Controlled cell proliferation and immortalization of human dental pulp stem cells with a doxycycline‐inducible expression system
Ai Orimoto,
William N. Addison,
Shinichi Mochizuki
et al.
Abstract:Human dental pulp stem cells are a potentially useful resource for cell‐based therapies and tissue repair in dental and medical applications. However, the primary culture of isolated dental pulp stem cells has notably been limited. A major requirement of an ideal human dental pulp stem cell culture system is the preservation of efficient proliferation and innate stemness over prolonged passaging, while also ensuring ease of handling through standard, user‐friendly culture methods. In this study, we have engine… Show more
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