Continuous O2-Evolving MnFe2O4 Nanoparticle-Anchored Mesoporous Silica Nanoparticles for Efficient Photodynamic Therapy in Hypoxic Cancer

Kim, Jong-Hoon; Cho, Hye Rim; Jeon, Hyejin; Kim, Dokyoon; Song, Changyeong; Lee, Jun Young; Choi, Seung Hong; Hyeon, Taeghwan

doi:10.1021/jacs.7b05559

Cited by 613 publications

(371 citation statements)

References 33 publications

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“…Photodynamic therapy (PDT) has been proven to be a potential therapeutic strategy for cancers1 via the reaction between photosensitizers and oxygen (O 2 ) under laser to generate cytotoxic reactive oxygen species (ROS) for killing cancer cells 2, 3, 4, 5, 6. Compared to traditional cancer therapy strategies, such as surgery, chemotherapy, and radiotherapy, PDT emerges as a promising treatment method with less invasiveness, fewer side effects, and higher selectivity and efficacy 2, 4, 7, 8, 9.…”

Section: Introductionmentioning

confidence: 99%

“…Compared to traditional cancer therapy strategies, such as surgery, chemotherapy, and radiotherapy, PDT emerges as a promising treatment method with less invasiveness, fewer side effects, and higher selectivity and efficacy 2, 4, 7, 8, 9. Because the PDT process is dependent on O 2 concentration, tumor hypoxia originating from the rapid tumor growth and abnormal tumor vessels3, 10, 11 limits the efficacy of PDT and promotes therapeutic resistance and cancer progression 12, 13…”

Section: Introductionmentioning

confidence: 99%

“…However, the spontaneous exchange of O 2 and carbon dioxide (CO 2 ) results insufficient O 2 delivery 15. Hyperbaric oxygen therapy, as another method to relieve cancer hypoxia, is limited by its intrinsic side effects, such as hyperoxic seizures and barotraumas 2, 3. Recently, nanomaterials have been synthesized to deliver or generate O 2 molecules, including perfluorocarbon, CaO 2 , MnO 2 , and hydrogen peroxide (H 2 O 2 ) or catalase loaded nanoparticles 2, 3, 15, 16, 17, 18, 19, 20.…”

Section: Introductionmentioning

confidence: 99%

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Oxygen‐Evolving Mesoporous Organosilica Coated Prussian Blue Nanoplatform for Highly Efficient Photodynamic Therapy of Tumors

et al. 2018

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Oxygen (O2) plays a critical role during photodynamic therapy (PDT), however, hypoxia is quite common in most solid tumors, which limits the PDT efficacy and promotes the tumor aggression. Here, a safe and multifunctional oxygen‐evolving nanoplatform is costructured to overcome this problem. It is composed of a prussian blue (PB) core and chlorin e6 (Ce6) anchored periodic mesoporous organosilica (PMO) shell (denoted as PB@PMO‐Ce6). In the highly integrated nanoplatform, the PB with catalase‐like activity can catalyze hydrogen peroxide to generate O2, and the Ce6 transform the O2 to generate more reactive oxygen species (ROS) upon laser irradiation for PDT. This PB@PMO‐Ce6 nanoplatform presents well‐defined core–shell structure, uniform diameter (105 ± 12 nm), and high biocompatibility. This study confirms that the PB@PMO‐Ce6 nanoplatform can generate more ROS to enhance PDT than free Ce6 in cellular level (p < 0.001). In vivo, the singlet oxygen sensor green staining, tumor volume of tumor‐bearing mice, and histopathological analysis demonstrate that this oxygen‐evolving nanoplatform can elevate singlet oxygen to effectively inhibit tumor growth without obvious damage to major organs. The preliminary results from this study indicate the potential of biocompatible PB@PMO‐Ce6 nanoplatform to elevate O2 and ROS for improving PDT efficacy.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Oxygen‐Evolving Mesoporous Organosilica Coated Prussian Blue Nanoplatform for Highly Efficient Photodynamic Therapy of Tumors

et al. 2018

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“…[24][25][26] The accumulated H 2 O 2 further transforms into highly cytotoxic hydroxyl radical (OH•) to significantly aggravate the oxidative damage and enhance PDT anticancer efficiency. [16,29,30] Thus, O 2 −• generator would be a promising alternative against hypoxic solid tumor treatment. [16,29,30] Thus, O 2 −• generator would be a promising alternative against hypoxic solid tumor treatment.…”

