Cell Reports volume 5, issue 4, P1022-1035 2013 DOI: 10.1016/j.celrep.2013.10.022 View full text
|
|
Share
Julia Jellusova, Ana V. Miletic, Matthew H. Cato, Wai-Wai Lin, Yinling Hu, Gail A. Bishop, Mark J. Shlomchik, Robert C. Rickert

Abstract: Summary BAFF is a soluble factor required for B cell maturation and survival. BAFF-R signals via the non-canonical NF-κB pathway regulated by the TRAF3/NIK/IKK1 axis. We show that deletion of Ikk1 during early B cell development causes a partial impairment in B cell maturation and BAFF-dependent survival, but inactivation of Ikk1 in mature B cells does not affect survival. We further show that BAFF-R employs CD19 to promote survival via PI3K, and that co-inactivation of Cd19 and Ikk1 causes a profound block i…

expand abstract