Controlled Photoinitiated Release of Nitric Oxide from Polymer Films Containing <i>S</i>-Nitroso-<i>N</i>-acetyl-<scp>dl</scp>-penicillamine Derivatized Fumed Silica Filler

Frost, Megan C.; Meyerhoff, Mark E.

doi:10.1021/ja039466i

Cited by 114 publications

(109 citation statements)

References 20 publications

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“…the lower wavelength, results of previous studies suggest that photodecomposition of RSNOs is primarily the result of light absorption in the 550 -600 nm region (10 ). The light effect can be expected to be much greater for plasma samples, given the lack of any shielding from light offered by the presence of red blood cells.…”

Section: Discussionmentioning

confidence: 93%

Photoinstability of S-Nitrosothiols during Sampling of Whole Blood: A Likely Source of Error and Variability in S-Nitrosothiol Measurements

Zhang

Wang

et al. 2008

Clinical Chemistry

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BACKGROUND:The determination of reference intervals for the concentration of total S-nitrosothiols (RSNOs) in blood is a highly controversial topic, likely because of the inherent instability of these species. Most currently available techniques to quantify RSNOs in blood require considerable sample handling and multiple pretreatment steps during which light exposure is difficult to completely eliminate. We investigated the effect of brief light exposure on the stability of RSNO species in blood during the initial sampling process.

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Section: Discussionmentioning

confidence: 93%

Photoinstability of S-Nitrosothiols during Sampling of Whole Blood: A Likely Source of Error and Variability in S-Nitrosothiol Measurements

Zhang

Wang

et al. 2008

Clinical Chemistry

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“…[2] Especially in the field of cancer therapy, NO not only directly kills cancerous cells at high concentrations (> 1 mm) through the nitrosation of mitochondria and DNA, [3] but also cooperatively enhances the efficacy of photodynamic therapy or radiotherapy.…”

Section: Asanalternativetochemotherapytheemerginggastherapymentioning

confidence: 99%

Glucose‐Responsive Sequential Generation of Hydrogen Peroxide and Nitric Oxide for Synergistic Cancer Starving‐Like/Gas Therapy

et al. 2016

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Glucose is a key energy supplier and nutrient for tumor growth. Herein, inspired by the glucose oxidase (GOx)-assisted conversion of glucose into gluconic acid and toxic H O , a novel treatment paradigm of starving-like therapy is developed for significant tumor-killing effects, more effective than conventional starving therapy by only cutting off the energy supply. Furthermore, the generated acidic H O can oxidize l-Arginine (l-Arg) into NO for enhanced gas therapy. By using hollow mesoporous organosilica nanoparticle (HMON) as a biocompatible/biodegradable nanocarrier for the co-delivery of GOx and l-Arg, a novel glucose-responsive nanomedicine (l-Arg-HMON-GOx) has been for the first time constructed for synergistic cancer starving-like/gas therapy without the need of external excitation, which yields a remarkable H O -NO cooperative anticancer effect with minimal adverse effect.

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“…Cu + ), or light irradiation at the energies that correspond to the S-nitroso absorption bands at 340 and/or 590 nm. [42][43][44][45] The spontaneous decomposition reaction of RSNOs (no redox reaction) yields a disulfide (RSSR) product and NO. In these catheters the NO release from the SNAP-doped E2As polymer is initiated by the heat and moisture when the devices are placed in the flowing blood.…”

Section: In Vitro No Release From Catheters and Effects Of Ethylene Omentioning

confidence: 99%

Reduction in thrombosis and bacterial adhesion with 7 day implantation of S-nitroso-N-acetylpenicillamine (SNAP)-doped Elast-eon E2As catheters in sheep

et al. 2015

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Thrombosis and infection are two common problems associated with blood-contacting medical devices such as catheters. Nitric oxide (NO) is known to be a potent antimicrobial agent as well as an inhibitor of platelet activation and adhesion. Healthy endothelial cells that line the inner walls of all blood vessels exhibit a NO flux of 0.5~4×10 −10 mol cm −2 min −1 that helps prevent thrombosis. Materials with a NO flux that is equivalent to this level are expected to exhibit similar anti-thrombotic properties. In this study, NO-releasing catheters were fabricated by incorporating S-nitroso-N-acetylpenicillamine (SNAP) in the Elast-eon E2As polymer. The SNAP/E2As catheters release physiological levels of NO for up to 20 d, as measured by chemiluminescence. Furthermore, SNAP is stable in the E2As polymer, retaining 89% of the initial SNAP after ethylene oxide (EO) sterilization. The SNAP/E2As and E2As control catheters were implanted in sheep veins for 7 d to examine the effect on thrombosis and bacterial adhesion. The SNAP/E2As catheters reduced the thrombus area when compared to the control (1.56 ± 0.76 and 5.06 ± 1.44 cm 2 , respectively). A 90% reduction in bacterial adhesion was also observed for the SNAP/E2As catheters as compared to the controls. The results suggest that the SNAP/E2As polymer has the potential to improve the hemocompatibility and bactericidal activity of intravascular catheters, as well as other blood-contacting medical devices (e.g., vascular grafts, extracorporeal circuits).

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Controlled Photoinitiated Release of Nitric Oxide from Polymer Films Containing S-Nitroso-N-acetyl-dl-penicillamine Derivatized Fumed Silica Filler

Cited by 114 publications

References 20 publications

Photoinstability of S-Nitrosothiols during Sampling of Whole Blood: A Likely Source of Error and Variability in S-Nitrosothiol Measurements

Photoinstability of S-Nitrosothiols during Sampling of Whole Blood: A Likely Source of Error and Variability in S-Nitrosothiol Measurements

Glucose‐Responsive Sequential Generation of Hydrogen Peroxide and Nitric Oxide for Synergistic Cancer Starving‐Like/Gas Therapy

Reduction in thrombosis and bacterial adhesion with 7 day implantation of S-nitroso-N-acetylpenicillamine (SNAP)-doped Elast-eon E2As catheters in sheep

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