Section: Doi: 101002/advs201900530mentioning

confidence: 99%

A Bacteriochlorin‐Based Metal–Organic Framework Nanosheet Superoxide Radical Generator for Photoacoustic Imaging‐Guided Highly Efficient Photodynamic Therapy

et al. 2019

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Hypoxic tumor microenvironment is the bottleneck of the conventional photodynamic therapy (PDT) and significantly weakens the overall therapeutic efficiency. Herein, versatile metal–organic framework (MOF) nanosheets (DBBC‐UiO) comprised of bacteriochlorin ligand and Hf 6 (µ 3 ‐O) 4 (µ 3 ‐OH) 4 clusters to address this tricky issue are designed. The resulting DBBC‐UiO enables numerous superoxide anion radical (O 2 −• ) generation via a type I mechanism with a 750 nm NIR‐laser irradiation, part of which transforms to high toxic hydroxyl radical (OH•) and oxygen (O 2 ) through superoxide dismutase (SOD)‐mediated catalytic reactions under severe hypoxic microenvironment (2% O 2 ), and the partial recycled O 2 enhances O 2 −• generation. Owing to the synergistic radicals, it realizes advanced antitumor performance with 91% cell mortality against cancer cells in vitro, and highly efficient hypoxic solid tumor ablation in vivo. It also accomplishes photoacoustic imaging (PAI) for cancer diagnosis. This DBBC‐UiO, taking advantage of superb penetration depth of the 750 nm laser and distinct antihypoxia activities, offers new opportunities for PDT against clinically hypoxic cancer.

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“…[4d,f ] For the most reported type II PDT process, the excited triplet state can convert triplet oxygen ( 3 O 2 ) into cytotoxic singlet oxygen ( 1 O 2 ). [6] To solve this problem, O 2 self-supply methods are widely used to elevate the concentration of O 2 in tumors. Therefore, hypoxia originally pervades in solid tumors.…”

Section: Introductionmentioning

confidence: 99%

Monodispersed Copper(I)‐Based Nano Metal–Organic Framework as a Biodegradable Drug Carrier with Enhanced Photodynamic Therapy Efficacy

et al. 2019

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Photodynamic therapy (PDT) has emerged as an alternative treatment of cancers. However, the therapeutic efficiency of PDT is severely limited by the microenvironment of insufficient oxygen (O 2 ) supply and overexpression of glutathione (GSH) in the tumor. Herein, a biodegradable O 2 ‐loaded CuTz‐1@F127 (denoted as CuTz‐1‐O 2 @F127) metal–organic framework (MOF) therapeutic platform is presented for enhanced PDT by simultaneously overcoming intracellular hypoxia and reducing GSH levels in the tumor. The Cu(I)‐based MOF is capable of a Fenton‐like reaction to generate • OH and O 2 in the presence of H 2 O 2 under NIR irradiation. Meanwhile, the CuTz‐1‐O 2 @F127 nanoparticles (NPs) can release adsorbed O 2 , which further alleviates intracellular hypoxia. In addition, the Cu I in CuTz‐1@F127 can react with intracellular GSH to reduce the excess GSH. In this way, the efficiency of PDT is greatly enhanced. After tail intravenous injection, the NPs show high antitumor efficacy through a synergistic effect under 808 nm laser irradiation. More importantly, the NPs are biodegradable. In vivo biodistribution and excretion experiments demonstrate that a total of nearly 90% of the NPs can be excreted via feces and urine within 30 d, which indicates significant prospects in the clinical treatment of cancers.

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Continuous O₂-Evolving MnFe₂O₄ Nanoparticle-Anchored Mesoporous Silica Nanoparticles for Efficient Photodynamic Therapy in Hypoxic Cancer

Cited by 613 publications

References 33 publications

Oxygen‐Evolving Mesoporous Organosilica Coated Prussian Blue Nanoplatform for Highly Efficient Photodynamic Therapy of Tumors

Oxygen‐Evolving Mesoporous Organosilica Coated Prussian Blue Nanoplatform for Highly Efficient Photodynamic Therapy of Tumors

A Bacteriochlorin‐Based Metal–Organic Framework Nanosheet Superoxide Radical Generator for Photoacoustic Imaging‐Guided Highly Efficient Photodynamic Therapy

Monodispersed Copper(I)‐Based Nano Metal–Organic Framework as a Biodegradable Drug Carrier with Enhanced Photodynamic Therapy Efficacy

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