Contributions to Survival Made by Body Cells of Genetically Differentiated Strains of Mice Following X-Irradiations

Volitional activity of inbred and hybrid mice as influenced by x-radiation

“…Therefore, even when particular organs are involved in the response, there may be an additional factor (the absence of any unexposed cells for compensating effects) operating in whole-body-irradiated animals. Stadler and Gowen (1957) found that this hypothesis fits their data when considering survival abilities of totally and partially irradiated strains of mice.…”

“…Inbred mice were from strain S and strain BALB/Gw (henceforth referred to as Ba). These strains have been found to be least susceptible and most susceptible to X-radiation, respectively, In regard to factors such as lethality (Stadler and Gowen, 1957) and body weight changes (Grahn, 1954) among the ten inbred strains in the laboratory. The median lethal dose whole-body-X-irra diation (250 pkv, 30 ma, 0.25 Ou 1.0 Al filter) for 15 days was estimated by Stadler and Gowen (1957) for 46-day-old mice as 537 r for strain S and 438 r for strain Ba.…”

“…Since at this time only 24 wheels, and in some instances fewer mice, were available, only one body third could be tested in an experi ment. Because other work had indicated that the head region is less likely to show a radiation effect, (Glaus, 1958;Stadler and Gowen, 1957) the decisions to concentrate on this area first and to assign a larger number of animals to this group than to the other thirds were made. Post-treatment measurements were taken for a period of 12 days in the manner already described.…”

Effects of partial-body X-radiation on learning of inbred strains of mice

“…The inbred mice had been separated into distinct strains through 30+ generations of brcrther-by-sister matings* Both strains are homozygous albino but differ in many physiological characteristics including total body weight, weight of organs, number of leucocytes, metabolism of fat, storage of glycogen, and resistance to Salmonella typhimurium (Gowen, 1950;Gowen and Stadler, 1956;Stadler and Gowen, 1957 Having made one error, a mouse could make another by leaving the incorrect alley by one full body length and then either returning to the incorrect alley or entering the central alley* A limit of 5 minutes per trial ws set. Any mouse remaining $ minutes was shoved to the goal.…”

Volitional activity of inbred and hybrid mice as influenced by x-radiation

“…Inbred mice were from strain S and strain BALB/Gw (henceforth referred to as Ba). These strains have been found to be least susceptible and most susceptible to X-radiation, respectively, In regard to factors such as lethality (Stadler and Gowen, 1957) and body weight changes (Grahn, 1954) (Figure 1). 2964 revolutions of the wheel equal a distance of one mile.…”