Current Opinion in Hematology volume 17, issue 3, P230-236 2010 DOI: 10.1097/moh.0b013e328338664b View full text
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Dietmar Vestweber, Andre Broermann, Dörte Schulte

Abstract: Endothelial cell contacts are regulated by a complex interplay between various receptors and signaling mediators that control the plasticity of the cytoskeleton and the function of junctional adhesion molecules. Knowing and understanding the essential players of this network will allow development of agents that could prevent breakdown of the vascular permeability barrier in shock or that could block leukocyte extravasation and thereby antagonize inflammation.