Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

1
14
0

Year Published

2016
2016
2018
2018

Publication Types

Select...
5
2
1

Relationship

0
8

Authors

Journals

citations
Cited by 21 publications
(15 citation statements)
references
References 184 publications
1
14
0
Order By: Relevance
“…In agreement with its neuroprotective role, in this study we show that PINK1 disruption causes enhanced excitatory transmission, which might precede excitotoxicity and consequent hippocampal neuropathology in PD (Hall et al, ). This neuroprotective role is also in agreement with several lines of evidence indicating that PINK1 can protect cells also from other types of stressors, including proteasomal inhibition, oxidative stress, mitochondrial blockers and apoptotic inducers (Mills et al, ; Matic et al, ; Strappazzon and Cecconi, ). For these reasons, targeting PINK1 pathway might be of therapeutic interest not only in PD and other neurodegenerative conditions (Khalil et al, ; Chin and Li, ), but also in peripheral disorders (Williams and Ding, ).…”
Section: Discussionsupporting
confidence: 89%
“…In agreement with its neuroprotective role, in this study we show that PINK1 disruption causes enhanced excitatory transmission, which might precede excitotoxicity and consequent hippocampal neuropathology in PD (Hall et al, ). This neuroprotective role is also in agreement with several lines of evidence indicating that PINK1 can protect cells also from other types of stressors, including proteasomal inhibition, oxidative stress, mitochondrial blockers and apoptotic inducers (Mills et al, ; Matic et al, ; Strappazzon and Cecconi, ). For these reasons, targeting PINK1 pathway might be of therapeutic interest not only in PD and other neurodegenerative conditions (Khalil et al, ; Chin and Li, ), but also in peripheral disorders (Williams and Ding, ).…”
Section: Discussionsupporting
confidence: 89%
“…Amyotrophic lateral sclerosis (ALS) is an incurable, chronic progressive neurodegenerative disease characterized by the degeneration of upper motor neurons in the motor cortex and lower motor neurons in the spinal cord and the brain stem [ 142 ]; the reason why only motor neurons are targeted remains unknown. ALS results in loss of power and function of skeletal muscles, which is reflected by difficulties in walking, using the arms, speaking and swallowing.…”
Section: Role Of Vitamin C In Neurodegenerative Diseasesmentioning
confidence: 99%
“…An emerging and promising approach to treating these diseases leverages their sensitivity to activation of the master regulator of antioxidant and cytoprotective genes and their products, namely, nuclear factor (erythroid-derived 2)-like 2/antioxidant response element (Nrf2/ARE), and mitophagy [Osborne et al, 2014;Pagano et al, 2014;Palikaras and Tavernarakis, 2014;Johnson and Johnson, 2015;Joshi et al, 2015;Matic et al, 2015;Nikoletopoulou et al, 2015;Prasad, 2015;Rai et al, 2015;Denzer et al, 2016;Moos et al, 2016;Suliman and Piantadosi, 2016].…”
Section: Introductionmentioning
confidence: 99%