Controlled drug release system based on cyclodextrin-conjugated poly(lactic acid)-b-poly(ethylene glycol) micelles

Novel worm-like amphiphilic micelles of folate-targeted cyclodextrin/retinoic acid for delivery of doxorubicin in KG-1 cells

“…Although the high PDI values (around 0.4) are seen in formulations prepared by α-CD however, in all micelles obtained from β-CD and also in the optimized formulation (PDI=0.28) it was less than 0.3 which is quite ideal and an acceptable value for polydispersity index and indicates low diversity of the particle size. The suitable PDI of 0.2 is also reported in many works of copolymeric micellar drug delivery systems like cyclodextrin-conjugated poly(lactic acid)-b-poly(ethylene glycol) micelles [10].…”

“…Among CDs, β-CD is the most accessible because it has low toxicity, certain hydrophilicity, low cost, good biocompatibility, and biodegradability. β-CD is used as drug carrier in controlled release systems [9][10][11][12], for example an amphiphilic biodegradable copolymer is synthesized from poly(γ-benzyl L-glutamate) (PBLG) as the hydrophobic segment and β-CD as the hydrophilic site of the micelles of β-CD-PBLG [13].…”

One-pot synthesis of water-soluble, β-cyclodextrin-based polyrotaxanes in a homogeneous water system and its use in bio-applications

“…1 H NMR, 2D DOSY and 2D NOESY spectra were recorded with a Bruker DRX 500 NMR spectrometer using either CDCl 3 or DMSO-d 6 as the solvent and with tetramethylsilane (TMS) as the internal standard. The morphology of the product was studied with HR-TEM on a JEM-2100 electron microscope at 120 KV.…”

“…[1][2][3][4] The cyclic molecules can be a-, b-and g-cyclodextrin (CD), which are approved by the FDA as food additives and as drug formulations. 5,6 CDs can rotate and/or slide along a linear chain in the PRs, and the mobility of ligands linked by the CDs play a key role in enhancing multivalent interactions with biomacromolecules (for example, receptor proteins). 7 The low cytotoxicity, controllable size and unique architecture of CD-based PRs have opened up new possibilities for drug delivery, gene delivery, tissue engineering and biosensor applications.…”

Cyclodextrin-based star polymers as a versatile platform for nanochemotherapeutics: Enhanced entrapment and uptake of idarubicin

“…It has been reported that self-assembled micelles based on CDconjugated poly(lactic acid)-b-poly(ethylene glycol) amphiphilic copolymer ensured controlled release of indomethacin. This suggests that the introduction of CD provided an effective secondary functional unit to normal micelles, thus contributing to the controlled drug release with decreased initial burst [34]. On the other hand, acrylic acid derivatives including PMMA are among the most frequently used polymers for nanoparticle preparation.…”