Contributions of regional adipose tissue depots to plasma lipoprotein concentrations in overweight men and women: Possible protective effects of thigh fat

Terry, Richard; Stefanick, Marcia L.; Haskell, William L.; Wood, Peter D.

doi:10.1016/0026-0495(91)90093-c

Cited by 150 publications

(84 citation statements)

References 30 publications

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“…[25][26][27][28][29] In humans, larger leg fat mass by dual-energy X-ray absorptiometry or larger thigh fat area by computed tomography has been found to be associated with favourable levels of cardiovascular risk factors including lipids and glucose levels in a few studies now. [30][31][32][33][34][35] In line with the latter mechanism, the strongest negative associations of the hip circumference would be expected to be observed with triglycerides, which we found in the present study, followed by slightly weaker but relevant associations with glucose levels. After adjustment for BMI, BP showed no strong association with the fat distribution measures.…”

Section: Discussionsupporting

confidence: 86%

Independent and opposite associations of waist and hip circumferences with diabetes, hypertension and dyslipidemia: the AusDiab Study

et al. 2004

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OBJECTIVE: Fat distribution as measured by waist-to-hip ratio has been shown to be an important independent predictor of glucose intolerance. Few studies, however, have considered the contributions of the waist and hip circumferences independently. The aim of this study was to investigate the independent associations of waist and hip circumference with diabetes in a large population-based study, and to investigate whether they also apply to other major components of the metabolic syndrome (hypertension and dyslipidemia). In addition, as previous studies were performed in older persons, we investigated whether these associations were present across adult age groups. METHODS: Weight, height, waist and hip circumferences were measured in 11 247 participants of the nationally representative Australian Diabetes, Obesity and Lifestyle (AusDiab) Study. HDL-cholesterol, triglycerides, fasting and 2-h postload glucose were determined, and diastolic and systolic blood pressure was measured. After exclusion of persons already known to have diabetes, hypertension or dyslipidemia, logistic and linear regression were used to study cross-sectional associations of anthropometric variables with newly diagnosed diabetes, hypertension and dyslipidemia, and with continuous metabolic measures, all separately for men (n ¼ 3818) and women (n ¼ 4582). Analyses were repeated in the same population stratified for age. RESULTS: After adjustment for age, body mass index and waist, a larger hip circumference was associated with a lower prevalence of undiagnosed diabetes (odds ratio (OR) per one s.d. increase in hip circumference 0.55 (95% CI 0.41-0.73) in men and 0.42 (0.27-0.65) in women) and undiagnosed dyslipidemia (OR 0.58 (0.50-0.67) in men and 0.37 (0.30-0.45) in women). Associations with undiagnosed hypertension were weaker (OR 0.80 (0.69-0.93) in men and 0.88 (0.70-1.11) in women). As expected, larger waist circumference was associated with higher prevalence of these conditions. Similar associations were found using continuous metabolic variables as outcomes in linear regression analyses. Height partly explained the negative associations with hip circumference. When these analyses were performed stratified for age, associations became weaker or disappeared in the oldest age groups (age Z75 y in particular), except for HDL-cholesterol. CONCLUSION: We found independent and opposite associations of waist and hip circumference with diabetes, dyslipidemia and less strongly with hypertension in a large population-based survey. These results emphasize that waist and hip circumference are important predictors for the metabolic syndrome and should both be considered in epidemiological studies. The associations were consistent in all age groups, except in age Z75 y. Further research should be aimed at verifying hypotheses explaining the 'protective' effect of larger hips.

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Section: Discussionsupporting

confidence: 86%

Independent and opposite associations of waist and hip circumferences with diabetes, hypertension and dyslipidemia: the AusDiab Study

et al. 2004

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“…Diante da perspectiva de que o excesso de gordura na região central do corpo está associado aos dois principais fatores de risco biológicos predisponentes ao aparecimento e desenvolvimento das doenças cardiovasculares 29 , a mobilização preferencial da gordura localizada nessa região mediante a prática de exercícios aeróbicos deverá se caracterizar como mais um importante motivo para a inclusão da atividade física nos programas de prevenção e reabilitação das coronariopatias.…”

Section: Discussionunclassified

Distribuição de gordura corporal, pressão arterial e níveis de lipídios-lipoproteínas plasmáticas

Guedes¹,

Guedes²

1998

Arq. Bras. Cardiol.

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Purpose -To study associations between FAT distribution and blood pressure levels and concentrations of lipids and lipoproteins, irrespective of body fat content and physical activity.Methods -A sample of 62 subjects of both genders aging 20-45 years-old Estudos recentes sugerem que a variação da distribuição anatômica da gordura corporal é importante indicador morfológico relacionado com complicações endócrinas e metabólicas predisponentes ao aparecimento e desenvolvimento de doenças cardiovasculares 1-3 . Indivíduos com

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“…Gluteofemoral fat, as measured by thigh circumference, hip circumference or leg adipose tissue mass, is independently associated with lower total-and low-density lipoprotein-cholesterol, and total-and very-low-density lipoprotein-TG levels, and higher highdensity lipoprotein-cholesterol levels. [12][13][14][15][16][17] Atherosclerotic Gluteofemoral fat and metabolic health KN Manolopoulos et al protection is not only conveyed by an improved lipid profile, but also through direct effects on vascular health: increased gluteofemoral fat mass is associated with lower aortic calcification and arterial stiffness, [18][19][20] as well as with a decreased progression of aortic calcification. 21 Leg adipose tissue mass change after a 14-week intervention study with diet and exercise is inversely associated with diastolic blood pressure, low-density lipoprotein-cholesterol levels and the number of coronary heart disease-risk factors (that is, blood pressure, fasting plasma glucose levels and levels of individual lipid fractions).…”

Section: Body Fat Distribution and Riskmentioning

confidence: 99%

Gluteofemoral body fat as a determinant of metabolic health

2010

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Body fat distribution is an important metabolic and cardiovascular risk factor, because the proportion of abdominal to gluteofemoral body fat correlates with obesity-associated diseases and mortality. Here, we review the evidence and possible mechanisms that support a specific protective role of gluteofemoral body fat. Population studies show that an increased gluteofemoral fat mass is independently associated with a protective lipid and glucose profile, as well as a decrease in cardiovascular and metabolic risk. Studies of adipose tissue physiology in vitro and in vivo confirm distinct properties of the gluteofemoral fat depot with regards to lipolysis and fatty acid uptake: in day-to-day metabolism it appears to be more passive than the abdominal depot and it exerts its protective properties by long-term fatty acid storage. Further, a beneficial adipokine profile is associated with gluteofemoral fat. Leptin and adiponectin levels are positively associated with gluteofemoral fat while the level of inflammatory cytokines is negatively associated. Finally, loss of gluteofemoral fat, as observed in Cushing's syndrome and lipodystrophy is associated with an increased metabolic and cardiovascular risk. This underlines gluteofemoral fat's role as a determinant of health by the long-term entrapment of excess fatty acids, thus protecting from the adverse effects associated with ectopic fat deposition.

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Contributions of regional adipose tissue depots to plasma lipoprotein concentrations in overweight men and women: Possible protective effects of thigh fat

Cited by 150 publications

References 30 publications

Independent and opposite associations of waist and hip circumferences with diabetes, hypertension and dyslipidemia: the AusDiab Study

Independent and opposite associations of waist and hip circumferences with diabetes, hypertension and dyslipidemia: the AusDiab Study

Distribuição de gordura corporal, pressão arterial e níveis de lipídios-lipoproteínas plasmáticas

Gluteofemoral body fat as a determinant of metabolic health

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