Continuous separation of lipid particles from erythrocytes by means of laminar flow and acoustic standing wave forces

Petersson, Filip; Nilsson, Andréas; Holm, Cecilia; Jönsson, Henrik; Laurell, Thomas

doi:10.1039/b405748c

Cited by 328 publications

(276 citation statements)

References 9 publications

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“…Planar USW systems may employ resonators that are larger than a wavelength and contain multiple pressure nodal planes [12,13], but for microfluidic scale devices, a resonant cavity with an axial dimension that is lower than the operating wavelength may be employed [14][15][16]. Such sub-wavelength resonators typically rely for their operation on precise positioning of the pressure node, to which particles will migrate.…”

Section: Introductionmentioning

confidence: 99%

Modelling for the robust design of layered resonators for ultrasonic particle manipulation

2008

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a b s t r a c t Several approaches have been described for the manipulation of particles within an ultrasonic field. Of those based on standing waves, devices in which the critical dimension of the resonant chamber is less than a wavelength are particularly well suited to microfluidic, or ''lab on a chip" applications. These might include pre-processing or fractionation of samples prior to analysis, formation of monolayers for cell interaction studies, or the enhancement of biosensor detection capability. The small size of microfluidic resonators typically places tight tolerances on the positioning of the acoustic node, and such systems are required to have high transduction efficiencies, for reasons of power availability and temperature stability. Further, the expense of many microfabrication methods precludes an iterative experimental approach to their development. Hence, the ability to design sub-wavelength resonators that are efficient, robust and have the appropriate acoustic energy distribution is extremely important. This paper discusses one-dimensional modelling used in the design of ultrasonic resonators for particle manipulation and gives example of their uses to predict and explain resonator behaviour. Particular difficulties in designing quarter wave systems are highlighted, and modelling is used to explain observed trends and predict performance of such resonators, including their performance with different coupling layer materials.

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Section: Introductionmentioning

confidence: 99%

Modelling for the robust design of layered resonators for ultrasonic particle manipulation

2008

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“…In traditional planar resonators 9 the transducer is usually placed under the channel, with corresponding primary radiation forces out of the plane of the substrate. The in-plane designs of Peterson et al 14,15 , along with devices actuated by surface acoustic waves 10,16 , coupling wedges 17 or flexural waves 18 have enabled the acoustic excitation to be placed some distance from the channel, allowing easier integration with other technologies.…”

Section: Introductionmentioning

confidence: 99%

Acoustofluidics 23: acoustic manipulation combined with other force fields

Glynne‐Jones

Hill

2013

Lab Chip

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In this, the final paper of the Acoustofluidics series of tutorial articles, we discuss applications in which acoustic radiation forces are used in conjunction with competing or complementary forcefields. This may be in order to enable manipulation operations that would not be easily performed by either force-field alone, or may be used to effect separation based on the different physical principals underlying competing fields. Examples are given of a number of different applications in which acoustic forces are combined with gravitational fields, hydrodynamic forces, electric fields (including dielectrophoresis), magnetic forces and optical forces.

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“…Planar USW systems may employ resonators that are larger than a wavelength and contain multiple pressure nodal planes [19], but for microfluidic scale devices, a resonant cavity with a thickness in the direction of sound propagation that is lower than the operating wavelength is typically employed [2,20]. Such sub-wavelength resonators generally rely for their operation on precise positioning of the pressure node, to which particles will migrate.…”

Section: Introductionmentioning

confidence: 99%

“…Modulation of drive frequencies is described by Manneburg et al [26], where both high (1kHz) frequency modulation is used to average the force profile from several similar acoustic modes, and also low (0.5Hz) frequency modulation to achieve particle transport. Mode switching is presented here in the context of a conventional planar resonator, such as that shown in Figure 1, but should be equally applicable to switching between appropriate modes in a laterally excited resonant chamber such as those described by Petersson et al [5,20,25].…”

Section: Introductionmentioning

confidence: 99%

Mode-switching: A new technique for electronically varying the agglomeration position in an acoustic particle manipulator

et al. 2010

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Acoustic radiation forces offer a means of manipulating particles within a fluid. Much interest in recent years has focussed on the use of radiation forces in microfluidic (or "lab on a chip") devices. Such devices are well matched to the use of ultrasonic standing waves in which the resonant dimensions of the chamber are smaller than the ultrasonic wavelength in use. However, such devices have typically been limited to moving particles to one or two predetermined planes, whose positions are determined by acoustic pressure nodes/antinodes set up in the ultrasonic standing wave. In most cases devices have been designed to move particles to either the centre or (more recently) the side of a flow channel using ultrasonic frequencies that produce a half or quarter wavelength over the channel respectively.It is demonstrated here that by rapidly switching back and forth between half and quarter wavelength frequencies -mode-switching -a new agglomeration position is established that permits beads to be brought to any arbitrary point between the half and quarter wave nodes. This new agglomeration position is effectively a position of stable equilibrium. This has many potential applications, particularly in cell sorting and manipulation. It should also enable precise control of agglomeration position to be maintained regardless of manufacturing tolerances, temperature variations, fluid medium characteristics and particle concentration.

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Continuous separation of lipid particles from erythrocytes by means of laminar flow and acoustic standing wave forces

Abstract: Improved continuous acoustic particle separation (separation efficiency close to 100%) and separation of erythrocytes (red blood cells) from lipid microemboli in whole blood is reported.

Cited by 328 publications

References 9 publications

Modelling for the robust design of layered resonators for ultrasonic particle manipulation

Modelling for the robust design of layered resonators for ultrasonic particle manipulation

Acoustofluidics 23: acoustic manipulation combined with other force fields

Mode-switching: A new technique for electronically varying the agglomeration position in an acoustic particle manipulator

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