“…In literature there are various meta-analyses comparing LOCM and IOCM in terms of nephrotoxicity. Some studies conclude that there are no significant differences in the incidence of CI-AKI between LOCM and IOCM (Biondi-Zoccai et al, 2014;Eng et al, 2016;Heinrich et al, 2009;Pandya et al, 2017;Reed et al, 2009), but other studies report greater safety of the IOCM compared with LOCM (Laskey et al, 2009;Xiong et al, 2018). Most of the observational studies on "all-comers" patients did not find a higher profile of kidney safety for IOCM compared with LOCM (Azzalini et al, 2018b;Briguori et al, 2005).…”