Control of blood pressure, heart rate and haematocrit during high‐dose intravenous paraoxon exposure in mini pigs

Comparison of the Ability of Pyridinium Aldoximes to Reactivate Human Red Blood Cell Acetylcholinesterases Inhibited by ethyl- and methyl-paraoxon

“…The inhibition of cholinesterases causes accumulation of acetylcholine, which drives an initial sympathomimetic response due to stimulation of nicotinergic receptors in the adrenal medulla followed by a longer-lasting parasympathomimetic response due to stimulation of muscarinic receptors. Both responses can and must be controlled by appropriate medications [9]. In addition, organophosphates and organophosphonates cause an acetylcholine overflow at neuromuscular synapses with ensuing depolarizing block, requiring artificial ventilation.…”

Preparing a rat brain tissue samples for acetylcholinesterase activity measurement: The MM method

“…2-PAM, which is most commonly used oxime in the treatment of OP poisonings, has a relatively low level of transport through the BBB. [15][16][17] Respiratory failure has been identified in numerous studies as the leading cause of death in OP poisoning. [18][19][20] Houze et al 21 have shown that respiratory failure is most likely the result of central respiratory depression, rather than peripheral bronchoconstriction, bronchorrhoea and There was no significant difference between mean values of AChE activity in rat brain between C and CW group (Student t-test: t = 0.52, p = 0.655), but there was significant difference between Pox and PoxW group (t = 5.00, p = 0.044) (Figure 7).…”

Poisoning with organophosphorus compounds

“…>> 30 µg kg −1 BW −1 min −1 ). Although we did not measure catecholamine levels we speculate that the observed phenomena are ‘phaeochromocytoma‐like’ 3 …”