Control of Food Intake

Geiselman, Paula J.

doi:10.1016/s0889-8529(05)70356-x

Cited by 32 publications

(5 citation statements)

References 81 publications

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“…Feeding is thus a complex motivated behavior (Geiselman, 1996) that requires the integration of hunger and satiety cues conveyed by internal signals, information relayed by the physical and chemical senses, the overall emotional state and, in humans, the conscious motivation of an individual. In contrast to a reflex, no single stimulus can be predicted to trigger this complex behavior with certainty, with each of these inputs influencing the likelihood that the coordinated effector events required for feeding will be initiated.…”

Section: Introductionmentioning

confidence: 99%

Molecular Annotation of Integrative Feeding Neural Circuits

et al. 2011

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SUMMARY The identity of higher-order neurons and circuits playing an associative role to control feeding is unknown. We injected pseudorabies virus, a retrograde tracer, into masseter muscle, salivary gland and tongue of BAC-transgenic mice expressing GFP in specific neural populations and identified several CNS regions that project multi-synaptically to the periphery. MCH and orexin neurons were identified in the lateral hypothalamus, and Nurr1 and Cnr1 in the amygdala and insular/rhinal cortices. Cholera Toxin-β tracing showed that insular Nurr1+ and Cnr1+ neurons project to the amygdala or lateral hypothalamus, respectively. Finally we show that cortical Cnr1+ neurons show increased Cnr1 mRNA and c-Fos expression after fasting, consistent with a possible role for Cnr1+ neurons in feeding. Overall, these studies define a general approach for identifying specific molecular markers for neurons in complex neural circuits. These markers now provide a means for functional studies of relevant neurons in feeding or other complex behaviors.

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Section: Introductionmentioning

confidence: 99%

Molecular Annotation of Integrative Feeding Neural Circuits

et al. 2011

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“…In addition, organisms employ requisite energy by taking food from external environment. The adjustment of feeding is related to a sophisticated system formed by external and internal circumstances (Geiselman, 1996; Suzuki et al, 2010). In T. castaneum , down‐regulated insulin/InR signalling inhibited food intake (Lin et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Functional characterisation of Fe (II) and 2OG‐dependent dioxygenase TcALKBH4 in the red flour beetle, Tribolium castaneum

Zhang

et al. 2023

Insect Molecular Biology

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Alpha‐ketoglutarate‐dependent dioxygenase ALKB homologue 4 (ALKBH4) is a member of the Fe (II) and 2‐oxoglutarate‐dependent ALKB homologue family that plays important roles in epigenetic regulation by alkyl lesions removal in mammals. However, the roles of ALKBH4 in insects are not clear. Here, TcALKBH4 was cloned and functionally characterised in Tribolium castaneum. Temporal expression revealed that TcALKBH4 was highly expressed in early embryos and early pupae. Spatial expression showed that TcALKBH4 was highly expressed in the adult testis, and followed by the ovary. RNA interference targeting TcALKBH4 at different developmental stages in T. castaneum led to apparent phenotypes including the failure of development in larvae, the reduction of food intake and the deficiency of fertility in adult. However, further dot blot analyses showed that TcALKBH4 RNAi does not seem to influence 6 mA levels in vivo. qRT‐PCR was used to further explore the underlying molecular mechanisms; the result showed that TcALKBH4 mediates the development of larvae possibly through 20E signalling pathway, and the fertility of female and male adult might be regulated by the expression of vitellogenesis and JH signalling pathway, respectively. Altogether, these findings will provide new insights into the potential function of ALKBH4 in insects.

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“…Posee una secuencia de aminoácidos homóloga en el 50% a la del glucagón. Se le ha implicado en la regulación a corto plazo de la conducta alimentaria 103 . Su inyección intracerebroventricular en ratas inhibe la ingesta alimentaria 104 .…”

Section: Glp-1 (Péptido Análogo Al Glucagon-1)unclassified

Pharmacological treatment of obesity

2009

An Sist Sanit Navar

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RESUMENLa base en la que se sustenta el tratamiento de la obesidad descansa sobre los procedimientos encaminados a desequilibrar la ecuación de balance energético a favor del consumo calórico.El tratamiento farmacológico se dirige a favorecer la reducción en la ingesta calórica o a estimular la producción calórica. Dependiendo de su mecanismo de acción los fármacos que se emplean en el tratamiento de la obesidad pueden dividirse en inhibidores del apetito, bloqueadores de la absorción/digestión de alimentos y estimuladores de la termogénesis. Entre los inhibidores del apetito, además de los fármacos de acción adrenérgica como los de tipo anfetamínico, que se encuentran proscritos por su efecto adictivo, destacan los agonistas serotoninérgicos como dexfenfluramina (retirado en 1997) y fluoxetina. La reciente comercialización de la sibutramina, un inhibidor de la recaptación de serotonina y noradrenalina con efecto inhibidor del apetito y estimulador de la termogénesis, ofrece nuevas perspectivas en este campo. Entre los fármacos inhibidores de la absorción merece mención el orlistat que inhibe la absorción de hasta el 30% de grasa ingerida sin ocasionar efectos secundarios de trascendencia. En el terreno de los fármacos termogénicos se encuentra la asociación efedrina-cafeína, y los agonistas β-3 adrenérgicos, que se encuentran aún en el campo de la investigación. Existen numerosas perspectivas futuras entre las que se figuran la leptina, análogos de GLP-1 y colecistoquinina y antagonistas de neuropéptido Y. Es necesario contar con elementos predictivos que permitan conocer el fármaco más util y los pacientes que más se van a beneficiar de los diferentes tratamientos farmacológicos.Palabras clave: Obesidad. Sibutramina. Orlistat. Agonistas β-3 adrenérgicos. GLP-1. Colecistoquinina. ABSTRACTThe foundation on which the treatment of obesity rests is made up of the procedures aimed at unbalancing the equation of energy balance in favour of calorie consumption.Pharmacological treatment is aimed at favouring a reduction of calorie intake or stimulating calorie production. Depending on their mechanism of action, the drugs that are used in the treatment of obesity can be divided into appetite inhibitors, inhibitors of food intake or blockers of fat digestion and stimulators of thermogenesis. Amongst the appetite inhibitors, besides the adrenergic agents such as those of the amphetamine type, which are forbidden because of their addictive effect, are the serotonin uptake inhibitors such as dexfenfluramine (withdrawn in 1997) and fluoxetine. The recent commercialisation of sibutramine, a serotonin and norepinephrine reuptake inhibitor with an appetite inhibiting and thermogenesis stimulating effect, offer new perspectives in this field. Amongst inhibitors, mention is deserved by orlistat that inhibits the absorption of upto 30% of ingested fat without causing secondary effects of significance. In the area of thermogenic drugs there are the ephedrine-caffeine association, and the adrenergic beta antagonists, which are still ...

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Control of Food Intake

Cited by 32 publications

References 81 publications

Molecular Annotation of Integrative Feeding Neural Circuits

Molecular Annotation of Integrative Feeding Neural Circuits

Functional characterisation of Fe (II) and 2OG‐dependent dioxygenase TcALKBH4 in the red flour beetle, Tribolium castaneum

Pharmacological treatment of obesity

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