Controlled release of Mitomycin C from modified cellulose based thermo-gel prevents post-operative de novo peritoneal adhesion

Sultana, Tamanna; Hải, Hồ Văn Minh; Park, Myeongki; Lee, Sun-Young; Lee, Byong‐Taek

doi:10.1016/j.carbpol.2019.115552

Cited by 28 publications

(20 citation statements)

References 56 publications

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“…In a rat model of cecal abrasion, de novo adhesions were effectively prevented and reperitonealization was also observed [405]. The efficacy of this hydrogel can likely be attributed to the combination of a physical barrier with MMC, which is reported to upregulate TNF-α, and downregulate collagen and fibronectin gene expression, although the specific cellular effects require elucidation [405]. Similar prevention of pericardial adhesions was seen in a rat model of post-operative adhesions [406].…”

Section: Integrated Pharmaceuticals In Barriersmentioning

confidence: 88%

“…MMC is a DNA alkylating antitumor antibiotic, which inhibits in vitro fibroblast proliferation with anti-fibrinolytic activity [404]. In a rat model of cecal abrasion, de novo adhesions were effectively prevented and reperitonealization was also observed [405]. The efficacy of this hydrogel can likely be attributed to the combination of a physical barrier with MMC, which is reported to upregulate TNF-α, and downregulate collagen and fibronectin gene expression, although the specific cellular effects require elucidation [405].…”

Section: Integrated Pharmaceuticals In Barriersmentioning

confidence: 99%

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Prevention of Post-Operative Adhesions: A Comprehensive Review of Present and Emerging Strategies

et al. 2021

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Post-operative adhesions affect patients undergoing all types of surgeries. They are associated with serious complications, including higher risk of morbidity and mortality. Given increased hospitalization, longer operative times, and longer length of hospital stay, post-surgical adhesions also pose a great financial burden. Although our knowledge of some of the underlying mechanisms driving adhesion formation has significantly improved over the past two decades, literature has yet to fully explain the pathogenesis and etiology of post-surgical adhesions. As a result, finding an ideal preventative strategy and leveraging appropriate tissue engineering strategies has proven to be difficult. Different products have been developed and enjoyed various levels of success along the translational tissue engineering research spectrum, but their clinical translation has been limited. Herein, we comprehensively review the agents and products that have been developed to mitigate post-operative adhesion formation. We also assess emerging strategies that aid in facilitating precision and personalized medicine to improve outcomes for patients and our healthcare system.

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Section: Integrated Pharmaceuticals In Barriersmentioning

confidence: 88%

Section: Integrated Pharmaceuticals In Barriersmentioning

confidence: 99%

Prevention of Post-Operative Adhesions: A Comprehensive Review of Present and Emerging Strategies

et al. 2021

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“…Curcumin‐loaded hydrogels prepared by this method were used as wound dressing materials which can promote wound healing and reduce bacterial infection via releasing curcumin. In Figure 11B, Lee and colleagues 87 developed thermosensitive hydrogel barrier by combining mitomycin C (MMC) with modified tempo oxidized nanocellulose (cTOCN) via hydrogen bonds followed by integration with methyl cellulose (MC). The MMC was successfully combined with cTOCN and ensured controlled release of MMC from hydrogels throughout 14 days.…”

Section: Properties and Applicationsmentioning

confidence: 99%

Cellulose‐based hydrogels regulated by supramolecular chemistry

Zeng

Sun

et al. 2021

SusMat

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Supramolecular hydrogels based on cellulose attract increasing attention because of their novel structures and broad potential applications. In this review, hydrogels composed of cellulose are summarized according to category of supramolecular interactions in the networks including hydrogen bonds, electrostatic interactions, host‐guest interactions, and others. Supramolecular cellulose‐based hydrogels constructed by noncovalent bonding usually exhibit environmental friendliness, designing flexibility and diverse functions, and their properties are variable with incorporating different interactions in hydrogel networks. Moreover, with proper structures and networks, the supramolecular cellulose‐based hydrogels are adaptable in diverse fields of research and practical applications, such as self‐healing, shape memory, drug delivery, and some other renewable/sustainable materials. The future developments and challenges of the supramolecular hydrogels based on cellulose are discussed as well.

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“…Their disadvantages are thus related to the biomaterials used [ 70 ]. Several studies have applied various biomaterials and technologies to establish anti-adhesion barriers [ 26 , 27 , 37 , 38 , 71 , 72 ]. These anti-adhesion biomaterials have excellent biocompatibility and biodegradability [ 73 , 74 ] and can be classified as either natural or synthetic polymers.…”

Section: Polymers As Materials For Anti-adhesion Barriersmentioning

confidence: 99%

“…Recently, a thermosensitive hydrogel was developed to apply an anti-adhesion barrier, even in surgery, using the minimally invasive method. Thermosensitive anti-adhesion barriers have the advantage that they can be applied to surgical sites through injection because they are liquid at room temperature and gel at body temperature [ 27 , 32 , 146 , 147 ].…”

Section: Various Strategies Of Anti-adhesionmentioning

confidence: 99%

Biomaterials to Prevent Post-Operative Adhesion

et al. 2020

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Surgery is performed to treat various diseases. During the process, the surgical site is healed through self-healing after surgery. Post-operative or tissue adhesion caused by unnecessary contact with the surgical site occurs during the normal healing process. In addition, it has been frequently found in patients who have undergone surgery, and severe adhesion can cause chronic pain and various complications. Therefore, anti-adhesion barriers have been developed using multiple biomaterials to prevent post-operative adhesion. Typically, anti-adhesion barriers are manufactured and sold in numerous forms, such as gels, solutions, and films, but there are no products that can completely prevent post-operative adhesion. These products are generally applied over the surgical site to physically block adhesion to other sites (organs). Many studies have recently been conducted to increase the anti-adhesion effects through various strategies. This article reviews recent research trends in anti-adhesion barriers.

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Controlled release of Mitomycin C from modified cellulose based thermo-gel prevents post-operative de novo peritoneal adhesion

Cited by 28 publications

References 56 publications

Prevention of Post-Operative Adhesions: A Comprehensive Review of Present and Emerging Strategies

Prevention of Post-Operative Adhesions: A Comprehensive Review of Present and Emerging Strategies

Cellulose‐based hydrogels regulated by supramolecular chemistry

Biomaterials to Prevent Post-Operative Adhesion

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