Consumption of a highly palatable food induces a lasting place-conditioning memory in marmoset monkeys

Duarte, Renata B.; Patrono, Enrico; Borges, Aline Caron; César, A.A.S.; Tomaz, Carlos; Ventura, Rossella; Gasbarri, Antonella; Puglisi-Allegra, Stefano; Barros, Marília

doi:10.1016/j.beproc.2014.08.021

Cited by 14 publications

(6 citation statements)

References 24 publications

(42 reference statements)

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“…Time spent in the cocaine-paired compartment was still significantly elevated 15 days after conditioning (trial T3) with the 7 mg/kg dose, whereas pre-CPP rates were seen when the lower 3 mg/kg dose was used. Although rodents demonstrate long-lasting drug-induced CPP (reviewed in Tzschentke, 2007), in NHPs this has only been reported so far for morphine (Wang et al, 2012) and highly-palatable foods (Duarte et al, 2014). Furthermore, there was no relationship between the marmosets' cocaine-induced CPP and hypervigilance, similar to reports in rodents (Brabant et al, 2005;Orsini et al, 2005;Seymour and Wagner, 2008).…”

Section: Discussionmentioning

confidence: 65%

“…In fact, it has become an increasingly prevalent procedure to evaluate aspects of addiction-like behaviors (Tzschentke, 2007). Although commonly reported in rodents, the CPP paradigm has only recently been demonstrated in NHPs using both drug- Foltin and Evans, 2001;Wang et al, 2012) and food-related stimuli (Duarte et al, 2014;Foltin and Evans, 2002;Monclaro et al, 2014;Valentinuzzi et al, 2008). As the outcome in rodents can be significantly influenced by several factors, including drug dose, injection-conditioning interval, duration of the conditionings and number of drug-pairings (reviewed in Tzschentke, 2007), a more detailed evaluation in NHPs is warranted.…”

Section: Introductionmentioning

confidence: 99%

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Temporal and dose-dependent differences in simultaneously-induced cocaine hypervigilance and conditioned-place-preference in marmoset monkeys

Borges

Duarte

Nogueira

et al. 2015

Drug and Alcohol Dependence

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Section: Discussionmentioning

confidence: 65%

Section: Introductionmentioning

confidence: 99%

Temporal and dose-dependent differences in simultaneously-induced cocaine hypervigilance and conditioned-place-preference in marmoset monkeys

Borges

Duarte

Nogueira

et al. 2015

Drug and Alcohol Dependence

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“…Such behavior leads to the prevalence of eating disorders such as obesity and binge eating disorder (BED). Recent studies suggest that BED shows specific features involving uncontrolled compulsive food consumption and feelings of loss of control over eating behavior ( American Psychiatric Association, 2013 ), underlined by neurobiological features of dysfunctional cognitive control, food addiction, and gene–environment interactions posing as risk factors ( Latagliata et al, 2010 ; Patrono et al, 2015 , 2016 ; Duarte et al, 2014 , 2015 ). Studies have shown that a low availability of dopamine D2 receptors (DA D2Rs) in the nucleus accumbens (NA) is a genetic risk factor for chocolate compulsive-seeking behavior, which is also mediated by stressful environments ( Hoebel et al, 2009 ; Campbell et al, 2010 ; Kenny, 2011 ; Di Segni et al, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

Rewarding Effects of Operant Dry-Licking Behavior on Neuronal Firing in the Nucleus Accumbens Core

