Control of endothelial cell gene expression by flow

Malek, Adel M.; Izumo, Seigo

doi:10.1016/0021-9290(95)00099-2

Cited by 151 publications

(119 citation statements)

References 56 publications

(119 reference statements)

Supporting

Mentioning

115

Contrasting

Order By: Relevance

“…Alterations in endothelial cell behavior under different flow conditions has previously been demonstrated (Malek et al 1995). Endothelial cells are stimulated by shear, resulting in increased NOS expression (Tsao et al 1996;Ziegler et al 1998;Kader et al 2000) and SOD expression (Takeshita et al 2000).…”

Section: Shear Environmentmentioning

confidence: 89%

“…Endothelial cell function and gene expression is also altered under different shear conditions, including laminar flow and oscillatory flow (Malek et al 1995;Ando et al 1996;Boyle et al 1997;Takahashi et al 1997;Traub et al 1998;Sorop et al 2003;Uhlenbrock et al 2003). Altered endothelial cell function is important in vascular disease states, as atherosclerotic lesions tend to form in regions with low shear stress or regions of oscillatory shear (De Keulenaer et al 1998;De Nigris et al 2001;).…”

Section: Gene Expressionmentioning

confidence: 99%

“…In addition, endothelial nitric oxide synthase (NOS) can produce large amounts of O 2 .-when the enzyme becomes uncoupled from its normal substrates (Milstien et al 1999;Witteveen et al 1999;Vasquez-Vivar et al 2002;Zou et al 2002;Landmesser et al 2003 (Beckman et al 1990;Pryor et al 1995), although this has not been demonstrated experimentally. Finally, endothelial cells in vivo are exposed to shear stress, which modulates many key aspects of endothelial metabolism and function, including NO release (Griffith 2002), NOS expression (Dimmeler et al 1999;Davis et al 2004), copper/zinc superoxide dismutase expression (Dimmeler et al 1999;Woodman et al 1999), and the expression of other endothelial cell genes (Malek et al 1995 …”

Section: Introductionmentioning

confidence: 99%

“…As multiple endothelial cell mechanisms including nitric oxide release (Griffith 2002), nitric oxide synthase expression (Dimmeler et al 1999;Davis et al 2004), copper/zinc superoxide dismutase expression (Dimmeler et al 1999;Woodman et al 1999), and endothelial cell gene expression (Malek et al 1995) are shear dependant.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Mechanisms of H2O2-induced oxidative stress in endothelial cells

Coyle

Martínez

Coleman

et al. 2006

Free Radical Biology and Medicine

115

View full text Add to dashboard Buy / Rent full text

“…The endothelium of the hyperkinetic cardiovascular system of people from stratum 3 are probably exposed to high sheer stress which could lead to damage of the endothelium and subsequent atherosclerosis and sustained hypertension in their later life. 42 …”

Section: Independent Variablementioning

confidence: 99%

An epidemiological study of hypertension and its determinants in a population in transition: the THUSA study

Rooyen¹,

Kruger²,

Huisman³

et al. 2000

J Hum Hypertens

View full text Add to dashboard Buy / Rent full text

Background: Many black persons in South Africa have been subjected to urbanisation and urbanisation has led to a significant increase in diseases of lifestyle. The determinants of hypertension in a population in transition have not been well-defined and there is a pressing need for observational epidemiological studies as well as randomised-controlled trials in populations from Africa. The aim of this study was to investigate the association between blood pressure and factors known to contribute to hypertension. Methods: The study sample consisted mainly of Setswana speaking people, divided into different levels (strata) of urbanisation, namely stratum 1 (rural) to stratum 5 (urbanised). A total of 1821 black subjects, which included 1040 woman, were recruited and randomly selected from 37 sites from the four geographical quarters of the North West Province of South Africa. The following questionnaires were used: demographic, anthropometric, quantitative food frequency, physical activity and scales to measure psychosocial variables. Biochemical analysis (standardised methods) were done on the serum and plasma of the subjects and the

show abstract

Control of endothelial cell gene expression by flow

Cited by 151 publications

References 56 publications

Mechanisms of H2O2-induced oxidative stress in endothelial cells

An epidemiological study of hypertension and its determinants in a population in transition: the THUSA study

Contact Info

Product

Resources

About