Contractile activity of vasotocin, oxytocin, and vasopressin on mammalian prostate

Bodanszky, Miklos; Sharaf, Hammouda Hassan; Roy, Jitendra Nath; Said, Sami I.

doi:10.1016/0014-2999(92)90376-f

Cited by 50 publications

(32 citation statements)

References 8 publications

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“…41 Some of the other peptides having effects in human prostate include oxytocin and vasopressin. 42 Although purinoceptor mechanisms have been investigated briefly in human prostate tissue, 43 their role in human prostatic contractility is yet to be determined. In rats and guinea-pigs, post-junctional P2 and prejunctional adenosine receptors modulate contractility to varying degrees at different frequencies in different species.…”

Section: Animal Prostate Models Of Human Prostate Contractilitymentioning

confidence: 99%

“…23 Thus, cultured cell evidence is quite consistent with the effects of cholinergic agonists in human prostatic tissue and indicates the potential complexity of signalling in the human prostatic stroma. Both oxytocin and vasopressin 42,45 have also been shown to elicit contractions of human prostatic tissues but, as yet, there are no equivalent human cultured prostatic stromal cell data.…”

Section: Cultured Cell Models Of Human Prostate Contractilitymentioning

confidence: 99%

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Current models of human prostate contractility

Haynes

Ventura

2005

Clin Exp Pharma Physio

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SUMMARY1. The human prostate is a compact gland contributing to seminal fluid. With increasing age, most humans will develop benign prostatic hyperplasia, a condition of prostatic enlargement and contractility that leads to occlusion of the urethra. Over many years, investigators have used a variety of animal and cell culture models to elucidate some of the contractile and proliferative mechanisms that may be associated with the development of this condition.2. This review briefly assesses the current state of knowledge of the mechanisms underlying human prostatic contractility and compares it with that of animal and cell culture models. It is not intended as a comprehensive methodological review, nor is it intended to indicate our preferences for either model. Our aim is to correlate findings from animal and cell culture models with the current understanding of human prostate contractility.3. We hope that the present review will increase awareness of the suitability of the current models in developing our understanding of benign prostatic hyperplasia.

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Section: Animal Prostate Models Of Human Prostate Contractilitymentioning

confidence: 99%

Section: Cultured Cell Models Of Human Prostate Contractilitymentioning

confidence: 99%

Current models of human prostate contractility

Haynes

Ventura

2005

Clin Exp Pharma Physio

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“…However, evidence also suggests that systemic OT controls muscular contractility in the prostate gland and epididymis, thereby facilitating ejaculation [2]. One mechanism of action may be a direct effect on the smooth musculature; OT stimulates prostatic contractions in a dose-dependent manner in vitro and increases muscular tone in the rat, dog, and guinea pig [5,6]. There are very few data on functional OT receptors in eutherian male accessory glands.…”

Section: Introductionmentioning

confidence: 95%

Mesotocin Receptor Gene and Protein Expression in the Prostate Gland, but Not Testis, of the Tammar Wallaby, Macropus eugenii1

Parry

Bathgate

1998

Biology of Reproduction

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Evidence suggests that systemic oxytocin (OT) causes contractions of the prostate gland during ejaculation in eutherians, although functional OT receptors in this tissue have not been identified. Male marsupials secrete mesotocin (MT) from the pituitary and have relatively large, muscular prostate glands, so we examined MT receptors (MTRs) in the reproductive tract of the male tammar wallaby at the mRNA and protein level. We first obtained a partial (588 base pair) sequence of the tammar MTR cDNA that showed high homology to eutherian OT receptors (74-77%) and low homology to vasopressin receptors (38-52%). Analysis by reverse transcription-polymerase chain reaction demonstrated MTR mRNA in the adult, juvenile, and pouch young prostate and epididymis, but not testis. MTR transcripts were observed in the smooth muscle layers surrounding the urethral lumen and in the fibromuscular capsule. There was a single high-affinity 125I-D(CH2)5[Tyr(Me)2, Tyr4, Orn8, Tyr-NH29]-vasotocin (125I-OTA) binding site in the adult prostate. Competitive binding assays revealed identical ligand-binding profiles to the myometrium MTR (OTA > OT = MT > arginine vasopressin [AVP] antagonist > AVP). A lower-affinity 125I-OTA-binding site was present in the testis, with ligand-binding profiles indicating binding to vasopressin receptors. MTR concentrations in the prostate were 8-fold lower than concentrations in the myometrium. Our data demonstrate the presence of an MTR gene and functional receptor protein in the prostate gland, but not the testis, of the tammar. Localization of MTRs to the smooth muscle fibers in the capsule and surrounding the urethral lumen suggests a contractile function for MT during ejaculation.

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“…This function is hormonally regulated and many local biochemical mechanisms are involved. The paracrine role of oxytocin in the modulation of prostatic function has been recently elucidated (Bodanszky et al, 1992;Nicholson 1996); indeed, oxytocin is produced in the prostate under androgen regulation, and it has been shown that it increases the growth of epithelial tissue, muscular tone and contractile activity, being, in turn, involved also in the pathogenesis of benign prostatic hyperplasia (Frayne and Nicholson 1998;Nicholson and Jenkin, 1995). In contrast, the presence and the role of the atrial natriuretic factor (ANF), another peptide with endocrine/paracrine functions in many districts, has not been sufficiently investigated in the male genital tract.…”

mentioning

confidence: 99%

Presence of atrial natriuretic factor in normal and hyperplastic human prostate and its relationship with oxytocin localisation

Farina-Lipari¹,

Lipari²,

Bellafiore³

et al. 2009

Eur J Histochem

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In this work, we showed the presence of atrial natriuretic factor (ANF) in human prostate and compared its localisation in normal and hyperplastic conditions. ANF was localised in epithelial and stromal cells, being increased in hyperplasia, mainly in the stromal component. Moreover, we compared ANF and oxytocin positivity in the same glands, focusing on the possible relationship between the paracrine effects of these two hormones.

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Contractile activity of vasotocin, oxytocin, and vasopressin on mammalian prostate

Cited by 50 publications

References 8 publications

Current models of human prostate contractility

Current models of human prostate contractility

Mesotocin Receptor Gene and Protein Expression in the Prostate Gland, but Not Testis, of the Tammar Wallaby, Macropus eugenii1

Presence of atrial natriuretic factor in normal and hyperplastic human prostate and its relationship with oxytocin localisation

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