Contribution of Transferrin and Ceruloplasmin Neurotransmission and Oxidant/Antioxidant Status to the Effects of Everolimus: A Case Series

Yui, Kunio; Imataka, George; Sasaki, Hidetada; Kawasaki, Yohei; Yoshihara, Shigemi

doi:10.7759/cureus.6920

Cited by 2 publications

(3 citation statements)

References 20 publications

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“…Cp expression in myelinating glial cells is crucial to prevent oxidative stress and neurodegeneration in the central and peripheral nervous systems [ 61 ]. Lower plasma Cp levels may contribute to ASD pathophysiology in young individuals [ 62 , 63 , 64 ]. AA is a known regulator of signal transduction proteins and acts as a precursor of potent signaling molecules [ 63 , 64 , 65 ].…”

Section: Copper Signalingmentioning

confidence: 99%

“…Lower plasma Cp levels may contribute to ASD pathophysiology in young individuals [ 62 , 63 , 64 ]. AA is a known regulator of signal transduction proteins and acts as a precursor of potent signaling molecules [ 63 , 64 , 65 ]. Importantly, these findings indicate that the signaling mediator Cp levels are downregulated via a competitive association between plasma omega-3 PUFAs and omega-6 PUFAs, such as AA [ 63 , 65 ].…”

Section: Copper Signalingmentioning

confidence: 99%

“…AA is a known regulator of signal transduction proteins and acts as a precursor of potent signaling molecules [ 63 , 64 , 65 ]. Importantly, these findings indicate that the signaling mediator Cp levels are downregulated via a competitive association between plasma omega-3 PUFAs and omega-6 PUFAs, such as AA [ 63 , 65 ]. Specifically, lower plasma Cp levels due to lower plasma AA levels may impair various signaling activities.…”

Section: Copper Signalingmentioning

confidence: 99%

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Lipid-Based Molecules on Signaling Pathways in Autism Spectrum Disorder

Yui

Imataka

Yoshihara

2022

IJMS

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The signaling pathways associated with lipid metabolism contribute to the pathophysiology of autism spectrum disorder (ASD) and provide insights for devising new therapeutic strategies. Prostaglandin E2 is a membrane-derived lipid molecule that contributes to developing ASD associated with canonical Wnt signaling. Cyclooxygenase-2 plays a key role in neuroinflammation and is implicated in the pathogenesis of neurodevelopmental diseases, such as ASD. The endocannabinoid system maintains a balance between inflammatory and redox status and synaptic plasticity and is a potential target for ASD pathophysiology. Redox signaling refers to specific and usually reversible oxidation–reduction reactions, some of which are also involved in pathways accounting for the abnormal behavior observed in ASD. Redox signaling and redox status-sensitive transcription factors contribute to the pathophysiology of ASD. Cannabinoids regulate the redox balance by altering the levels and activity of antioxidant molecules via ROS-producing NADPH oxidase (NOX) and ROS-scavenging superoxide dismutase enzymes. These signaling cascades integrate a broad range of neurodevelopmental processes that may be involved in the pathophysiology of ASD. Based on these pathways, we highlight putative targets that may be used for devising novel therapeutic interventions for ASD.

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Section: Copper Signalingmentioning

confidence: 99%

Section: Copper Signalingmentioning

confidence: 99%

Section: Copper Signalingmentioning

confidence: 99%

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Lipid-Based Molecules on Signaling Pathways in Autism Spectrum Disorder

Yui

Imataka

Yoshihara

2022

IJMS

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Subependymal Giant Cell Astrocytomas in Tuberous Sclerosis Complex—Current Views on Their Pathogenesis and Management

Gao

Zabielska

Jiao

et al. 2023

JCM

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Introduction, Tuberous sclerosis complex (TSC) is an autosomal-dominant disorder caused by mutations inactivating TSC1 or TSC2 genes and characterized by the presence of tumors involving many organs, including the brain, heart, kidneys, and skin. Subependymal giant cell astrocytoma (SEGA) is a slow-growing brain tumor almost exclusively associated with TSC. State of the Art: Despite the fact that SEGAs are benign, they require well-considered decisions regarding the timing and modality of pharmacological or surgical treatment. In TSC children and adolescents, SEGA is the major cause of mortality and morbidity. Clinical Implications: Until recently, surgical resection has been the standard therapy for SEGAs but the discovery of the role of the mTOR pathway and the introduction of mTOR inhibitors to clinical practice changed the therapeutic landscape of these tumors. In the current paper, we discuss the pros and cons of mTOR inhibitors and surgical approaches in SEGA treatment. Future Directions: In 2021, the International Tuberous Sclerosis Complex Consensus Group proposed a new integrative strategy for SEGA management. In the following review, we discuss the proposed recommendations and report the results of the literature search for the latest treatment directions.

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Contribution of Transferrin and Ceruloplasmin Neurotransmission and Oxidant/Antioxidant Status to the Effects of Everolimus: A Case Series

Cited by 2 publications

References 20 publications

Lipid-Based Molecules on Signaling Pathways in Autism Spectrum Disorder

Lipid-Based Molecules on Signaling Pathways in Autism Spectrum Disorder

Subependymal Giant Cell Astrocytomas in Tuberous Sclerosis Complex—Current Views on Their Pathogenesis and Management

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