1986
DOI: 10.1093/ije/15.4.572
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Abstract: Two controlled, double blind field trials of a non-living promastigote vaccine against New World Cutaneous Leishmaniasis (NWCL) were conducted in 1981 and 1983 in Brazil. Brazilian Army conscripts were randomly assigned to the vaccine or placebo groups and tested during their training in the Amazon jungle, a high risk area for NWCL. The results obtained showed: no significant differences between the vaccine and the placebo groups with respect to a number of characteristics (age, race, previous contact with the… Show more

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Cited by 129 publications
(47 citation statements)
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“…The observations that protective immunity against Leishmania infection can be acquired in susceptible mice (23,25,34,(48)(49)(50) as well as in humans (2,19,37) have indicated the possibility for the development of a vaccine against leishmaniasis. In mice, studies of protection against cutaneous leishmaniasis have been observed after immunization with promastigote-derived molecules such as lipophosphoglycan, gp63, defined gp63 epitopes, and gp46 (also known as M-2) (8,20,24,32,45,49,50,58,59).…”
mentioning
confidence: 99%
“…The observations that protective immunity against Leishmania infection can be acquired in susceptible mice (23,25,34,(48)(49)(50) as well as in humans (2,19,37) have indicated the possibility for the development of a vaccine against leishmaniasis. In mice, studies of protection against cutaneous leishmaniasis have been observed after immunization with promastigote-derived molecules such as lipophosphoglycan, gp63, defined gp63 epitopes, and gp46 (also known as M-2) (8,20,24,32,45,49,50,58,59).…”
mentioning
confidence: 99%
“…Moreover, results from our laboratory (19) on vaccination of human volunteers with a crude promastigote leishmanial vaccine have shown that the majority of the Leishmania-responding T cells in assays of the lymphoproliferative response to the parasite antigen presented a CD8 + phenotype and IFN-γ production. In this case the CD8 + T cell response seems to be involved in the mechanisms of protective immunity since there is evidence that the vaccine is able to induce protection in approximately 50% of cases (20). b) CD8 + T cells may play an important role in the cure of leishmaniasis by producing type 1 lymphokines, leading to the activation of macrophages for parasite destruction.…”
mentioning
confidence: 99%
“…Preparation of candidate vaccines -The candidate vaccine preparations used in this study were produced using a well defined WHO reference Leishmania amazonensis strain (IFLA/BR/67/PH8) in the Departamento de Parasitologia, Instituto de Ciências Biológicas (ICB), Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil, according to a methodology described in detail elsewhere (Mayrink et al 1979, Antunes et al 1986, De Luca et al 1999, Armijos et al 2004. Briefly, promastigotes of L. amazonensis IFLA/BR/67/PH8 were grown in liver infusion medium and harvested at stationary phase (7 days of culture) using centrifugation.…”
Section: Subjects Materials and Methodsmentioning
confidence: 99%