Construction of recombinant Omp25 or EipB protein loaded PLGA nanovaccines for Brucellosis protection
Ilkgul Akmayan,
Sedanur Oztav,
Irem Coksu
et al.
Abstract:Safe and effective vaccine candidates are needed to address the limitations of existing vaccines against Brucellosis, a disease responsible for substantial economic losses in livestock. The present study aimed to encapsulate Omp25 and EipB proteins, knowledged antigen properties, into PLGA nanoparticles, characterize synthesized nanoparticles with different methods, and assessed their in vitro/in vivo immunostimulatory activities to develop new vaccine candidates. The rOmp25 and EipB proteins produced with re… Show more
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