Controlled preparation and properties of porous poly(l-lactide) obtained from a co-continuous blend of two biodegradable polymers

Preparation of interconnected poly(ε-caprolactone) porous scaffolds by a combination of polymer and salt particulate leaching

“…More recently, a new methodology for the preparation of porous scaffolds for tissue engineering has emerged from the melt blending of two immiscible polymers [37,38].T h e strategy used consists in melt blending the two polymers in the judicious composition required to create the so-called cocontinuous blend morphology, an interconnected structure in which each phase is fully continuous. At dispersed phase content beyond the percolation point (y15 vol%), the minor phase starts to form elongated structures that can touch to create an interconnected network.…”

Effect of salt leaching on PCL and PLGA(50/50) resorbable scaffolds

“…In the field of tissue reconstructions, the pore sizes are related with the cell type. Determining the best size range of the pore represents one of the important focuses of researches in tissue engineering scaffolds 24 . It has been reported fibroblast growth on scaffolds with pore sizes between 5 and 15 µm 25 , hepatocytes on approximately 20 µm…”

“…In bone tissue engineering, the pore sizes vary between 100 and 400 µm 24 . DSC analyses of PCL samples are characteristic of a semi crystalline polymer while PLGA50 samples are typical of amorphous materials, identified by the presence of Tg and by the absence of Tm ( Table 1).…”

Tissue Engineering for Tissue and Organ Regeneration

“…Within solid polymers, poly lactic acid (PLA), poly glycolic acid (PGA) and copolymers (PLGA) have been broadly used in tissue engineering as well as for cartilage regeneration (Anderson and Langone, 1999;Babensee et al, 2000;Chu et al, 1997;Honda et al, 2000;Sarazin et al, 2004). These biomaterials are approved by the food and drug administration (FDA) as they activate a minimal or mild foreign body reaction, and as such are considered biocompatible.…”