Contribution of diffusion tensor imaging to delineation of gliomas and glioblastomas

Tropine, Andrei; Vučurević, Goran; Delani, P.; Boor, Stephan; Hopf, Nikolai J.; Bohl, J.; Stoeter, P.

doi:10.1002/jmri.20217

Cited by 120 publications

(84 citation statements)

References 19 publications

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“…Fractional anisotropy values were significantly lower in all tumors than in adjacent and contralateral white matter. However, as others have also reported, 5,9,20,23,24 this index did not help in distinguishing between tumor grades. For example, Wieshmann et al 24 reported decreased FA values in pathological brain lesions that included low-and high-grade tumors, traumatic brain injury, perinatal infarcts and hypoxia, and cortical dysplasia.…”

Section: Discussionmentioning

confidence: 59%

“…In a DT imaging study of peritumoral tissue in high-grade gliomas and metastatic lesions, Lu and coauthors 10 reported that the tumors can be distinguished based on mean diffusivity but not on FA values in the peritumoral tissue. Tropine et al 23 studied tumor tissue, white matter adjacent to the tumor, and white matter in the contralateral hemisphere in patients with tumors of different grades and types. These authors found that FA and mean diffusivity values are notably different between tumors in all tumor groups and contralateral white matter.…”

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confidence: 99%

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Characterization of abnormal diffusion properties of supratentorial brain tumors: a preliminary diffusion tensor imaging study

Yuan¹,

Holland²,

Jones

et al. 2008

PED

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Object Diffusion tensor (DT) imaging was used in children with supratentorial tumors to evaluate the anisotropic diffusion properties between different tumor grades and between tumors and adjacent and contralateral white matter. Methods In this retrospective review, the authors review the cases of 16 children (age range 1–18 years) who presented to their institution with supratentorial tumors and were treated between 2004 and 2007. Eleven patients had low-grade and 5 had high-grade tumors. Fractional anisotropy (FA), mean diffusivity, and axial (λ∥) and radial (λ⊥) eigenvalues within selected regions were studied. Mitotic index, necrosis, and vascularity of the tumors were compared with DT imaging parameters. Results The mean diffusivity was significantly higher in low-grade than in high-grade tumors (p = 0.04); the 2 tumor grades also significantly differed for both λ∥ (p < 0.05) and λ⊥ (p < 0.05). Mean diffusivity values in low-grade tumors were significantly higher than in adjacent normal-appearing white matter (NAWM; p = 0.0004) and contralateral NAWM (p = 0.0001). In both low- and high-grade tumors, the FA was significantly lower than in NAWM (p < 0.0001 and p < 0.03, respectively) and contralateral NAWM (p < 0.0001 and p < 0.003, respectively). Tumor cellularity highly correlated with mean diffusivity and λ∥and λ⊥. Conclusions Diffusion tensor imaging is a useful tool in the evaluation of supratentorial tumors in children. The mean diffusivity appears to be a significant marker in differentiating tumors grades. Findings related to λ∥ and λ⊥ within tumor groups and between tumors and NAWM may be an indirect manifestation of the combined effects of axonal injury, demyelination, and tumor mass within the cranial compartment.

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Section: Discussionmentioning

confidence: 59%

mentioning

confidence: 99%

Characterization of abnormal diffusion properties of supratentorial brain tumors: a preliminary diffusion tensor imaging study

Yuan¹,

Holland²,

Jones

et al. 2008

PED

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“…Our results are consistent with Castillo (35), who found that the ADC values helped to distinguish high-grade glioma from normal tissue but could not be used to separate highgrade glioma from surrounding edema. Other studies (28,(34)(35)(36)(37)(38)(39)(40) have reported that high-grade tumors have significantly lower ADC values than low-grade and benign tumors and that peritumoral ADC is significantly higher in low-grade than in high-grade astrocytomas. In cases where the minimum ADC was considered, it was lower in high-grade gliomas than in the low-grade gliomas and appeared to be correlated well with tumor cellularity (26).…”

Section: Discussionmentioning

confidence: 98%

Perfusion, diffusion and spectroscopy values in newly diagnosed cerebral gliomas

et al. 2006

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Purpose To evaluate perfusion, diffusion, and spectroscopy values in enhancing and non-enhancing lesions for patients with newly diagnosed gliomas of different grades. Materials and Methods Sixty-seven patients with newly diagnosed glioma were entered into the study 20 grade II, 26 grade III and 21 grade IV. MR data were acquired at 1.5T and included diffusion weighted images (59/67 patients), dynamic perfusion weighted images (30/67 patients) and 3D H-1 MR spectroscopy (64/67 patients). Enhancing and non-enhancing lesions were delineated by a neuroradiologist and applied to maps of relative cerebral blood volume (rCBV), apparent diffusion coefficient (ADC), relative anisotropy (RA) and metabolite intensities. Results The median rCBV within enhancing regions of grade IV gliomas was significantly elevated relative to enhancing regions in grade III gliomas and normal brain. ADC was elevated relative to normal brain, but was not significantly different between grades or between enhancing and non-enhancing regions. The RA was higher in the non-enhancing region of grade IV gliomas relative to grade II and grade III. Levels of lactate plus lipid were significantly elevated in grade IV relative to grade II and grade III gliomas. Both enhancing and non-enhancing regions in grade IV gliomas showed significant correlations between CBV, ADC and choline levels. Conclusion The data were consistent with grade IV gliomas having higher membrane turnover, increased cell density and increased vascularity within enhancing lesions. Analysis of the correlations among parameters within grade IV gliomas suggested that high vascularity (high rCBV) was correlated with increased cellularity (low ADC) and increased membrane turnover (high choline) in these lesions. The non-enhancing region of grades II and III gliomas had MR parameters consistent with increased cellularity and/or membrane turnover.

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“…Also several studies have shown no significant difference for mean FA between low-and high-grade gliomas. [8][9][10] Secondary to these conflicting results, mean FA values may not be useful for the preoperative grading of cerebral gliomas.…”

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confidence: 99%

Diffusion Tensor MR Imaging of Cerebral Gliomas: Evaluating Fractional Anisotropy Characteristics

White¹,

Zhang²,

Yu³

et al. 2010

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE: FA correlation to glioma tumor grade has been mixed if not disappointing. There are several potential underlying fundamental issues that have contributed to these results. In an attempt to overcome these past shortfalls, we evaluated characteristics of FA of the solid tissue components of gliomas, including whether high-grade gliomas have a greater variation of FA than low-grade gliomas.

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Contribution of diffusion tensor imaging to delineation of gliomas and glioblastomas

Cited by 120 publications

References 19 publications

Characterization of abnormal diffusion properties of supratentorial brain tumors: a preliminary diffusion tensor imaging study

Characterization of abnormal diffusion properties of supratentorial brain tumors: a preliminary diffusion tensor imaging study

Perfusion, diffusion and spectroscopy values in newly diagnosed cerebral gliomas

Diffusion Tensor MR Imaging of Cerebral Gliomas: Evaluating Fractional Anisotropy Characteristics

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