Contribution of late fetal deaths to US perinatal mortality rates, 1995–1998

Barfield, Wanda D.; Tomashek, Kay M.; Flowers, Lisa; Iyasu, Solomon

doi:10.1053/sper.2002.29850

Cited by 27 publications

(13 citation statements)

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“…The two extremes of abnormal fetal growth are restricted growth and excessive growth; at both extremes, the fetus must adapt to survive (1). Small‐for‐gestation‐age (SGA) 1 infants are a public health problem because they are at higher risk for morbidity and rehospitalization during the first year of life (2, 3). In addition, long‐term complications of reduced fetal growth have been identified in the past 10 years.…”

Section: Introductionmentioning

confidence: 99%

Mitochondrial DNA Depletion in Small‐ and Large‐for‐Gestational‐Age Newborns

Gemma

Sookoian

Alvariñas

et al. 2006

Obesity

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Research Methods and Procedures:Eighty-eight pregnant women and their infants were included in a cross-sectional study. According to the offspring birthweight, normalized by sex and gestational age, there were 57 newborns with appropriate weight for gestational age (AGA) and 31 with abnormal weight for gestational age: 17 small for gestational age (SGA) and 14 large for gestational age (LGA). mtDNA quantification using nuclear DNA as a reference was measured by a real-time quantitative polymerase chain reaction method. Results: The mothers' pregestational BMI was associated with the weight of their offspring: SGA infants had lean mothers (BMI, 21.4 Ϯ 0.7), and LGA infants had overweight mothers (BMI, 26.7 Ϯ 1.4) in comparison with AGA infants (BMI, 23.0 Ϯ 0.7) (p Ͻ 0.003). Newborn leptin levels were associated with birthweight after adjustment for sex and gestational age (SGA, 7.0 Ϯ 1.1 ng/mL; AGA, 15.2 Ϯ 1.6 ng/mL; and LGA, 25.6 Ϯ 4.1 ng/mL) (p Ͻ 0.002). Conversely, mtDNA/nuclear DNA ratio was significantly lower in both extremes of abnormal fetal growth, SGA (18 Ϯ 6) and LGA (9 Ϯ 2), at birth in comparison to AGA-weight infants (28 Ϯ 4) (p Ͻ 0.03). Discussion: Our findings show that mtDNA content is decreased in newborns with abnormal weight in comparison with AGA infants. On the basis of a cumulative body of evidence, we speculate that mtDNA depletion is one of the putative links between abnormal fetal growth and metabolic and cardiovascular complications in later life.

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Section: Introductionmentioning

confidence: 99%

Mitochondrial DNA Depletion in Small‐ and Large‐for‐Gestational‐Age Newborns

Gemma

Sookoian

Alvariñas

et al. 2006

Obesity

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“…Studies documenting greater underreporting and misclassification of deaths at the extremes of birth weight and gestational age prompted states to focus on changes in reporting of extremely low birth weight deliveries of live-born infants and early fetal losses [5][6][7][8]. All states examined historic changes in definitions of fetal deaths based on birth weight and/or gestational age, along with changes in the completeness of reporting of fetal and infant deaths.…”

Section: Assessment Data Reporting: Definition and Methodsmentioning

confidence: 99%

“…Incomplete reporting of live births less than 500 grams (g) and changes in state reporting rules for fetal deaths, resulting in more fetal deaths or fetal deaths being recorded as live births, may mask improvements in neonatal mortality despite clear reductions in birth-weight-specific mortality [4]. Timeliness of data availability affects the speed with which programs can detect changes in IMR and respond.Studies documenting greater underreporting and misclassification of deaths at the extremes of birth weight and gestational age prompted states to focus on changes in reporting of extremely low birth weight deliveries of live-born infants and early fetal losses [5][6][7][8]. All states examined historic changes in definitions of fetal deaths based on birth weight and/or gestational age, along with changes in the completeness of reporting of fetal and infant deaths.…”

mentioning

confidence: 99%

Developing a Standard Approach to Examine Infant Mortality: Findings from the State Infant Mortality Collaborative (SIMC)

