Contemporary Management Of Stage T1 Transitional Cell Carcinoma Of The Bladder

Soloway, Mark S.; Sofer, Mario; Vaidya, Anil

doi:10.1097/00005392-200204000-00003

Cited by 52 publications

(58 citation statements)

References 121 publications

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“…In accordance, others have found that the false-positive rates vary greatly between institutions [13,14], 4–53%, which might be the result of a different PDD qualities [15]. Similarly, the rate of tumor residuals found at second look TURBT also varies greatly among hospitals and urologists, 27–78% [16,17,18]. Many of the residual tumors (54%) are found outside the primary resection site [19] which would suggest that tumors can be overlooked by urologists.…”

Section: Discussionmentioning

confidence: 53%

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The Quality of 5-Aminolevulinic Acid-Induced Photodynamic Diagnosis and Transurethral Resection of Bladder Tumors: Does the Urologist Play a Role?

Draga¹,

Grimbergen²,

Kok³

et al. 2012

Urol Int

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Introduction: The aim of this study is to evaluate the quality of photodynamic diagnosis (PDD) and transurethral resection of bladder tumors (TURBT) among different urologists. Patients and Methods: The selected data consists of 194 patients, 268 5-aminolevulinic acid (5-ALA)-induced PDD procedures and 934 biopsies. Tumors were resected and biopsies were taken from suspicious areas under guidance of white light endoscopy and 5-ALA-induced fluorescence cystoscopy. The quality of PDD was determined by evaluating the mean number of tumors resected by 5 urologists and, thereafter, assessing the time to recurrence between groups. Results: Urologist 1 took 37% more biopsies (p < 0.001) and diagnosed 42% more tumors (p = 0.005) and 46% more false positives (p < 0.001) from bladders compared to urologists 2, 3, 4 and 5 together. The mean time to bladder cancer recurrence for all recurrences within 0–18 months was 11.0 months for operator 1 and 8.3 months for the other urologists (p = 0.01). Conclusions: The resecting urologist appears to be an important factor for the quality of standard and PDD-assisted TURBT. Learning curve programs may be required with experienced surgeons accompanying those with less experience.

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Section: Discussionmentioning

confidence: 53%

“…Third, the bladder volume is maintained at 50–75% capacity during TURBT to improve the identification of carcinoma in situ. In addition, overfilling of the bladder increases the risk of bleeding which impairs inspection of the bladder mucosa [16]. …”

Section: Discussionmentioning

confidence: 99%

The Quality of 5-Aminolevulinic Acid-Induced Photodynamic Diagnosis and Transurethral Resection of Bladder Tumors: Does the Urologist Play a Role?

Draga¹,

Grimbergen²,

Kok³

et al. 2012

Urol Int

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“…Progression to muscle invasion occurs in about 15-20% of cases [12], taken all different groups of pTa (PUNLMP, NILGC, NIHGC). Especially, NIHGC has a high rate of progression that varies between 23 and 65% in different studies [20,40]. pT1 tumors progress in up to 30% of cases [16].…”

Section: Discussionmentioning

confidence: 99%

“…PTa bladder cancers have a variable recurrence rate and progression [13,16,20,40]. In papillary urothelial neoplasm of low malignant potential (PUNLMP) or non-invasive papillary urothelial carcinoma low grade (NILGC), recurrence varies from 25 to 70%, and few progress towards higher grade or invasive tumors.…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical expression of p63, p53 and MIB-1 in urinary bladder carcinoma. A tissue microarray study of 158 cases

et al. 2005

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P63 is a member of the p53 family, which plays a role in the differentiation of urothelium and is supposed to play a role in urothelial carcinogenesis. P53 and MIB-1 are recognised in many studies as predictive markers of progression, but few studies in the literature have examined p63. The aims of our study were to explore the expression of p63 in bladder carcinomas and to compare this expression to p53 and MIB-1, as well as to stage and grade. Tissue microarrays were performed on 158 urothelial carcinomas (56 pTa, 45 pT1 and 57>or=pT2). Immunohistochemical studies were performed with p63, p53 and MIB-1 antibodies. In our study we observed that p63 immunostaining is present in all cell layers in papillary urothelial neoplasm of low malignant potential (PUNLMP), but partially lost in non-invasive papillary urothelial carcinoma low grade (NILGC) and in pT1/>or=pT2 bladder cancers. P53 and MIB-1 displayed lower expression in PUNLMP/NILGC vs non-invasive papillary urothelial carcinoma high grade (NIHGC)/pT1, but there was no correlation between the expression of p63, p53 and MIB-1. Our study demonstrates that p63 expression distinguishes between PUNLMP/NILGC and NIHGC/pT1 (p=4.10(5)). A statistical difference disserving pTa and pT1/>or=pT2 with a statistical significance (p<10(-6)) could also be observed. P63 should be considered as an additional biomarker that might help pathologists to classify their patients.

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“…Bacillus Calmette-Guérin (BCG) is a well-known anticancer agent for intravesical instillation the effectiveness of which has been established for patients with carcinoma in situ (CIS) or superficial non-muscle-invasive high-grade bladder tumors [5,6]. However, this immunotherapy is not generally indicated for single or multiple low-grade tumors.…”

Section: Introductionmentioning

confidence: 99%

Double short-time exposure to pirarubicin produces higher cytotoxicity against T24 bladder cancer cells

Maruyama

Higuchi

Suzuki

et al. 2011

Journal of Infection and Chemotherapy

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Contemporary Management Of Stage T1 Transitional Cell Carcinoma Of The Bladder

Cited by 52 publications

References 121 publications

The Quality of 5-Aminolevulinic Acid-Induced Photodynamic Diagnosis and Transurethral Resection of Bladder Tumors: Does the Urologist Play a Role?

The Quality of 5-Aminolevulinic Acid-Induced Photodynamic Diagnosis and Transurethral Resection of Bladder Tumors: Does the Urologist Play a Role?

Immunohistochemical expression of p63, p53 and MIB-1 in urinary bladder carcinoma. A tissue microarray study of 158 cases

Double short-time exposure to pirarubicin produces higher cytotoxicity against T24 bladder cancer cells

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