Consumption of a Western-style diet during pregnancy impairs offspring islet vascularization in a Japanese macaque model

Pound, Lynley D.; Comstock, Sarah M.; Grove, Kevin L.

doi:10.1152/ajpendo.00131.2014

Cited by 42 publications

(47 citation statements)

References 61 publications

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“…Administration of RESV pre‐conception and throughout pregnancy to obese macaques increased pancreatic islet capillary density (Pound et al . ), as well as pancreatic mass and β‐cell proliferation in the fetus (Roberts et al . ).…”

Section: Discussionmentioning

confidence: 99%

Maternal resveratrol administration protects against gestational diabetes‐induced glucose intolerance and islet dysfunction in the rat offspring

Brawerman

Kereliuk

Brar

et al. 2019

The Journal of Physiology

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Key points Maternal resveratrol (RESV) administration in gestational diabetes (GDM) restored normoglycaemia and insulin secretion. GDM‐induced obesity was prevented in male GDM+RESV offspring but not in females. GDM+RESV offspring exhibited improved glucose tolerance and insulin sensitivity. GDM+RESV restored hepatic glucose homeostasis in offspring. Glucose‐stimulated insulin secretion was enhanced in GDM+RESV offspring. Abstract Gestational diabetes (GDM), the most common complication of pregnancy, is associated with adverse metabolic health outcomes in offspring. Using a rat model of diet‐induced GDM, we investigated whether maternal resveratrol (RESV) supplementation (147 mg kg–1 day–1) in the third week of pregnancy could improve maternal glycaemia and protect the offspring from developing metabolic dysfunction. Female Sprague–Dawley rats consumed a high‐fat and sucrose (HFS) diet to induce GDM. Lean controls consumed a low‐fat (LF) diet. In the third trimester, when maternal hyperglycaemia was observed, the HFS diet was supplemented with RESV. At weaning, offspring were randomly assigned a LF or HFS diet until 15 weeks of age. In pregnant dams, RESV restored glucose tolerance, normoglycaemia and improved insulin secretion. At 15 weeks of age, GDM+RESV‐HFS male offspring were less obese than the GDM‐HFS offspring. By contrast, the female GDM+RESV‐HFS offspring were similarly as obese as the GDM‐HFS group. Hepatic steatosis, insulin resistance, glucose intolerance and dysregulated gluconeogenesis were observed in the male GDM offspring and were attenuated in the offspring of GDM+RESV dams. The dysregulation of several metabolic genes (e.g. ppara, lpl, pepck and g6p) in the livers of GDM offspring was attenuated in the GDM+RESV offspring group. Glucose stimulated insulin secretion was also improved in the islets from offspring of GDM+RESV dams. Thus, maternal RESV supplementation during the third trimester of pregnancy and lactation induced several beneficial metabolic health outcomes for both mothers and offspring. Therefore, RESV could be an alternative to current GDM treatments.

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Section: Discussionmentioning

confidence: 99%

Maternal resveratrol administration protects against gestational diabetes‐induced glucose intolerance and islet dysfunction in the rat offspring

Brawerman

Kereliuk

Brar

et al. 2019

The Journal of Physiology

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“…However, these studies are limited to the fetal interval, and it is not yet known if these or similar observations will hold true in the postnatal interval. It is notable that, unlike the fetal skeletal muscle, the liver (35,68) as well as the pancreas (41,69) are equally sensitive to both maternal WSD and maternal obesity; that is, maternal WSD, independent of maternal obesity, was sufficient to drive the metabolic reprogramming and alter cellular development in these fetal tissues.…”

Section: Discussionmentioning

confidence: 99%

Maternal obesity reduces oxidative capacity in fetal skeletal muscle of Japanese macaques

McCurdy¹,

Schenk²,

Hetrick³

et al. 2016

JCI Insight

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“…Aside from changes in vascular/ nerve fiber density, the capillary-associated extracellular matrix (basement membrane) is also thicker in human than rodent islets Virtanen et al 2008). A recent report stated that islets in normal human primates are "highly vascularized", based on a greater degree of CD31 (platelet endothelial cell adhesion molecule 1) immunoreactivity in endocrine versus exocrine pancreata (Pound et al 2014). The manner in which islet endothelial cells and the associated extracellular matrix interact with endocrine cells in human islets to modulate their function and survival may be different from that which occurs in rodent islets.…”

Section: Discussionmentioning

confidence: 99%

Human Islets Have Fewer Blood Vessels than Mouse Islets and the Density of Islet Vascular Structures Is Increased in Type 2 Diabetes

Shostak

Fligner

Revetta

et al. 2015

J Histochem Cytochem.

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Human and rodent islets differ substantially in several features, including architecture, cell composition, gene expression and some aspects of insulin secretion. Mouse pancreatic islets are highly vascularized with interactions between islet endothelial and endocrine cells being important for islet cell differentiation and function. To determine whether human islets have a similar high degree of vascularization and whether this is altered with diabetes, we examined the vascularization of islets from normal human subjects, subjects with type 2 diabetes (T2D), and normal mice. Using an integrated morphometry approach to quantify intra-islet capillary density in human and mouse pancreatic sections, we found that human islets have five-fold fewer vessels per islet area than mouse islets. Islets in pancreatic sections from T2D subjects showed capillary thickening, some capillary fragmentation and had increased vessel density as compared with non-diabetic controls. These changes in islet vasculature in T2D islets appeared to be associated with amyloid deposition, which was noted in islets from 8/9 T2D subjects (and occupied 14% ± 4% of islet area), especially around the intra-islet capillaries. The physiological implications of the differences in the angioarchitecture of mouse and human islets are not known. Islet vascular changes in T2D may exacerbate β cell/islet dysfunction and β cell loss.

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Consumption of a Western-style diet during pregnancy impairs offspring islet vascularization in a Japanese macaque model

Abstract: Pound LD, Comstock SM, Grove KL. Consumption of a Western-style diet during pregnancy impairs offspring islet vascularization in a Japanese macaque model.

Cited by 42 publications

References 61 publications

Maternal resveratrol administration protects against gestational diabetes‐induced glucose intolerance and islet dysfunction in the rat offspring

Maternal resveratrol administration protects against gestational diabetes‐induced glucose intolerance and islet dysfunction in the rat offspring

Maternal obesity reduces oxidative capacity in fetal skeletal muscle of Japanese macaques

Human Islets Have Fewer Blood Vessels than Mouse Islets and the Density of Islet Vascular Structures Is Increased in Type 2 Diabetes

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