Contrôle du développement embryonnaire par des petits ARN issus de transposons

Papin, Catherine; Simonelig, Martine

doi:10.1051/medsci/20112712004

Cited by 2 publications

(3 citation statements)

References 9 publications

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“…1 b). Such results suggested the potential role of TEs as promoters in mouse tissue development as previously reported [ 7 , 19 – 24 , 46 – 51 ]. Approximately 10% of accessible TEs were commonly accessible in all five tissues (Fig.…”

Section: Resultssupporting

confidence: 88%

“…Specifically, the intact transcriptional elements of TEs can create novel transcription start sites (TSSs) to initiate transcription in the host genome. These novel TSSs were found to be the origination of a large proportion long non-coding RNAs [ 24 , 46 , 48 , 50 , 51 , 66 ] and also created novel transcript isoforms of conserved protein-coding genes during evolution [ 8 , 17 , 20 , 37 , 74 , 75 ].…”

Section: Discussionmentioning

confidence: 99%

“…Our study identified 453 accessible TE-derived 5′ end TSSs across the five tissues, and most of these TE-derived TSSs were validated by independent CAGE-seq data generated by the FANTOM5 project [ 73 , 88 ]. Previous studies reported that TEs were major contributors to the origin of non-coding RNAs [ 24 , 46 – 51 ]. In addition to confirming TE’s contribution to lincRNA, our results revealed a crucial evolutionary mechanism by which TEs contributed significantly to evolving alternative transcription start sites for protein-coding genes and, in some cases, to evolving novel tissue-specific expression patterns for these genes.…”

Section: Discussionmentioning

confidence: 99%

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Tissue-specific usage of transposable element-derived promoters in mouse development

Miao

Lyu

et al. 2020

Genome Biol

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Background Transposable elements (TEs) are a significant component of eukaryotic genomes and play essential roles in genome evolution. Mounting evidence indicates that TEs are highly transcribed in early embryo development and contribute to distinct biological functions and tissue morphology. Results We examine the epigenetic dynamics of mouse TEs during the development of five tissues: intestine, liver, lung, stomach, and kidney. We found that TEs are associated with over 20% of open chromatin regions during development. Close to half of these accessible TEs are only activated in a single tissue and a specific developmental stage. Most accessible TEs are rodent-specific. Across these five tissues, 453 accessible TEs are found to create the transcription start sites of downstream genes in mouse, including 117 protein-coding genes and 144 lincRNA genes, 93.7% of which are mouse-specific. Species-specific TE-derived transcription start sites are found to drive the expression of tissue-specific genes and change their tissue-specific expression patterns during evolution. Conclusion Our results suggest that TE insertions increase the regulatory potential of the genome, and some TEs have been domesticated to become a crucial component of gene and regulate tissue-specific expression during mouse tissue development.

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