Contamination Controls for Analysis of Root Canal Samples by Molecular Methods: An Overlooked and Unsolved Problem

Immediate clinical and microbiological evaluation of the effectiveness of 0.5% versus 3% sodium hypochlorite in root canal treatment: A quasi‐randomized controlled trial

“…Contamination (positive sterility check) in the sampling technique used was scarce, and, when the analysis was adjusted due to contamination, the results did not change significantly. However, an important finding was the significantly higher risk of a positive sample and culture in the cases of a contaminated operation field (RR = 3.81; P < 0.0001), indicating the importance of the control and documentation of contaminated cases when culturing is used as an outcome in the studies of different protocols for root canal treatment (Figdor & Brundin ). From a clinical point of view, the findings illustrate the importance of strict asepsis to achieve a root canal free from cultivable bacteria prior to root filling.…”

The impact of Distinctive Root Canal Instrumentation Systems on Endotoxin Lessening from the Root Canal: A Systematic Review and Meta-Analysis

“…In addition, the microbiological consideration showed high sensitivity at each arranges of assessment. Moreover, the baseline values and sterility check have been considered the crucial factors utilized to improve the research plan's accuracy and approve the outcome validity [23].…”

Effect of instrumentation systems on endotoxin reduction from root canal systems: A systematic review of clinical studies and meta‐analysis

“…Microbiological studies are very sensitive at every stage of evaluation. Baseline values and sterility checks are essential parameters used to enhance the robustness of the study design and confirm the validity of results . All included studies provided baseline values of endotoxin and performed surface disinfection of the tooth and after access cavity preparation .…”