1980
DOI: 10.1001/archderm.116.1.74
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Contact urticaria from cinnamic aldehyde

Abstract: Lip swelling developed following the use of a cinnamic aldehyde-containing mouthwash in a woman with allergic rhinitis and asthma. Open application of the mouthwash on the antecubital fossae of the patient and control subjects produced immediate erythematous or urticarial responses in all tested individuals. Subsequent investigation established cinnamic aldehyde as the responsible ingredient. The incidence of positive reactions was shown to depend on site of application, vehicle, concentration, and time of rea… Show more

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Cited by 16 publications
(3 citation statements)
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“…Moreover, the interest in this essential oil is increasing because of its fungitoxic properties against various Aspergillus species which are implicated in mycoses of the respiratory tract (Montes-Belmont and Carvajal, 1998). The use of the essential oil from Cinnamomum cassia in therapy will need to have take into account the allergenic power of this oil and its components (Mathias et al, 1980;Goh and Ng, 1988). Clinical observations of toxicity linked to the ingestion of essential oil of cinnamon showed limited and reversible damage (Pilapil, 1983;Perry and Dean, 1990).…”
Section: Resultsmentioning
confidence: 99%
“…Moreover, the interest in this essential oil is increasing because of its fungitoxic properties against various Aspergillus species which are implicated in mycoses of the respiratory tract (Montes-Belmont and Carvajal, 1998). The use of the essential oil from Cinnamomum cassia in therapy will need to have take into account the allergenic power of this oil and its components (Mathias et al, 1980;Goh and Ng, 1988). Clinical observations of toxicity linked to the ingestion of essential oil of cinnamon showed limited and reversible damage (Pilapil, 1983;Perry and Dean, 1990).…”
Section: Resultsmentioning
confidence: 99%
“…In a susceptible host, mouthwashes have also been shown to produce hypersensitive reactions, triggered by a range of ingredients. Hypersensitive reactions triggered by mouthrinses have been reported in the literature ( 38 , 39 , 40 ). Mathias et al( 39 ) reported a case of contact urticaria that developed after use of a cinnamic aldehyde-containing mouthwash in which lip swelling occurred.…”
Section: Introductionmentioning
confidence: 99%
“…The literature cites metals, antiseptics, resins, flavour ing substances and local anaesthetics [1], Immediate reactions such as contact urticaria have been observed after application of a paraformaldehydecontaining root canal filling paste [2] and the use of tooth paste containing cinnamic aldehyde [3].…”
mentioning
confidence: 99%