Contraceptive potential of synthetic peptides of zona pellucida protein (ZPA)

Hasegawa, Akiko; Hamada, Yukari; Shigeta, Minoru; Koyama, Koji

doi:10.1016/s0165-0378(01)00084-5

Cited by 29 publications

(20 citation statements)

References 16 publications

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“…A variety of strategies are being employed to overcome lack of efficacy, including: production of antibodies directly in the relevant area of the genital tract [51], use of B-and T-cell epitopes as carrier molecules [47,49], examination of novel adjuvants and immunopotentiators [52,53], use of passive immunization [54], humanized and anti-idiotypic antibodies [10,22,23,55,56], construction of peptide mimetics [57], use of multiple epitopes or antigens [58][59][60][61] and use of bacterial or viral vectors [35,62].…”

Section: Optimal Therapymentioning

confidence: 99%

Current advances in antifertility vaccines for fertility control and noncontraceptive applications

Ferro¹

2002

Expert Review of Vaccines

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The search for effective antifertility vaccines has been actively pursued for decades in clinical applications as contraceptives or in the treatment of hormone-dependent conditions. More recently, innovations have seen immunocontraception being employed successfully in veterinary and farming applications, as well as in population control of a number of different wildlife species. Although the basic principle behind these vaccines is the same, design considerations and criteria for commercialization are very different. This review will examine current advances in this field and evaluate the future scope of antifertility vaccines.

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Section: Optimal Therapymentioning

confidence: 99%

Current advances in antifertility vaccines for fertility control and noncontraceptive applications

Ferro¹

2002

Expert Review of Vaccines

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“…Most of the current effort on oocyte vaccines involves isolating those epitopes which are capable of activating B lymphocytes in the absence of a pathogenic T lymphocyte response [56,[58][59][60][61][62][63][64][65][66][67][68]. An immunodominant B cell epitope, the amino acids GPLTLELQI, is shared between pig, bonnet monkey and human ZPB.…”

Section: Zona Pellucidamentioning

confidence: 99%

“…This sequence is recognised by sera from both rabbits and baboons which have been immunised using a crude preparation of pig ZP antigens [58]. Other epitope mapping studies have delineated the sequence DAPDTDWCDSIP from bonnet monkey ZPB [66] and the sequence LDPEKLTL present in human and rabbit ZPA [68] as potential candidates for a zona pellucida-based vaccine. Marmoset vaccination studies suggest, however, that the use of more than one ZP epitope may be necessary in order to achieve protection, but so far it has not proved possible to identify a combination of ZP epitopes which are able to prevent pregnancy in the absence of pathological changes in the ovaries [67].…”

Section: Zona Pellucidamentioning

confidence: 99%

The development of contraceptive vaccines

Delves

2002

Expert Opinion on Investigational Drugs

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The use of vaccination as a means of controlling fertility was established during the last decade with the publication of a successful Phase II trial demonstrating the efficacy of this approach to family planning. However, only this one Phase II trial has been completed despite a plethora of hormonal and gamete antigens that have been proposed as candidate vaccines. Improvements in the design and formulation of contraceptive vaccines are underway and will be a necessary prelude to further clinical trials. AbstractThe use of vaccination as a means of controlling fertility was established during the last decade with the publication of a successful phase II trial demonstrating the efficacy of this approach to family planning. However, only this one phase II trial has been completed despite a plethora of hormonal and gamete antigens that have been proposed as candidate vaccines. Improvements in the design and formulation of contraceptive vaccines are underway and will be a necessary prelude to further clinical trials.

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“…[5][6][7][8][9] Different approaches were used to develop a vaccine that could avoid cellular responses without impairing humoral responses. [10][11][12][13][14] Most recently, we demonstrated that mouse ZP3 (mZP3) DNA and protein coadministration enhanced the contraception without abnormal follicular development, which is correlated with high antibody (Ab) titers. 15,16 Here, we try to use granulocyte-macrophage colonystimulating factor (GM-CSF) to further enhance the humoral immune responses induced by mZP3 DNA and protein coadministration.…”

Section: Introductionmentioning

confidence: 99%

Granulocyte—Macrophage Colony-Stimulating Factor Enhances the Humoral Immune Responses of Mouse Zona Pellucida 3 Vaccine Strategy Based on DNA and Protein Coadministration in BALB/c Mice

Kadir

et al. 2013

Reprod. Sci.

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We recently demonstrated that co-administration of mouse zona pellucida 3 (mZP3) DNA and protein vaccine enhanced the contraception of mice by increasing humoral immune responses. In this study, we try to use granulocyte-macrophage colonystimulating factor (GM-CSF) to further improve the humoral immune responses induced by mZP3 DNA and protein co-administration. BALB/c mice were intranasally pre-injected with GM-CSF 4 days before co-administration. Compared to DNA and protein coadministration without GM-CSF, the combination of GM-CSF and coadministration significantly enhances humoral immune responses, especially the level of secretory immunoglobulin A (sIgA) in vaginal washes. The enhanced antibody responses are correlated with the upregulated level of interleukin 4 (IL-4) and enhanced maturation of dendritic cells (DCs). Thus, GM-CSF is a potential candidate adjuvant to be used for the development of a safe and effective contraceptive vaccine.

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Contraceptive potential of synthetic peptides of zona pellucida protein (ZPA)

Cited by 29 publications

References 16 publications

Current advances in antifertility vaccines for fertility control and noncontraceptive applications

Current advances in antifertility vaccines for fertility control and noncontraceptive applications

The development of contraceptive vaccines

Granulocyte—Macrophage Colony-Stimulating Factor Enhances the Humoral Immune Responses of Mouse Zona Pellucida 3 Vaccine Strategy Based on DNA and Protein Coadministration in BALB/c Mice

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