Controlled formation of vesicles with added styrene and their fixation by polymerization

Yalçınkaya, Hacer; Bressel, Katharina; Lindner, Peter; Gradzielski, Michael

doi:10.1016/j.jcis.2018.07.097

Cited by 5 publications

(5 citation statements)

References 47 publications

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“…Previous work has revealed that adding LiPFOS to a mixture of TDMAO/L35 leads to the formation of vesicles with a hydrodynamic radius ( R h ) of 36 nm. , When we analyzed the DLS curves in Figure b, the same values were deduced for the initial sample, that is, at zero monomer concentration. Upon loading the HA monomer to the vesicles, the R h decreased to ∼20–26 nm (see Table ) but retained the low PDI of 0.06–0.1 (see Figure S18).…”

Section: Resultssupporting

confidence: 61%

“…Upon loading the HA monomer to the vesicles, the R h decreased to ∼20–26 nm (see Table ) but retained the low PDI of 0.06–0.1 (see Figure S18). Molecular weights, M w app , were deduced from static LS (SLS) measurements, and the resulting aggregation numbers are in agreement with previous reports . The radius of gyration R g gained from the angular dependence of the SLS and R h are also close in value as for hollow spheres thereby yielding a consistent structural picture.…”

Section: Resultsmentioning

confidence: 99%

“…Molecular weights, M wd app , were deduced from static LS (SLS) measurements, and the resulting aggregation numbers are in agreement with previous reports. 31 The radius of gyration R g gained from the angular dependence of the SLS and R h are also close in value as for hollow spheres…”

Section: Formation Of Monomer-loadedmentioning

confidence: 99%

“…For our experiments, we chose a system with 1 mol % L35, where small (radius of 35 nm), monodisperse [polydispersity index (PDI) of 0.06], and kinetically stabilized vesicles are obtained (but the size could be easily varied by the amount of polymer added). Recently, we showed that this vesicle system can be used as a template for styrene polymerization, and vesicle structures could be retained with keeping the average size but for rather high polydispersity. A big advantage of this system is the ease with which it can be formed, which is a simple mixing of two low-viscous surfactant solutions.…”

Section: Introductionmentioning

confidence: 99%

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Polymeric Nanocapsules from Well-Defined Zwitanionic Vesicles as a Template

et al. 2022

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Polymeric nanocapsules have application in versatile fields, thus they have drawn much attention in the past decade. Preparing a homogeneous, uniform, small nanocapsule system is challenging and requires further improvement. A powerful way for realizing controlled synthesis of these submicron structures is by initiating them from a vesicular basis. Herein, we report the formation of highly monodisperse and rather small polymeric nanocapsules originating from a well-defined self-assembled surfactantbased system. In our approach, a monomer is initially dissolved in surfactant micelles, which are transformed spontaneously into well-defined vesicles upon mixing with a second surfactant solution. Subsequently, the monomer-loaded vesicles become polymerized via UV-initiated polymerization, where different amounts of monomers and cross-linkers are employed. The whole process is characterized in detail by light scattering and small-angle neutron scattering (SLS, DLS, and SANS) analyses. The final product of small, unilamellar, highly monodisperse polymeric nanocapsules has potential for applications with entrapping the cargo either in the aqueous core or in the hydrophobic membrane.

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Section: Resultssupporting

confidence: 61%

Section: Resultsmentioning

confidence: 99%

Section: Formation Of Monomer-loadedmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Polymeric Nanocapsules from Well-Defined Zwitanionic Vesicles as a Template

et al. 2022

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“…The extreme thinness of the shell makes detection and identification of the thickness signature difficult, but we now have an understanding of the SANS signature. Furthermore, we were able to measure the increase of the measured thickness due to coating with surfactant, which enables accurate subtraction to determine the thickness of the polymer shells alone in samples that are stabilized with surfactants, something previous studies were unable to do. − We have exploited these methods to investigate the relationship between the structure of bilayer-templated nanocapsules and their functional performance. A combination of SANS along with other methods allowed us to set the goals for this study.…”

Section: Introductionmentioning

confidence: 99%

Deciphering and Controlling Structural and Functional Parameters of the Shells in Vesicle-Templated Polymer Nanocapsules

et al. 2019

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Vesicle-templated nanocapsules are prepared by polymerization of hydrophobic acrylic monomers and cross-linkers in the hydrophobic interior of self-assembled bilayers. Understanding the mechanism of capsule formation and the influence of synthetic parameters on the structural features and functional performance of nanocapsules is critical for the rational design of functional nanodevices, an emerging trend of application of the nanocapsule platform. This study investigated the relationship between basic parameters of the formulation and synthesis of nanocapsules and structural and functional characteristics of the resulting structures. Variations in the monomer/surfactant ratio, temperature of polymerization, and the molar fraction of the free-radical initiators were investigated with a multipronged approach, including shell thickness measurements using small-angle neutron scattering, evaluation of the structural integrity of nanocapsules with scanning electron microscopy, and determination of the retention of entrapped molecules using absorbance and fluorescence spectroscopy. Surprisingly, the thickness of the shells did not correlate with the monomer/surfactant ratio, supporting the hypothesis of substantial stabilization of the surfactant bilayer with loaded monomers. Decreasing the temperature of polymerization had no effect on the spherical structure of nanocapsules but resulted in progressively lower retention of entrapped molecules, suggesting that a spherical skeleton of nanocapsule forms rapidly, followed by filling the gaps to create the structure without pinholes. Lower content of initiators resulted in slower reactions, outlining the baseline conditions for practical synthetic protocols. Taken together, these findings provide insights into the formation of nanocapsules and offer methods for controlling the properties of nanocapsules in viable synthetic methods.

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