et al. 2017

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Certain eating behaviors are characterized by a trend of elevated food consumption. However, neural mechanisms mediating the motivation for food consumption are not fully understood. Food impacts the brain-rewarding-system via both oral-sensory and post-ingestive information. Recent studies have reported an important role of visceral gut information in mediating dopamine (DA) release in the brain rewarding system. This is independent of oral sensation, suggesting a role of the gut-brain-DA-axis in feeding behavior. In this study, we investigated the effects of intra-gastric (IG) self-administration of glucose on neuronal firings in the nucleus accumbens (NA) of water-deprived rats. Rats were trained in an operant-licking paradigm. During training, when the light was on for 2 min (light-period), rats were required to lick a spout to acquire the water oral-intake learning, and either an IG self-infusion of 0.4 M glucose (GLU group) or water (H2O group). Rats rested in the dark-period (3 min) following the light-period. Four cycles of the operant-licking paradigm consisting of the light–dark periods were performed per day, for 4 consecutive days. In the test session, the same rats licked the same spout to acquire the IG self-administration of the corresponding solutions, without oral water ingestion (dry licking). Behavioral results indicated IG self-administration of glucose elicits more dry-licking behavior than that of water. Neurophysiological results indicated in the dark period, coefficient of variance (CV) measuring the inter-spike interval variability of putative medial spiny neurons (pMSNs) in the NA was reduced in the H2O group compared to the GLU group, while there was no significant difference in physical behaviors in the dark period between the two groups. Since previous studies reported that DA release increases CV of MSNs, the present results suggest that greater CV of pMSNs in the GLU group reflects greater DA release in the NA and elevated motivation in the GLU group, which might increase lickings in the test session in the GLU group compared to the H2O group.

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“…It has been suggested that entries into the paired compartment may represent seeking behavior which can be distinguished from the reward memory measured with the preference score (Duarte et al, 2014;Sun et al, 2017). In the present study, there were no overall group differences between entries but there was a significant interaction between food type and entries into the paired side and unpaired side.…”

Section: Discussioncontrasting

confidence: 53%

Evaluating Time-Dependent Changes in Food Seeking Following Periods of Forced Abstinence and Associated Changes in the Nucleus Accumbens

Tuplin¹,

Wendy²

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Incubation of craving is a phenomenon whereby responding for cues associated with reward (food and drugs) increases over extended periods of abstinence. Evaluating the mechanisms of food craving has implications in understanding how consumption of foods high in certain macronutrients (fat, sugar) may contribute to continued cravings and subsequent weight gain. The primary goals of this thesis were to examine if forced abstinence from different food rewards resulted in a continued/or delayed craving response by utilizing different behavioral designs (contingent vs non-contingent) and examining associated changes in nucleus accumbens (NAc) immediate early genes, dendritic spine density, and AMPA receptor protein expression. Food self-administration (operant conditioning), classical conditioning, and conditioned place preference (CPP) were utilize for the investigation of incubation of food craving. Abstinence from selfadministration of purified food pellets was the only food group to display an incubation of craving response. Self-administration of chocolate flavored pellet, sucrose, or chocolate sucrose pellets did not result in an incubation response but did result in consistent responding at all abstinence periods which was associated with elevated dendritic spine density for chocolate flavored pellets. The type of behavioral design affected association FosB labelling as rats that underwent classical conditioning displayed significantly lower FosB in the NAc compared to operant trained rats and food restricted controls. CPP for chocolate flavored pellets or milk chocolate chips showed that the type of food reward can affect the possibility of a place preference response, milk chocolate did not produce CPP. The CPP model was unable to produce an incubation of craving response which may have resulted from the rewarding properties of the food choice and number of training sessions. Exposure to rewarding cues rapidly increased GluR1 expression, but this was not specifically associated with an incubation of craving response, thus the functional significance has yet to be elucidated. The present thesis has highlighted that foods of different macronutrient composition and/or flavors and the use of different behavioral designs can affect the potential for an incubation of craving response and associated NAc changes.

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Consumption of a highly palatable food induces a lasting place-conditioning memory in marmoset monkeys

Cited by 14 publications

References 24 publications

Temporal and dose-dependent differences in simultaneously-induced cocaine hypervigilance and conditioned-place-preference in marmoset monkeys

Temporal and dose-dependent differences in simultaneously-induced cocaine hypervigilance and conditioned-place-preference in marmoset monkeys

Rewarding Effects of Operant Dry-Licking Behavior on Neuronal Firing in the Nucleus Accumbens Core

Evaluating Time-Dependent Changes in Food Seeking Following Periods of Forced Abstinence and Associated Changes in the Nucleus Accumbens

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