Contralateral Risk-Reducing Mastectomy: Review of Risk Factors and Risk-Reducing Strategies

Basu, Naren; Barr, Lester; Ross, Gary; Evans, D. Gareth

doi:10.1155/2015/901046

Cited by 19 publications

(24 citation statements)

References 59 publications

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“…Overall uptake of contralateral riskreducing mastectomy was 14 % over a 25-year periodhowever the rates are increasing rapidly with the passage of time-10 % (1985-2001) -22 % (2001-2010). SEER (Surveillance, Epidemiology and End Results Program) data indicate a 150 % increase in the rates of contralateral risk-reducing mastectomy that includes mutation carriers and non-BRCA1/2 high family risk patients [7]. Rhiem et al [26] found that the risk of contralateral breast cancer for BRCA1/2 negative families is low and similar to that in women with sporadic breast cancer, confirming our finding that contralateral breast cancer risk is dependant on mutation status and age of onset of first breast cancer.…”

Section: Discussionmentioning

confidence: 99%

“…During the extended observation period in our study, there have been inevitable changes in practice-one of the main being a global decrease in the incidence of contralateral breast cancer [7,27]. We have accounted for some of these potential confounding factors, particularly the omission of oestrogen receptor status.…”

Section: Discussionmentioning

confidence: 99%

“…Several factors impact on contralateral breast cancer risk [1,[4][5][6][7]. BRCA1 and BRCA2 mutation carriers develop breast cancer at an earlier age than in non-mutation carriers [1].…”

Section: Introductionmentioning

confidence: 99%

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Risk of contralateral breast cancer in BRCA1 and BRCA2 mutation carriers: a 30-year semi-prospective analysis

et al. 2015

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BRCA1 and BRCA2 mutation carriers have an increased risk of contralateral breast cancer after primary breast cancer. Risk reduction strategies are discussed after assessment of risk factors for developing contralateral breast cancer. We assessed potential risk factors that could be of use in clinical practice, including the novel use of single nucleotide polymorphisms (SNP) testing. 506 BRCA1 and 505 BRCA2 mutation carriers with a diagnosis of breast cancer were observed for up to 30 years. The risk of a contralateral breast cancer is approximately 2-3% per year, remaining constant for at least 20 years. This was similar in both BRCA1 and BRCA2 carriers. Initial breast cancer before age 40-years was a significant risk factor, which was more pronounced in BRCA1 patients. The effect of risk-reducing oophorectomy on contralateral breast cancer risk may be overestimated because of bias. No significant association was found between overall breast cancer risk SNP score and contralateral breast cancer development. Young mutation carriers, particularly those with BRCA1 mutations, who develop breast cancer have a significantly higher risk of developing contralateral breast cancer, remaining constant for over 20 years. Contralateral risk-reducing mastectomy should be considered in this group, in particular as there is a survival benefit. Caution is advised when counselling women considering risk-reducing oophorectomy as, after accounting for statistical bias, the associated risk reduction was found to be non-significant, and potentially smaller than has been previously reported. SNP testing did not add any further discriminatory information when assessing contralateral breast cancer risk.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Risk of contralateral breast cancer in BRCA1 and BRCA2 mutation carriers: a 30-year semi-prospective analysis

et al. 2015

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“…We reviewed risk factors for CBC 15 and designed a questionnaire to assess some of these factors. In particular, we wanted to gauge how surgeons assess requests for CRRM, what factors they considered important when recommending this procedure and issues on funding.…”

Section: Methodsmentioning

confidence: 99%

Attitudes to contralateral risk reducing mastectomy among breast and plastic surgeons in England

Basu

Littlechild²,

Barr³

et al. 2016

annals

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“…Basu et al, summarized 15 the main factors increasing the risk of developing CBC which were listed as follows:…”

Section: The Perceived Risk Vs the Real Risk Of Cbcmentioning

confidence: 99%

Contralateral risk reducing mastectomy in patients with sporadic breast cancer. Benefits and hazards

Boccardo

Gentilini

2016

European Journal of Surgical Oncology (EJSO)

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Contralateral Risk-Reducing Mastectomy: Review of Risk Factors and Risk-Reducing Strategies

Cited by 19 publications

References 59 publications

Risk of contralateral breast cancer in BRCA1 and BRCA2 mutation carriers: a 30-year semi-prospective analysis

Risk of contralateral breast cancer in BRCA1 and BRCA2 mutation carriers: a 30-year semi-prospective analysis

Attitudes to contralateral risk reducing mastectomy among breast and plastic surgeons in England

Contralateral risk reducing mastectomy in patients with sporadic breast cancer. Benefits and hazards

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