for Plastic and Reconstructive Surgeons

<p>Therapeutic compounds targeting Lipid II for antibacterial purposes</p>

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