Contact sensitization to modern dressings: a multicentre study on 354 patients with chronic leg ulcers

Valois, A.; Waton, J.; Avenel-Audran, M.; Truchetet, F.; Collet, E.; Raison‐Peyron, Nadia; Cuny, J.-F.; Bethune, Benjamin; Schmutz, J.‐L.; Barbaud, A.

doi:10.1111/cod.12307

Cited by 54 publications

(38 citation statements)

References 30 publications

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“…Allergic contact dermatitis to synthetic rubber, neoprene, in compression stockings has been reported . Modern dressing‐related contact dermatitis is infrequent but has also been reported . Usage of these modern dressings is infrequent in Indian patients, and hence, sensitisation may be a rare occurrence.…”

Section: Discussionmentioning

confidence: 99%

Contact sensitivity in patients with venous leg ulcer: A multi‐centric Indian study

Rai

Shenoy

Viswanath

et al. 2018

International Wound Journal

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Venous leg ulcers are the most common form of non-healing leg ulcers. They are subjected to treatments such as topical medications, dressings, and compression therapies. This can lead to exposure to a number of allergens with subsequent sensitisation and contact dermatitis of the regional skin. This may contribute to the poor ulcer healing. To detect the various contact sensitisers in patients with venous leg ulcers through patch testing, patients from 6 centres across India with venous leg ulcers of longer than 6 weeks duration were enrolled for the study. They were patch tested using a special parch test kit with 27 antigens. A total of 172 patients were included in the study; 82 (48.2%) tested positive for at least 1 antigen. Among them, polyvalent sensitisation was noted in 71% of patients. Wood tar mix (10.4%) and the framycetin (8.7%) were the most common allergens. There is a high frequency of allergic sensitisation to various ingredients of topical therapies used in the venous ulcer management, which may interfere with wound healing. Avoiding them can help obtain a better therapeutic outcome.

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Section: Discussionmentioning

confidence: 99%

Contact sensitivity in patients with venous leg ulcer: A multi‐centric Indian study

Rai

Shenoy

Viswanath

et al. 2018

International Wound Journal

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“…2 The North American Contact Dermatitis Group identified that 1.5% to 9.1% of patch-tested patients older than 20 years are allergic to bacitracin, and 7.2% to 13.1% of patch-tested patients older than 20 years have allergic sensitization to neomycin. 6 The number of positive patch test was correlated with the duration of ulcerative disease and independent of ulcer etiology (venous, arterial, or mixed arteriovenous). 6 The number of positive patch test was correlated with the duration of ulcerative disease and independent of ulcer etiology (venous, arterial, or mixed arteriovenous).…”

Section: Review Of the Current Literaturementioning

confidence: 93%

“…[3][4][5] In a recent study on 354 patients with CLUs, the percentage of positive patch test to modern wound-related materials was reported as high as 59.6%. 6 The top 5 common allergens in 5 studies from 2009 to 2015 include balsam of Peru, lanolin, amerchol, fragrance mix, and benzocaine (Table 2). 6 The top 5 common allergens in 5 studies from 2009 to 2015 include balsam of Peru, lanolin, amerchol, fragrance mix, and benzocaine (Table 2).…”

Section: Review Of the Current Literaturementioning

confidence: 99%

“…Also, soft silicone-faced polyurethane foam dressings, polyurethane foam self-adhesive island dressings, and soft hydrophilic polyurethane foam dressings had low mean transepidermal water loss values closer to that of normal skin. 6,14 Pentaerythritol ester of the hydrogenated resin is not commercially available for patch testing and should be tested with a small piece (1 cm 2 ) of the suspected hydrocolloid dressing applied to the skin for 48 hours with fixed erythema on the covered skin when the dressing is removed. 9 Colophony or resin is extracted from conifer trees, usually pine species.…”

Section: Review Of the Current Literaturementioning

confidence: 99%

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Wound-Related Allergic/Irritant Contact Dermatitis

Alavi

Sibbald

Ladizinski

et al. 2016

Advances in Skin &Amp; Wound Care

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Contact dermatitis to wound care products is a common, often neglected problem. A review was conducted to identify articles relevant to contact dermatitis.A PubMed English-language literature review was conducted for appropriate articles published between January 2000 and December 2015.Contact dermatitis is both irritant (80% of cases) or allergic (20% of cases). Frequent use of potential contact allergens and impaired barrier function of the skin can lead to rising sensitization in patients with chronic wounds. Common known allergens to avoid in wound care patients include fragrances, colophony, lanolin, and topical antibiotics.Clinicians should be cognizant of the allergens in wound care products and the potential for sensitization. All medical devices, including wound dressings, adhesives, and bandages, should be labeled with their complete ingredients, and manufacturers should be encouraged to remove common allergens from wound care products, including topical creams, ointments, and dressings.

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“…Around 70 % of patients with chronic wounds showed at least one contact sensitization when undergoing patch testing (27). Duration of ulcerative diseases, frequent use of different topical ointments for the surrounding skin and numerous changes in wound dressing materials are seen as risk factors for contact dermatitis.…”

Section: Inflammatory Skin Diseasesmentioning

confidence: 99%

Chronic wounds – Recommendations for diagnostics and therapy

Erfurt‐Berge

Renner

2015

Reviews in Vascular Medicine

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Contact sensitization to modern dressings: a multicentre study on 354 patients with chronic leg ulcers

Abstract: Sensitization to MDs is not rare. It is absolutely necessary to label all components of MDs on their packaging and to avoid some sensitizing molecules, such as colophonium derivatives or any strong sensitizers.

Cited by 54 publications

References 30 publications

Contact sensitivity in patients with venous leg ulcer: A multi‐centric Indian study

Contact sensitivity in patients with venous leg ulcer: A multi‐centric Indian study

Wound-Related Allergic/Irritant Contact Dermatitis

Chronic wounds – Recommendations for diagnostics and therapy

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