Contribution for the phytochemical studies of Ageratum fastigiatum

Abstract

Organic extracts from leaves plus branches plus inflorescences of Ageratum fastigiatum (Gardner) R. M. King & H. Rob., Asteraceae, were fractionated through classic chromatography. The steroids stigmasterol, chondrillasterol and campesterol were isolated from hexane extract. The triterpenes lupeol, taraxasterol, α-amyrin, β-amyrin, pseudotaraxasterol, lupeol acetate and α-amyrin acetate were isolated from ethyl acetate extract. Steroids and triterpenes were identified by GC-MS. The coumarin ayapin was isolated from ethanol extract and identified by NMR. Essential oils of the fresh leaves and fresh inflorescences were obtained by hydrodistillation and analyzed for GC-MS. The main components in both essential oils were α-pinene, limonene and germacrene D.

Bioactivities of the ethanol extract from Ageratum fastigiatum branches: antioxidant, antinociceptive and anti-inflammatory

“…In this context, although antinociceptive and anti-inflammatory activities of A. fastigiatum had been previously described by our research group, this is the first report to establish a full scientific understanding for medicinal use of the branches, an important part of this plant widely used as extract by population after maceration (Gonçalves et al 2011). Therefore, in the present study, the antioxidant, antinociceptive and anti-inflammatory properties of the ethanol extract from A. fastigiatum branches using appropriate experimental animal models were investigated.…”

“…The branches of this species are indicated in traditional medicine as cicatrizing, anti-inflammatory, analgesic and antimicrobial (Del-Vechio-Vieira et al 2008). Phytochemical studies have identified diterpenes, triterpenes, steroids, coumarins and derivatives (Gonçalves et al 2011, Del-Vechio et al 2007, Bohlmann et al 1981, 1983. The main compounds found in the essential oil were α-pinene, limonene, germacrene D, α-humulene and β-cedrene (Gonçalves et al 2011, Del-VechioVieira et al 2009a.…”

“…Phytochemical studies have identified diterpenes, triterpenes, steroids, coumarins and derivatives (Gonçalves et al 2011, Del-Vechio et al 2007, Bohlmann et al 1981, 1983. The main compounds found in the essential oil were α-pinene, limonene, germacrene D, α-humulene and β-cedrene (Gonçalves et al 2011, Del-VechioVieira et al 2009a. In addition, the essential oil and the ethanol extract from A. fastigiatum leaves revealed antinociceptive, anti-inflammatory and antimicrobial activities (Del-Vechio et al 2007, Del-Vechio-Vieira et al 2009a.…”

Chemical constituents of Pseudobrickellia brasiliensis leaves(Spreng.) R.M. King & H. Rob. (Asteraceae)

“…The calculated RRIs were compared with those observed for a series of terpene standards, as described in the literature (Gonçalves et al, 2011). The terpene standards used were previously isolated from extracts of various plants and identified by 1 H-NMR and 13 C-NMR (presented good degree of purity) and are deposited at the Núcleo de Pesquisa em Produtos Naturais e Sintéticos, da Faculdade de Ciências Farmacêuticas de Ribeirão Preto -USP (SP, Brazil).…”

Metabolômica como ferramenta em taxonomia: O modelo em Arnica. Metabolomics in plant taxonomy: The Arnica model

“…In Brazil Ageratum fastigiatum is also known as "matapasto" or "enxota" and aqueous extracts are used to treat pain and inflammations (GONÇALVES et al, 2011). Substances that were isolated from this species include triterpenes, diterpenes, coumarin, eudesmane derivatives, labdane derivatives and steroids (see Table 8).…”