Consumption of diacylglycerol oil as part of a reduced-energy diet enhances loss of body weight and fat in comparison with consumption of a triacylglycerol control oil

Maki, Kevin C.; Davidson, Michael; Tsushima, Rikio; Matsuo, Noboru; Tokimitsu, Ichiro; Umporowicz, Denise M; Dicklin, Mary R.; Foster, Gregory S.; Ingram, Kate A.; Anderson, Barbara; Frost, Scott D; Bell, Marjorie

doi:10.1093/ajcn/76.6.1230

Cited by 257 publications

(153 citation statements)

References 21 publications

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“…The intake of certain beverages and functional foods has been shown to be effective at the suppression or reduction of body fat accumulation (Maki et al, 2002;Nosaka et al, 2003;Ikeda et al, 2005). Rats who were fed CBE, which contains 10.0% caffeine and 27.0% chlorogenic acid as the principal constituents, showed suppressed body weight gain irrespective of food and energy intake compared to those fed the control diet not containing CBE (CBE group: 82.3 ± 3.6 kcal/day; control group: 86.8 ± 2.0 kcal/day).…”

Section: Discussionmentioning

confidence: 99%

Anti-Obesity and Hypotriglyceridemic Properties of Coffee Bean Extract in SD Rats

Tanaka

Nishizono

Tamaru

et al. 2009

FSTR

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Coffee bean extract (CBE) was prepared from raw green coffee beans and contained 10.0% caffeine and 27.0% chlorogenic acid. Male Sprague-Dawley rats were fed a diet containing 1% CBE for 4 weeks. Although there was no difference in food intake between rats fed the control diet without CBE and those fed the CBE-containing diet, body weight gain and white adipose tissue weight were significantly decreased in CBE-fed rats than in control rats. The CBE-fed group exerted a significant and extreme reduction in serum and liver triglyceride concentrations compared to the control group. Also, in the CBE-fed group, activities of fatty acid synthetic enzymes in the hepatic cytosol were significantly decreased, while that of fatty acid oxidative enzymes in the hepatic mitochondria was significantly increased. Our results suggest that CBE has potent anti-obesity and hypotriglyceridemic properties, and there is a possibility that these effects are exerted at least in part by the suppression of lipogenesis and the acceleration of lipolysis.

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Section: Discussionmentioning

confidence: 99%

Anti-Obesity and Hypotriglyceridemic Properties of Coffee Bean Extract in SD Rats

Tanaka

Nishizono

Tamaru

et al. 2009

FSTR

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“…11 Human studies in the US and Japan have demonstrated that long-term consumption of a diet containing DAG oil enhances loss of body weight and BF compared with a TAG oil with a similar fatty acid composition. 12,13 Animal studies have shown that both b-oxidation and expression of lipid metabolism-related genes in the liver and small intestine are enhanced with chronic DAG oil ingestion compared with TAG oil ingestion. [14][15][16] Several human studies have shown greater fat oxidation and/or lower respiratory quotient with short-term DAG oil consumption (single meal, 17 1 8 and 4 days 18 ) compared with TAG oil consumption.…”

Section: Introductionmentioning

confidence: 99%

“…The purpose of this study was to determine whether repeated DAG oil consumption affects energy metabolism in overweight patients in a 14-day controlled feeding study. Simultaneously, we explored the effect of DAG oil consumption on dietary fat oxidation, as determined by the recovery rate of 13 C-stable isotope in the breath.…”

Section: Introductionmentioning

confidence: 99%

“…The glyceride composition of each probe was determined by gas-liquid chromatography. 13 C-labeled triolein at a dose of 900 mg was added to both the DAG oiland TAG oil-containing breakfasts consumed at 0900 hours. Breath samples were collected in aluminum bags (GL Science Inc., Tokyo, Japan) before breakfast, hourly for a period of 10 h, and again after 15 and 22 h. Enrichment of 13 CO 2 in the patient's breath was analyzed by isotope ratio mass spectrometry (Sercon, ANCA-GSL, Cheshire, UK).…”

mentioning

confidence: 99%

“…Breath samples were collected in aluminum bags (GL Science Inc., Tokyo, Japan) before breakfast, hourly for a period of 10 h, and again after 15 and 22 h. Enrichment of 13 CO 2 in the patient's breath was analyzed by isotope ratio mass spectrometry (Sercon, ANCA-GSL, Cheshire, UK). Rates of 13 …”

mentioning

confidence: 99%

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Greater fat oxidation with diacylglycerol oil consumption for 14 days compared with triacylglycerol oil consumption in overweight men and women

et al. 2008

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Structural Effects on Absorption, Metabolism, and Health Effects of Lipids

Christophe

2005

Bailey's Industrial Oil and Fat Products

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The structure of fatty acid‐containing lipid classes is defined as the grouping or positioning of fatty acids on the alcohol backbone. Alcohol backbones considered are glycerol, phytosterols/‐stanols, and sucrose. Health‐related nutritional effects of food lipids depend on the fatty acids they contain (not covered here), on the alcohol backbone, on the number of fatty acids esterified on the alcohol backbone if applicable (triacylglycerols vs. diacylglycerols vs. monoacylglycerols), and on the position the fatty acids occupy. The specificity of the lipases that are present in the intestinal tract are a major determinant of the digestion products that will be formed. Different digestion products will react differently in the intestinal lumen and after absorption will be metabolized differently in the intestinal cells. Specificity of lipases in combination with different handling of different fat digestion products are at the basis of structure‐related effects of food lipids. The position of fatty acids in triacylglycerols (inner or outer) can have an effect on digestibility (for saturated fatty acids), route of transport (for medium chain fatty acids), conversion in higher unsaturated fatty acids (for parent essential fatty acids), chylomicronemia, cholesterolemia, and atherogenicity. The well‐known cholesterolemic and atherogenic effects of different fatty acids are more pronounced when these fatty acids are esterified at the inner position of triglycerides. Partial glycerides have nutritional effects different from triglycerides with the same fatty acid composition. The nature of the alcohol backbone of food fats is also extremely important for their health‐related nutritional effects. Phytosterol/‐stanol esters, for instance, have cholesterol‐lowering effects, and sucrose polyesters cannot be absorbed from the intestinal tract.

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Consumption of diacylglycerol oil as part of a reduced-energy diet enhances loss of body weight and fat in comparison with consumption of a triacylglycerol control oil

Abstract: Foods containing diacylglycerol oil promoted weight loss and body fat reduction and may be useful as an adjunct to diet therapy in the management of obesity.

Cited by 257 publications

References 21 publications

Anti-Obesity and Hypotriglyceridemic Properties of Coffee Bean Extract in SD Rats

Anti-Obesity and Hypotriglyceridemic Properties of Coffee Bean Extract in SD Rats

Greater fat oxidation with diacylglycerol oil consumption for 14 days compared with triacylglycerol oil consumption in overweight men and women

Structural Effects on Absorption, Metabolism, and Health Effects of Lipids

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