Continuous flow synthesis of β-amino α, β-unsaturated esters in aqueous medium

Joshi, Ramesh A.; Joshi, Rohini R.; Tibhe, J.; Nivangune, Nayana T.; Kulkarni, Amol A.

doi:10.1515/gps-2011-0002

Cited by 2 publications

(3 citation statements)

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“…One of the simplest designs is a pinched tube disclosed by Kulkarni and Ranade (Figure b). Pinched tubes have shown to offer enhanced heat transfer and reduced axial dispersion, which make them suitable for carrying out exothermic reactions. − Joshi et al have demonstrated safe operations with several multiphase exothermic reactions using pinched tube reactors. Andersson et al have developed a novel intensified reactor for liquid–liquid reactions that has eventually lead to a compact plate heat-exchanger cum reactor from Alfa Laval.…”

Section: Strategies For Intensificationmentioning

confidence: 99%

“…Joshi et al 39 have demonstrated the use of tubular reactors for very efficient synthesis of a large family of beta amino crotonates. The higher heat and mass transfer rates offered by the tubular reactors allow reactions at much higher temperatures compared to conventional semibatch reactors.…”

Section: ■ Tools and Examples Of Intensification Of Multiphase Reacti...mentioning

confidence: 99%

“…Pinched tube reactorsand AmAR reactors[35] have been extensively used for intensifying several multiphase reactions including nitration[52] and diazotization[53]. These MAGIC tubes derived from commercially available tubing can significantly reduce the cost of manufacturing while retaining major advantages offered by narrow channel reactors.Joshi et al[39] have demonstrated the use of tubular reactors for very efficient synthesis of a large family of beta amino crotonates. The higher heat and mass transfer rates offered by the tubular reactors allows reactions at much higher temperatures compared to conventional semi-batch reactors.…”

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confidence: 99%

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Intensifying Multiphase Reactions and Reactors: Strategies and Examples

Utikar

Ranade²

2017

ACS Sustainable Chem. Eng.

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Intensification is intrinsic to better chemical and process engineering and has always been used in practice. Multiphase reactions and reactors are ubiquitous in chemical and allied industries and are of great economic and ecological importance. There is a great scope for intensifying multiphase reactions and reactors for realizing productivity enhancements, which are crucial for sustainable manufacturing. These enhancements can be in terms of increased throughput; better yield, conversion, and selectivity; smaller environmental footprint; and intrinsically safer operations. The advances in intensified reactors especially micro-reactors and microfluidic devices have created significant awareness about intensification in recent decades. In this note, we discuss different strategies for intensifying multiphase reactions and reactors based on the published information. Variety of tools and examples are presented to showcase the potential of intensification. We have found the efforts towards intensification of multiphase reactions and reactors very rewarding academically as well as professionally. We hope that this note will further stimulate interest in this area and pave the way towards realizing next generation productivity for chemical and allied industries.

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Section: Strategies For Intensificationmentioning

confidence: 99%

Section: ■ Tools and Examples Of Intensification Of Multiphase Reacti...mentioning

confidence: 99%

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Intensifying Multiphase Reactions and Reactors: Strategies and Examples

Utikar

Ranade²

2017

ACS Sustainable Chem. Eng.

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Highlights from the Flow Chemistry Literature 2012 (Part 2)

Glasnov

2012

J Flow Chem

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In this section of the journal, the continuous flow chemistry literature of the preceding months is presented. Included are articles published in the period March-June 2012. Some key examples are highlighted in the form of graphical abstracts. The remaining publications in the field are then listed ordered by journal name, with review articles grouped at the end. In continuous-flow synthesis as well as in a batch process, purification is a bottleneck, which can negatively affect the benefits of the whole synthetic procedure. The use of solid-supported scavengers for in-line purification works well for small laboratory applications but fails in an industrially relevant scale due to the finite lifetime. A combination of a flow process and automated simulated moving-bed chromatography (SMBC) is presented as a possible solution to this problem. A Vapourtec flow instrument is combined with an SMBC system for the optimization and purification of a S N Ar-synthesis in order to separate the desired product from the by-products. The final conditions delivered 98% yield of the purified product. A robust polymer-supported amino alcohol ligand for the highly enantioselective alkylation of aldehydes using diethylzinc has been developed. Eleven different substrates were tested to deliver good to high yields and high enantioselectivity. In a single continuous-flow experiment, 13 g of enantiopure alcohol was isolated, corresponding to a TON of 251 and a productivity of 6.4 mmol/(h⋅g resin ), which is a 30-fold increase in comparison to the TON of a comparable batch experiment. The flow experiment had a dramatic effect on the reaction time as compared to batch-6 min vs. 6 h.

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Continuous flow synthesis of β-amino α, β-unsaturated esters in aqueous medium

Cited by 2 publications

References 8 publications

Intensifying Multiphase Reactions and Reactors: Strategies and Examples

Intensifying Multiphase Reactions and Reactors: Strategies and Examples

Highlights from the Flow Chemistry Literature 2012 (Part 2)

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