Contrasting pediatric and adult cerebral malaria

Plasmodium falciparum Histidine-Rich Protein II Compromises Brain Endothelial Barriers and May Promote Cerebral Malaria Pathogenesis

“…Cerebral malaria is accompanied by upregulation of cytoadherence molecules on the vascular endothelium ( 37 – 39 ). We assessed the surface expression of several relevant adhesion receptors on human brain microvascular endothelial cells after treatment with HRPII.…”

Plasmodium falciparum Histidine-Rich Protein II Compromises Brain Endothelial Barriers and May Promote Cerebral Malaria Pathogenesis

“…Cerebral malaria is accompanied by upregulation of cytoadherence molecules on the vascular endothelium ( 37 – 39 ). We assessed the surface expression of several relevant adhesion receptors on human brain microvascular endothelial cells after treatment with HRPII.…”

Cerebral Malaria in Adults: A Retrospective Descriptive Analysis of 80 Cases in a Tertiary Hospital in The Gambia, 2020–2023

“…Convulsion at the time of presentation was documented in 30% of the CM patients which is similar to that found in India [ 9 ]. Studies have also found a decrease in the incidence of convulsion with increasing age [ 25 ] and convulsions were higher in children with CM as compared to adults with CM [ 24 ]. Even though convulsion is a more common symptom in children with CM, a significant proportion of adults may still present with it.…”

Plasma angiopoietin-2 is associated with age-related deficits in cognitive sub-scales in Ugandan children following severe malaria

“…There is also evidence that Angpt-2-integrin interactions can lead to astrocyte and pericyte apoptosis in experimental models of hyperglycaemia [ 9 , 10 ]. Both astrocytes and pericytes are involved in active regulation of blood–brain-barrier integrity and loss of either cell type in conjunction with endothelial activation could contribute to blood–brain-barrier dysfunction and neuro-inflammation in malaria (reviewed in [ 32 ]). Additional studies are needed to determine whether Angpt-2-integrin interactions contribute to endothelial activation and blood–brain-barrier dysfunction in severe malaria, and whether maturational changes in the blood–brain-barrier explain the Angpt-2 age-related effects observed in this study.…”

Plasmodium falciparum Histidine-Rich Protein II Compromises Brain Endothelial Barriers and May Promote Cerebral Malaria Pathogenesis

“…Cerebral malaria is accompanied by upregulation of cytoadherence molecules on the vascular endothelium ( 37 – 39 ). We assessed the surface expression of several relevant adhesion receptors on human brain microvascular endothelial cells after treatment with HRPII.…”

Cerebral Malaria in Adults: A Retrospective Descriptive Analysis of 80 Cases in a Tertiary Hospital in The Gambia, 2020–2023

“…Convulsion at the time of presentation was documented in 30% of the CM patients which is similar to that found in India [ 9 ]. Studies have also found a decrease in the incidence of convulsion with increasing age [ 25 ] and convulsions were higher in children with CM as compared to adults with CM [ 24 ]. Even though convulsion is a more common symptom in children with CM, a significant proportion of adults may still present with it.…”

Plasma angiopoietin-2 is associated with age-related deficits in cognitive sub-scales in Ugandan children following severe malaria

“…There is also evidence that Angpt-2-integrin interactions can lead to astrocyte and pericyte apoptosis in experimental models of hyperglycaemia [ 9 , 10 ]. Both astrocytes and pericytes are involved in active regulation of blood–brain-barrier integrity and loss of either cell type in conjunction with endothelial activation could contribute to blood–brain-barrier dysfunction and neuro-inflammation in malaria (reviewed in [ 32 ]). Additional studies are needed to determine whether Angpt-2-integrin interactions contribute to endothelial activation and blood–brain-barrier dysfunction in severe malaria, and whether maturational changes in the blood–brain-barrier explain the Angpt-2 age-related effects observed in this study.…”

Plasmodium falciparum Histidine-Rich Protein II Compromises Brain Endothelial Barriers and May Promote Cerebral Malaria Pathogenesis

“…Cerebral malaria is accompanied by upregulation of cytoadherence molecules on the vascular endothelium ( 37 – 39 ). We assessed the surface expression of several relevant adhesion receptors on human brain microvascular endothelial cells after treatment with HRPII.…”

Cerebral Malaria in Adults: A Retrospective Descriptive Analysis of 80 Cases in a Tertiary Hospital in The Gambia, 2020–2023

“…Convulsion at the time of presentation was documented in 30% of the CM patients which is similar to that found in India [ 9 ]. Studies have also found a decrease in the incidence of convulsion with increasing age [ 25 ] and convulsions were higher in children with CM as compared to adults with CM [ 24 ]. Even though convulsion is a more common symptom in children with CM, a significant proportion of adults may still present with it.…”

Plasma angiopoietin-2 is associated with age-related deficits in cognitive sub-scales in Ugandan children following severe malaria

“…There is also evidence that Angpt-2-integrin interactions can lead to astrocyte and pericyte apoptosis in experimental models of hyperglycaemia [ 9 , 10 ]. Both astrocytes and pericytes are involved in active regulation of blood–brain-barrier integrity and loss of either cell type in conjunction with endothelial activation could contribute to blood–brain-barrier dysfunction and neuro-inflammation in malaria (reviewed in [ 32 ]). Additional studies are needed to determine whether Angpt-2-integrin interactions contribute to endothelial activation and blood–brain-barrier dysfunction in severe malaria, and whether maturational changes in the blood–brain-barrier explain the Angpt-2 age-related effects observed in this study.…”