Continuous drying of a protein-type drug using scaled-up fiber formation with HP-β-CD matrix resulting in a directly compressible powder for tableting

Vass, Panna; Nagy, Zsombor Kristóf; Kóczián, Rita; Fehér, Csaba; Démuth, Balázs; Szabó, Edina; Andersen, Sune Klint; Vígh, Tamás; Verreck, Geert; Csontos, István; Marosi, György; Hirsch, Edit

doi:10.1016/j.ejps.2019.105089

Cited by 23 publications

(22 citation statements)

References 29 publications

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“…The similar encapsulation efficiency values of EE% (i.e., 98.1 ± 6.4% and 97.5 ± 7.1% for N1 and N2, respectively) suggest that the electrospinning is essentially a physical drying process without any drug loss to the environment, although reactive electrospinning has been reported in literature [ 52 , 53 , 54 ]. Drying at an extremely rapid rate should be a unique advantage of electrospinning over many other bottom-up methods used for creating nanomedicines [ 55 , 56 ].…”

Section: Resultsmentioning

confidence: 99%

Energy-Saving Electrospinning with a Concentric Teflon-Core Rod Spinneret to Create Medicated Nanofibers

et al. 2020

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Although electrospun nanofibers are expanding their potential commercial applications in various fields, the issue of energy savings, which are important for cost reduction and technological feasibility, has received little attention to date. In this study, a concentric spinneret with a solid Teflon-core rod was developed to implement an energy-saving electrospinning process. Ketoprofen and polyvinylpyrrolidone (PVP) were used as a model of a poorly water-soluble drug and a filament-forming matrix, respectively, to obtain nanofibrous films via traditional tube-based electrospinning and the proposed solid rod-based electrospinning method. The functional performances of the films were compared through in vitro drug dissolution experiments and ex vivo sublingual drug permeation tests. Results demonstrated that both types of nanofibrous films do not significantly differ in terms of medical applications. However, the new process required only 53.9% of the energy consumed by the traditional method. This achievement was realized by the introduction of several engineering improvements based on applied surface modifications, such as a less energy dispersive air-epoxy resin surface of the spinneret, a free liquid guiding without backward capillary force of the Teflon-core rod, and a smaller fluid–Teflon adhesive force. Other non-conductive materials could be explored to develop new spinnerets offering good engineering control and energy savings to obtain low-cost electrospun polymeric nanofibers.

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Section: Resultsmentioning

confidence: 99%

Energy-Saving Electrospinning with a Concentric Teflon-Core Rod Spinneret to Create Medicated Nanofibers

et al. 2020

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“…Cyclodextrins form strong aggregates in their concentrated solutions, and the intermolecular interactions make it possible to electrospin cyclodextrin solutions into fibers. Previous studies showed that hydroxypropyl-β-cyclodextrin fibers can be produced from aqueous solutions with 61.5 w/w% (single-needle electrospinning) ( 41 ) and 67.4 w/w% (HSES) ( 28 ) concentrations. Electrospinning of hydroxypropyl-β-cyclodextrin solutions containing sporulated and vegetative C. butyricum was attempted using the high-speed electrospinning device, and the fiber formation could be performed seamlessly.…”

Section: Resultsmentioning

confidence: 99%

Electrospun Solid Formulation of Anaerobic Gut Microbiome Bacteria

et al. 2020

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A model anaerobic bacterium strain from the gut microbiome ( Clostridium butyricum ) producing anti-inflammatory molecules was incorporated into polymer-free fibers of a water-soluble cyclodextrin matrix (HP-β-CD) using a promising scaled-up nanotechnology, high-speed electrospinning. A long-term stability study was also carried out on the bacteria in the fibers. Effect of storage conditions (temperature, presence of oxygen) and growth conditions on the bacterial viability in the fibers was investigated. The viability of the sporulated anaerobic bacteria in the fibers was maintained during 12 months of room temperature storage in the presence of oxygen. Direct compression was used to prepare tablets from the produced bacteria-containing fibers after milling (using an oscillating mill) and mixing with tableting excipients, making easy oral administration of the bacteria possible. No significant decrease was observed in bacterial viability following the processing of the fibers (milling and tableting).

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“…A very effective collection after high‐speed ES can be performed by a cyclone, similarly to spray drying (Figure ; Vass, Démuth, Farkas, et al, ; Vass et al, ). The fast circular motion of the fibers in the cyclone results in their fragmentation.…”

Section: Downstream Processing Of the Electrospun Fibersmentioning

confidence: 99%

“…Schematic drawing and photo of a nozzle‐based high‐speed ES machine equipped with cyclone collecting the produced fibers (Vass et al, ). ES, electrospinning…”

Section: Downstream Processing Of the Electrospun Fibersmentioning

confidence: 99%

“…The morphology and the dissolution properties of the produced fibrous mats showed similarity to the samples prepared by SNES. It has been shown that rational selection of the applied polymer can ensure the Vass et al (2020) stability of the amorphous drug in the matrix which meets the strict requirements of the pharmaceutical industry . The technology proved to be appropriate for the formation of flubendazole containing electrospun product as well (Vigh et al, 2017).…”

Section: Free Surface Esmentioning

confidence: 99%

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Scale‐up of electrospinning technology: Applications in the pharmaceutical industry

Vass

Szabó

Domokos

et al. 2019

WIREs Nanomed Nanobiotechnol

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146

106

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Recently, electrospinning (ES) of fibers has been shown to be an attractive strategy for drug delivery. One of the main features of ES is that a wide variety of drugs can be loaded into the fibers to improve their bioavailability, to enhance dissolution, or to achieve controlled release. Besides, ES is a continuous technology with low energy consumption, which can make it a very economic production alternative to the widely used freeze drying and spray drying. However, the low production rate of laboratory‐scaled ES has limited the industrial application of the technology so far. This article covers the various ES technologies developed for scaled‐up fiber production with an emphasis on pharmaceutically relevant examples. The methods used for increasing the productivity are complied, which is followed by a review of specific examples from literature where these technologies are utilized to produce oral drug delivery systems. The different technologies are compared in terms of their basic principles, advantages, and limitations. Finally, the different downstream processing options to prepare tablets or capsules containing the electrospun drug are covered as well. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies

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Continuous drying of a protein-type drug using scaled-up fiber formation with HP-β-CD matrix resulting in a directly compressible powder for tableting

Cited by 23 publications

References 29 publications

Energy-Saving Electrospinning with a Concentric Teflon-Core Rod Spinneret to Create Medicated Nanofibers

Energy-Saving Electrospinning with a Concentric Teflon-Core Rod Spinneret to Create Medicated Nanofibers

Electrospun Solid Formulation of Anaerobic Gut Microbiome Bacteria

Scale‐up of electrospinning technology: Applications in the pharmaceutical industry

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