Controlled Comparison of Tianeptine, Alprazolam and Mianserin in the Treatment of Adjustment Disorders with Anxiety and Depression

A Systematic Review of Psychological and Pharmacological Treatments for Adjustment Disorder in Adults

“…One European RCT that involved Belgian, Swiss, and French participants ( N = 152) compared tianeptine, a psychotropic compound with both antidepressant and anxiolytic potentials, with both an antidepressant (mianserin) and an anxiolytic (alprazolam) for the treatment of patients with adjustment disorder with mixed emotional features (Ansseau et al., ). Results indicated that the three treatments had similar efficacy in reducing anxiety and depression.…”

Adjustment disorder with anxiety in old age: Comparing prevalence and clinical management in primary care and mental health care

“…Pharmacological management also differed between the two care settings. Few controlled trials have been conducted on the pharmacological management of adjustment disorders, but some data support the effectiveness of both antidepressants and tranquilisers [1]. Among tranquilisers, non-benzodiazepine compounds, such as etifoxine, seem to be as effective as benzodiazepines [29].…”

Neurobiology of mood, anxiety, and emotions as revealed by studies of a unique antidepressant: tianeptine

“…It rapidly alleviates anxious symptoms of depressed patients 34,39,[41][42][43][44][45][46] with no sedative-associated effects. 47 Tianeptine and other antidepressants share some common effects such as those on neurogenesis.…”