Control of keratinization with alpha-hydroxy acids and related compounds. I. Topical treatment of ichthyotic disorders

Scott, Edward M.; Yu, Ruey J.

doi:10.1001/archderm.110.4.586

Cited by 99 publications

(38 citation statements)

References 6 publications

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“…These findings have also been histologically confirmed by Fisher et al [24]. Finally, α-hydroxy acids (αHAs) have been widely used in cosmetic products to improve skin damage caused by UV light, having been successfully shown to decrease roughness, solar keratosis, and excessive pigmentation, as well as to increase collagen levels and elastic-fibre density [25] [26] [27]. Products containing HAs generally improve exfoliation and moisturization [28].…”

Section: Discussionmentioning

confidence: 87%

Improving Skin Aging, Skin Hydration and Sensitive Skin with Four Specific Skin Care Products: Results from a Single-Centre, Observational, Prospective Study

Piccioni¹,

García-Rodrigo²,

Pellegrini³

et al. 2017

JCDSA

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In this study, we assessed the efficacy and safety of four skin care products indicated for skin hydration (Aqua Therapy  and Perfecta ) and are formulated with a specific combination of active compounds (Dermo28  ). Evaluation of sebum secretion, hydration and pH of the skin (all groups), wrinkle severity (Unica Resurfacing Therapy  ) and erythema (Comfort Therapy  ) was performed at baseline and after 4 weeks of treatment. A significant increase in hydration was recorded in subjects with dry skin receiving Aqua Therapy  for facial hydration and Perfecta  for body hydration, respectively (p < 0.001 for both). A significant decrease in the modified Fitzpatrick wrinkle scale (p = 0.006) and an increase in sebum secretion and hydration (p = 0.013 and p < 0.001, respectively) were observed in the Unica Resurfacing Therapy  group. In subjects with sensitive skin (Comfort Therapy  ), a decrease in erythema (p = 0.012), an increase in sebum secretion (p = 0.001) and hydration (p < 0.001), and a reduction in pH (p = 0.005) were detected at the end of treatment. Only one patient reported a minor adverse event. This specific combination of active ingredients was clinically effective and safe, and contributed to skin surface hydrolipidic film regeneration, improvement of wrinkle depth and reduction of redness.

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Section: Discussionmentioning

confidence: 87%

Improving Skin Aging, Skin Hydration and Sensitive Skin with Four Specific Skin Care Products: Results from a Single-Centre, Observational, Prospective Study

Piccioni¹,

García-Rodrigo²,

Pellegrini³

et al. 2017

JCDSA

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“…Alpha-hydroxy acids (AHAs) were first identified as substances with benefits in the treatment of disorders associated with abnormal keratinization [1]. Studies of the effects of topical application of AHAs to skin of adults beyond the age of 50 have shown that sustained applications cause thickening of the epidermis, compared with control skin [2,3].…”

Section: Introductionmentioning

confidence: 99%

Glycolic acid induces keratinocyte proliferation in a skin equivalent model via TRPV1 activation

Denda

Inoué

et al. 2010

Journal of Dermatological Science

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“…This study had been performed as a multicenter, randomized, placebo-controlled, double-blind, semilateral investigation, whereas numerous previous studies concerning the application of urea were not controlled against their own vehicle nor were treatment areas left untreated nor have been conducted as a blinded and randomized study [5, 6, 7]. To our knowledge there is only one other study using a placebo-controlled, double-blind approach.…”

Section: Discussionmentioning

confidence: 99%

“…It is not surprising that the lotion base has also a good effect on hyperkeratotic skin since it contains 5% of lactic acid, which is of course also contained in the ‘verum’ which additionally has incorporated 10% of urea. The positive effects of lactic acid and other related alpha-hydroxy acids in the treatment of ichthyotic disorders are well established [6]. …”

Section: Discussionmentioning

confidence: 99%

Efficacy of Urea Therapy in Children with Ichthyosis

Küster¹,

Bohnsack²,

Rippke³

et al. 1998

Dermatology

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Background: Ichthyoses are genetic disorders of keratinization which are uncomfortable due to their conspicuous scaling, itching and cosmetic problems. Especially in childhood, ichthyoses can lead to social discrimination and psychological problems. Efficient therapies are necessary which are safe and well tolerated. Objective: The aim of the study was to investigate the keratolytic and moisterurizing properties as well as the tolerance of a new urea lotion when applied to hyperkeratotic and ichthyotic skin in childhood. Methods: The study was conducted as a multicenter, randomized, placebo-controlled, double-blind, semilateral investigation. Sixty children between 1 and 16 years treated one side of the most affected extremity with Laceran 10% urea lotion for 8 weeks. On the other side the urea-free Laceran lotion base was given. On each side of the body a control area was left untreated. The investigators evaluated the global severity of ichthyotic symptoms with the help of a visual analogue scale. Results: The analysis of the global estimation of severity of ichthyosis showed improvements being stronger in the body areas treated with Laceran 10% urea lotion (from 4.8 to 2.0 points) than in the areas treated with the urea-free Laceran lotion base (from 4.8 to 2.5 points). The response rates were 65% after 4 weeks and 78% after 8 weeks for Laceran 10% urea lotion, 50% after 4 weeks and 72% after 8 weeks for the urea-free Laceran lotion base. Conclusion: It can be ascertained that Laceran 10% urea lotion has a strong positive effect on generalized ichthyotic keratinization disorders.

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Control of keratinization with alpha-hydroxy acids and related compounds. I. Topical treatment of ichthyotic disorders

Cited by 99 publications

References 6 publications

Improving Skin Aging, Skin Hydration and Sensitive Skin with Four Specific Skin Care Products: Results from a Single-Centre, Observational, Prospective Study

Improving Skin Aging, Skin Hydration and Sensitive Skin with Four Specific Skin Care Products: Results from a Single-Centre, Observational, Prospective Study

Glycolic acid induces keratinocyte proliferation in a skin equivalent model via TRPV1 activation

Efficacy of Urea Therapy in Children with Ichthyosis

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