1980
DOI: 10.1073/pnas.77.7.4331
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Abstract: Angiogenesis and tumor growth were inhibited in two different animal models by regional infusion of a partially purified cartilage extract. In rabbits bearing corneal implants of V2 carcinoma and receiving the inhibitor, vascular growth rates were <3% of those in control animals receiving either Ringer's solution or bovine trypsin inhibitor (Trasylol). Subconjunctival B16 melanoma implants-in mice receiving the inhibitor weighed <2.5% of implants in mice receiving Ringer's solution, Trasylol, or albumin. Histp… Show more

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Cited by 140 publications
(58 citation statements)
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“…It is well known [45] that tumors undergo the process of angiogenesis when they reach about 0.3 cm in diameter, at which time blood vessels are recruited from the surrounding tissue and a growth surge occurs. However, results of [64]- [66] show that the necrotic fraction and hypoxic fraction increase with the volume of vascularized tumors, and blood vessels are densest at the tumor periphery and are absent in the necrotic core.…”
Section: Wein 16mentioning
confidence: 99%
“…It is well known [45] that tumors undergo the process of angiogenesis when they reach about 0.3 cm in diameter, at which time blood vessels are recruited from the surrounding tissue and a growth surge occurs. However, results of [64]- [66] show that the necrotic fraction and hypoxic fraction increase with the volume of vascularized tumors, and blood vessels are densest at the tumor periphery and are absent in the necrotic core.…”
Section: Wein 16mentioning
confidence: 99%
“…1 Cartilaginous tissues such as articular cartilage and growth plate have been described to be rarely invaded by tumors and to have a tolerance against neovascularization. 2,3 Langer et al 4,5 and Kuettner et al 6 reported that some proteins extracted from cartilage had anti-angiogenic activity and inhibited tumor growth. Several proteins have been identified as anti-angiogenic factors derived from cartilage, such as cartilage-derived inhibitor, 7 transforming growth factor ␤1 (TGF␤1), 8 chondromodulin-I 9 and chondrocyte-derived inhibitor of angiogenesis and metalloproteinase activity.…”
mentioning
confidence: 99%
“…Granulation tissue formation and matrix deposition are mediated by different cell types (fibroblast, inflammatory and endothelial cells) [8,9]. MMPs and TIMPs have been implicated in the regulation of angiogenesis [10,11]. Matrix degradation allows the endothelial cells of the vessel to escape the parent venules and migrate into adjacent tissue towards the angiogenic stimulus, where they form new capillaries [12,13] …”
Section: Introductionmentioning
confidence: 99%