Contact sensitivity to the amide anesthetics lidocaine, prilocaine, and mepivacaine. Case report and review of the literature

Delayed-Type Hypersensitivity to Lidocaine

“…The authors concluded that there was cross-sensitivity to prilocaine and mepivacaine as a result of lidocaine exposure, since the patient had never been exposed to these chemicals until the dates of the reactions. 6 Bircher et al 20 also reported a patient with localized swelling 24 hours after dental surgery, with patch tests revealing lidocaine sensitivity.…”

“…5 Amide anesthetics include the aminoacylamides lidocaine, mepivacaine, and prilocaine as well as the aminoalkylamides procainamide and dibucaine. 6 The most commonly used anesthetic agent for dermatologic surgery is lidocaine. It is also known as lignocaine in the European literature.…”

“…In the literature, type I reactions are much more common than delayed-type hypersensitivity reactions. 6 There are a limited number of reported cases of contact sensitivity to lidocaine. The first case report was by Calnan and Stevenson 8 in 1954, describing a chemical process worker involved in the production of lidocaine.…”

“…19 There are a few cases reported in the literature in which patients developed a type IV hypersensitivity reaction to a therapeutic injection of lidocaine. Curley et al 6 presented a dental patient who developed swelling of her soft tissues 48 hours after lidocaine injection for a (REPRINTED) ARCH DERMATOL / VOL 139, MAR 2003 WWW.ARCHDERMATOL.COMdental procedure. She had a similar reaction to prilocaine and, later, mepivacaine injections for further dental procedures.…”

Skin Conditions of Baseball, Cricket, and Softball Players

“…Contact allergens in baseball, cricket, and softball apparel or equipment[88,[129][130][131][132][133][134][135][136][137][138][139][140][141][142][143] …”