Contact Dermatitis to Pentylene Glycol in a Prescription Cream for Atopic Dermatitis: Case Report

Allergic contact dermatitis to ethylhexylglycerin and pentylene glycol

“…Pentylene glycol also has antimicrobial effects. Few cases of allergic contact dermatitis to this allergen have been published (3–6). We did not find any reaction to propylene glycol in our patient in accordance with other authors (3–5), although cross‐reactions between glycols are a theoretical possibility.…”

Allergic contact dermatitis to pentylene glycol in an eye contour cream

“…Reports of contact allergy to pentylene glycol are rare . To our knowledge, this preservative is not commercially available as a patch test allergen, and sensitization to it is likely to pass undetected unless specifically looked for.…”

“…Reports of contact allergy to pentylene glycol are rare. [1][2][3][4][5][6] To our knowledge, this preservative is not commercially available as a patch test allergen, and sensitization to it is likely to pass undetected unless specifically looked for. The severity of the clinical picture in our patient suggests that its allergenic potential may be stronger than hitherto suspected, particularly when it is contained in cosmetics meant for delicate areas such as the eyelids.…”

Allergic contact dermatitis to propyl gallate and pentylene glycol in an emollient cream

“…It is often used as an alternative for propylene glycol (1,2‐propanediol), having similar properties but associated with a lower risk of irritation and sensitization. Allergic reactions to pentylene glycol have been rarely described 2–5 . Pentylene glycol and propylene glycol share the same chemical structure with the exception of a longer carbon chain on the former molecule and the relative position of the alcohol groups.…”