Contribution of Intermediate Progenitor Cells to Cortical Histogenesis

Promotion of proliferation in the developing cerebral cortex by EphA4 forward signaling

“…Although questions regarding heterogeneity of progenitor cells in the VZ (Gal et al, 2006; Malatesta et al, 2003) and the roles of intermediate progenitor cells within the SVZ (Mizutani et al, 2007; Noctor et al, 2007) exist, our results simply demonstrate that EphA4 signaling influences cortical proliferation. For example, when EphA4-mediated signaling is reduced, affected cells divide less, and when signaling is elevated, cells are more mitotically active.…”

Promotion of proliferation in the developing cerebral cortex by EphA4 forward signaling

“…Although questions regarding heterogeneity of progenitor cells in the VZ (Gal et al, 2006; Malatesta et al, 2003) and the roles of intermediate progenitor cells within the SVZ (Mizutani et al, 2007; Noctor et al, 2007) exist, our results simply demonstrate that EphA4 signaling influences cortical proliferation. For example, when EphA4-mediated signaling is reduced, affected cells divide less, and when signaling is elevated, cells are more mitotically active.…”

Aerobic exercise in adolescence results in an increase of neuronal and non-neuronal cells and in mTOR overexpression in the cerebral cortex of rats

“…Although neurogenesis in the hippocampal formation is largely accepted, and studies have shown that chronic exercise increases the volume of the motor cortex (Kleim et al, 2002;Ding et al, 2006), new neuronal formation in the postnatal cerebral cortex is still very controversial. For example, Noctor et al (2007) observed that cortical neurogenesis ends after the first postnatal week, whereas Bandeira et al (2009), using the same cell count method used in our study (isotropic fractionator), found an exponential increase of neurons in the cerebral cortex of rats between P15 and P25. Moreover, the authors noted that the number of cortical neurons doubles from P15 to adulthood (P70) (Bandeira et al, 2009).…”

A matrigel-free method to generate matured human cerebral organoids using 3D-Printed microwell arrays

“…Lumens supply Sox2+ cells that differentiate and migrate to support neurogenesis, ventricle expansion, and cortical development [ 68 , [71] , [72] , [73] ]. Thus, lumen properties (size, thickness, and number) may be critical to the organoids' subsequent cortical layer development [ 74 ].…”

Promotion of proliferation in the developing cerebral cortex by EphA4 forward signaling

“…Although questions regarding heterogeneity of progenitor cells in the VZ (Gal et al, 2006; Malatesta et al, 2003) and the roles of intermediate progenitor cells within the SVZ (Mizutani et al, 2007; Noctor et al, 2007) exist, our results simply demonstrate that EphA4 signaling influences cortical proliferation. For example, when EphA4-mediated signaling is reduced, affected cells divide less, and when signaling is elevated, cells are more mitotically active.…”

Aerobic exercise in adolescence results in an increase of neuronal and non-neuronal cells and in mTOR overexpression in the cerebral cortex of rats

“…Although neurogenesis in the hippocampal formation is largely accepted, and studies have shown that chronic exercise increases the volume of the motor cortex (Kleim et al, 2002;Ding et al, 2006), new neuronal formation in the postnatal cerebral cortex is still very controversial. For example, Noctor et al (2007) observed that cortical neurogenesis ends after the first postnatal week, whereas Bandeira et al (2009), using the same cell count method used in our study (isotropic fractionator), found an exponential increase of neurons in the cerebral cortex of rats between P15 and P25. Moreover, the authors noted that the number of cortical neurons doubles from P15 to adulthood (P70) (Bandeira et al, 2009).…”

A matrigel-free method to generate matured human cerebral organoids using 3D-Printed microwell arrays

“…Lumens supply Sox2+ cells that differentiate and migrate to support neurogenesis, ventricle expansion, and cortical development [ 68 , [71] , [72] , [73] ]. Thus, lumen properties (size, thickness, and number) may be critical to the organoids' subsequent cortical layer development [ 74 ].…”

Promotion of proliferation in the developing cerebral cortex by EphA4 forward signaling

“…Although questions regarding heterogeneity of progenitor cells in the VZ (Gal et al, 2006; Malatesta et al, 2003) and the roles of intermediate progenitor cells within the SVZ (Mizutani et al, 2007; Noctor et al, 2007) exist, our results simply demonstrate that EphA4 signaling influences cortical proliferation. For example, when EphA4-mediated signaling is reduced, affected cells divide less, and when signaling is elevated, cells are more mitotically active.…”

Aerobic exercise in adolescence results in an increase of neuronal and non-neuronal cells and in mTOR overexpression in the cerebral cortex of rats

“…Although neurogenesis in the hippocampal formation is largely accepted, and studies have shown that chronic exercise increases the volume of the motor cortex (Kleim et al, 2002;Ding et al, 2006), new neuronal formation in the postnatal cerebral cortex is still very controversial. For example, Noctor et al (2007) observed that cortical neurogenesis ends after the first postnatal week, whereas Bandeira et al (2009), using the same cell count method used in our study (isotropic fractionator), found an exponential increase of neurons in the cerebral cortex of rats between P15 and P25. Moreover, the authors noted that the number of cortical neurons doubles from P15 to adulthood (P70) (Bandeira et al, 2009).…”

A matrigel-free method to generate matured human cerebral organoids using 3D-Printed microwell arrays

“…Lumens supply Sox2+ cells that differentiate and migrate to support neurogenesis, ventricle expansion, and cortical development [ 68 , [71] , [72] , [73] ]. Thus, lumen properties (size, thickness, and number) may be critical to the organoids' subsequent cortical layer development [ 74 ].…”