2019
DOI: 10.1155/2019/6367402
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Abstract: The pleiotropic effects of statins have been evaluated to assess their potential benefit in the treatment of various inflammatory and immune-mediated diseases including periodontitis. Herein, the adjunctive use of statins in periodontal therapy in vitro, in vivo, and in clinical trials was reviewed. Statins act through several pathways to modulate inflammation, immune response, bone metabolism, and bacterial clearance. They control periodontal inflammation through inhibition of proinflammatory cytokines and pr… Show more

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Cited by 54 publications
(54 citation statements)
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References 153 publications
(174 reference statements)
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“…Although the primary mode of action for statins is to lower LDL-C level, increasing lines of evidence support the notion that statins also have lipid-independent pleiotropic effects including anti-inflammatory functions 41,42 . It was also proposed that the effects of statins on periodontal therapy did not depend on its lipid-lowering effects 43 . Indeed, our results revealed that RSV showed a direct role in preventing the differentiation of osteoclasts.…”
Section: Discussionmentioning
confidence: 99%
“…Although the primary mode of action for statins is to lower LDL-C level, increasing lines of evidence support the notion that statins also have lipid-independent pleiotropic effects including anti-inflammatory functions 41,42 . It was also proposed that the effects of statins on periodontal therapy did not depend on its lipid-lowering effects 43 . Indeed, our results revealed that RSV showed a direct role in preventing the differentiation of osteoclasts.…”
Section: Discussionmentioning
confidence: 99%
“…It was a study in which only 14 cases of statin users were analyzed. Statins have been extensively studied in the context of bone regeneration in periodontal disease, but soft tissue healing remains relatively less studied [ 27 ]. Further statin studies should be considered as a potential adjunct therapeutic strategy with a positive effect on the healing of hard and soft periodontal tissues.…”
Section: Discussionmentioning
confidence: 99%
“…In summary, choosing the optimal dose of statins, based on the drug delivery method and carrier used, can increase the positive effect of statins on periodontal treatment results. Besides, combining statins with growth factors or other drugs in an efficient carrier system may be beneficial in promoting periodontal regeneration [ 27 ]. Further research is needed focusing on the possible effect of statins in masking symptoms of fungal infection.…”
Section: Discussionmentioning
confidence: 99%
“…In addition, non-surgical treatment alone is insufficient for adjuvant therapy ( Abdul Rahman et al, 2019 ; Harmouche et al, 2019 ). Therefore, use of local delivery of active drugs has been utilized as an effective strategy to address the inflammation and promote tissue repair ( Morand et al, 2017 ; Batool et al, 2018 ; Petit et al, 2019 ). By means of the injectable chitosan hydrogels with modulable physico-chemical properties, CS-based delivery system can be employed as reliable vehicle to release the encapsulated active drugs (e.g., statins, doxycycline, antibiotics, and antiseptics) at the disease site within periodontal pockets ( Özdoğan et al, 2018 ).…”
Section: Cs-based Hydrogelsmentioning
confidence: 99%