Stampfel

Kroelinger

Dudgeon

et al. 2012

Matern Child Health J

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States can improve pregnancy outcomes by using a standard approach to assess infant mortality. The State Infant Mortality Collaborative (SIMC) developed a series of analyses to describe infant mortality in states, identify contributing factors to infant death, and develop the evidence base for implementing new or modifying existing programs and policies addressing infant mortality. The SIMC was conducted between 2004 and 2006 among five states: Delaware, Hawaii, Louisiana, Missouri, and North Carolina. States used analytic strategies in an iterative process to investigate contributors to infant mortality. Analyses were conducted within three domains: data reporting (quality, reporting, definitional criteria, and timeliness), cause and timing of infant death (classification of cause and fetal, neonatal, and postneonatal timing), and maturity and weight at birth/maturity and birth weight-specific mortality. All states identified the SIMC analyses as useful for examining infant mortality trends. In each of the three domains, SIMC results were used © Springer Science+Business Media New York 2012 Correspondence to: Caroline Stampfel, cstampfel@amchp.org. Disclaimer: The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. All partners contributed to the initial design, eligibility criteria, five-state selection process, and/or ongoing scientific and technical assistance. We examine the benefits of this standard approach for assessing infant mortality by: (1) describing the SIMC process, including a comparison of five state analyses on direct contributors to infant mortality; (2) defining the strategies identified for each analysis; and (3) summarizing application of analytic findings to modify existing policies or programs. HHS Public Access DescriptionBetween 2004 and 2006, the SIMC was implemented to aid states in investigation of infant mortality through facilitated meetings with subject matter experts, review and recommendation of appropriate data sources, development of standard approaches for analyses of infant mortality causes and contributors, and interpretation of findings both consistent with the literature and useful for each participating state for programmatic and policy-making decisions.Using available infant mortality data for all 50 states and the District of Columbia, eligibility for application to the collaborative was determined using information reflecting high or increasing burden of infant mortality. The following information was used to score state Author Manuscript Author ManuscriptAuthor Manuscript Author Manuscript eligibility: (1) three types of trend analyses, (2) the states' average IMR, and (3) states' raceadjusted IMR. Of 22 states which met the minimum scoring, the top 13 were determined to be eligible for the project; eight states applied and five were selected to participate, including Delaware, Hawaii, Louisiana, Missouri, and North Carolina. Each selected s...

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“…[2][3][4] Factors that might have contributed to the decline in cigarette use include (1) a 90% increase in the retail price of cigarettes during December 1997-May 2003, 5 (2) increases in school-based efforts to prevent tobacco use, and (3) increases in the proportion of young persons who have been exposed through the mass media to smoking-prevention campaigns funded by states or the American Legacy Foundation. 6 Factors that might have slowed the rate of decline in cigarette use among young persons include (1) tobacco industry expenditures on tobacco advertising and promotion, which increased from $5.7 billion in 1997 to $11.2 billion in 2001 7 ; (2) reductions in Master Settlement Agreement funds used for tobacco-use prevention; and (3) the frequency with which smoking was depicted in films. 8 The findings in this report are subject to at least two limitations.…”

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confidence: 99%

Racial/Ethnic Trends in Fetal Mortality—United States, 1990-2000

2004

JAMA

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Contribution of late fetal deaths to US perinatal mortality rates, 1995–1998

Cited by 27 publications

References 13 publications

Mitochondrial DNA Depletion in Small‐ and Large‐for‐Gestational‐Age Newborns

Mitochondrial DNA Depletion in Small‐ and Large‐for‐Gestational‐Age Newborns

Developing a Standard Approach to Examine Infant Mortality: Findings from the State Infant Mortality Collaborative (SIMC)

Racial/Ethnic Trends in Fetal Mortality—United States, 1990-2000

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