Dendritic cells (DCs) play a crucial role in launching protective adaptive immunity against pathogens while maintaining immune tolerance to self-antigens. However, how intracellular signaling pathways program DCs to mediate tolerogenic responses remains largely unexplored. Here we describe that p38α signaling in CD103+ mesenteric lymph node (MLN) DCs reciprocally regulates the differentiation of anti-inflammatory induced regulatory T (iTreg) cells and proinflammatory Th1 cells from naïve precursors, and promo…
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