Controlled Delivery of High vs Low Humidity vs Mist Therapy for Croup in Emergency Departments

Abstract

ClinicalTrials.gov Identifier: NCT00230841.

Efficacy of nebulized L‐epinephrine for treatment of croup: a randomized, double‐blind study

“…There are limited studies focusing on efficacy of nebulized L-epinephrine. The results of our study were in agreement with previous findings [6,9]. We showed that from a total of 69 patients with mild croup, L-epinephrine caused a significant reduction in the score of disease in 52% of patients.…”

Efficacy of nebulized L‐epinephrine for treatment of croup: a randomized, double‐blind study

“…There are limited studies focusing on efficacy of nebulized L-epinephrine. The results of our study were in agreement with previous findings [6,9]. We showed that from a total of 69 patients with mild croup, L-epinephrine caused a significant reduction in the score of disease in 52% of patients.…”

Pediatric respiratory distress: California out‐of‐hospital protocols and evidence‐based recommendations

“…Mist or humidified oxygen therapy in patients with stridor is not recommended with level A recommendation against its use. One Cochrane systematic review with 3 ED studies with 135 patients total and 2 randomized controlled trials involving 71 and 140 patients found that mist therapy is ineffective for improving respiratory distress in pediatric patients with croup 16–18 …”

Humidified air inhalation for treating croup: a systematic review and meta-analysis

“…5 Glucocorticoid treatment is beneficial in mild croup and led to significantly earlier discharge from the ED and lower admission rates in the week following treatment. 17 In contrast it appears that treatment with 12 humidified air might lead to an increased risk of admission, albeit with wide CIs.…”

Efficacy of nebulized L‐epinephrine for treatment of croup: a randomized, double‐blind study

“…There are limited studies focusing on efficacy of nebulized L-epinephrine. The results of our study were in agreement with previous findings [6,9]. We showed that from a total of 69 patients with mild croup, L-epinephrine caused a significant reduction in the score of disease in 52% of patients.…”

Pediatric respiratory distress: California out‐of‐hospital protocols and evidence‐based recommendations

“…Mist or humidified oxygen therapy in patients with stridor is not recommended with level A recommendation against its use. One Cochrane systematic review with 3 ED studies with 135 patients total and 2 randomized controlled trials involving 71 and 140 patients found that mist therapy is ineffective for improving respiratory distress in pediatric patients with croup 16–18 …”

Humidified air inhalation for treating croup: a systematic review and meta-analysis

“…5 Glucocorticoid treatment is beneficial in mild croup and led to significantly earlier discharge from the ED and lower admission rates in the week following treatment. 17 In contrast it appears that treatment with 12 humidified air might lead to an increased risk of admission, albeit with wide CIs.…”

Efficacy of nebulized L‐epinephrine for treatment of croup: a randomized, double‐blind study

“…There are limited studies focusing on efficacy of nebulized L-epinephrine. The results of our study were in agreement with previous findings [6,9]. We showed that from a total of 69 patients with mild croup, L-epinephrine caused a significant reduction in the score of disease in 52% of patients.…”

Pediatric respiratory distress: California out‐of‐hospital protocols and evidence‐based recommendations

“…Mist or humidified oxygen therapy in patients with stridor is not recommended with level A recommendation against its use. One Cochrane systematic review with 3 ED studies with 135 patients total and 2 randomized controlled trials involving 71 and 140 patients found that mist therapy is ineffective for improving respiratory distress in pediatric patients with croup 16–18 …”

Humidified air inhalation for treating croup: a systematic review and meta-analysis

“…5 Glucocorticoid treatment is beneficial in mild croup and led to significantly earlier discharge from the ED and lower admission rates in the week following treatment. 17 In contrast it appears that treatment with 12 humidified air might lead to an increased risk of admission, albeit with wide CIs.…”