Construction of GSH-triggered cationic fluoropolymers as two-in-one nanoplatforms for combined chemo-gene therapy

Yu, Xiao‐Qi; Zhan, Yu-Rong; Tan, Juan; Hei, Meng-Wei; Zhang, Shiyong; Zhang, Ji

doi:10.1039/d1tb02602j

Cited by 10 publications

(8 citation statements)

References 56 publications

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“…The recovery of the expression of the cancer suppressor gene in combination with chemotherapy can reverse drug resistance in cancer cells to reach an augmented therapeutic effect. Zhan et al 844 synthesized a GSH‐responsive cationic fluoropolymer PSSF to codelivery of p53 gene and chemotherapeutic drug DOX. The synthesized PSSF could deliver the p53 gene into cells with good protein expression and realize fast release of DOX into Hela cells.…”

Section: Cancer Therapies Using Npsmentioning

confidence: 99%

Advances and applications of nanoparticles in cancer therapy

Huang,

He,

Liang

et al. 2024

MedComm – Oncology

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Rapid growth in nanoparticles (NPs) as delivery systems holds vast promise to promote therapeutic approaches for cancer treatment. Presently, a diverse array of NPs with unique properties have been developed to overcome different challenges and to achieve sophisticated delivery routes for enhancement of a series of therapies. Inspiring advances have been achieved in the field of cancer therapy using NPs. In this review, we aim to summarize the up‐to‐date progression of NPs for addressing various challenges, and expect to elicit novel and potential opportunities alternatively. We first introduce different sorts of NP technologies, illustrate their mechanisms, and present their applications. Then, the achievements made by NPs to break obstacles in delivering cargoes to specific sites through particular routes are highlighted, including long‐circulation, tumor targeting, responsive release, and subcellular localization. We subsequently retrospect recent research of NPs in different cancer treatments from single therapy, like chemotherapy, to combination therapy, like chemoradiotherapy, and to integrative therapy. Finally, the challenges and perspectives of NPs in cancer therapy, and their potential impact on the field of oncology are discussed. We believe this review can offer a deeper understanding of the challenges and opportunities of NPs for cancer therapy.

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Section: Cancer Therapies Using Npsmentioning

confidence: 99%

Advances and applications of nanoparticles in cancer therapy

Huang,

He,

Liang

et al. 2024

MedComm – Oncology

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“…Zhan et al proposed an innovative solution in their study, by designing a novel GSH-responsive fluorinated cationic polymer PSSF as a co-delivery platform for DOX and p53 gene (Figure 21a). [113] PSSF was synthesized by introducing perfluorinated chains through disulfide bonds into low-molecular weight PEI-based cationic polymers, showing a good ability to load drugs and genes. Compared to traditional high-molecular weight PEI (25 kDa), this nanoplatform demonstrates higher gene transfection efficiency and can also increase the expression level of p53 protein in HeLa cells (Figure 21b).…”

Section: Fluorinated Polymers-mediated Synergistic Cancer Therapymentioning

confidence: 99%

Fluorinated Organic Polymers for Cancer Drug Delivery

Xin,

Lu,

Cao

et al. 2024

Advanced Materials

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In the realm of cancer therapy, the spotlight is on nanoscale pharmaceutical delivery systems, especially polymer‐based nanoparticles, for their enhanced drug dissolution, extended presence in the bloodstream, and precision targeting achieved via surface engineering. Leveraging the amplified permeation and retention phenomenon, these systems concentrate therapeutic agents within tumor tissues. Nonetheless, the hurdles of systemic toxicity, biological barriers, and compatibility with living systems persist. Fluorinated polymers, distinguished by their chemical idiosyncrasies, are poised for extensive biomedical applications, notably in stabilizing drug metabolism, augmenting lipophilicity, and optimizing bioavailability. Material science heralds the advent of fluorinated polymers that, by integrating fluorine atoms, unveil a suite of drug delivery merits: the hydrophobic traits of fluorinated alkyl chains ward off lipid or protein disruption, the carbon‐fluorine bond's stability extends the drug's lifecycle in the system, and a lower alkalinity coupled with a diminished ionic charge bolsters the drug's ability to traverse cellular membranes. This comprehensive review delves into the utilization of fluorinated polymers for oncological pharmacotherapy, elucidating their molecular architecture, synthetic pathways, and functional attributes, alongside an exploration of their empirical strengths and the quandaries they encounter in both experimental and clinical settings.This article is protected by copyright. All rights reserved

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“…Owing to the enhanced permeability and retention (EPR) effect, nanoparticles can effectively accumulate at tumor sites in which the physiological environment is abnormal. Moreover, the tumor always has distinct environments from normal tissues, thus giving an opportunity to construct stimuli-responsive delivery systems and achieve cargo release in response to acid, , hypoxia, , enzymes, , or redox. − …”

Section: Introductionmentioning

confidence: 99%

Lipoic Acid-Based Poly(disulfide)s as Versatile Biomolecule Delivery Vectors and the Application in Tumor Immunotherapy

et al. 2023

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Intracellular delivery of therapeutic biomacromolecules, including nucleic acids and proteins, attracts extensive attention in biotherapeutics for various diseases. Herein, a strategy is proposed for the construction of poly(disulfide)s for the efficient delivery of both nucleic acids and proteins into cells. A convenient photo-cross-linking polymerization was adopted between disulfide bonds in two modified lipoic acid monomers (Zn coordinated with dipicolylamine analogue (ZnDPA) and guanidine (GUA)). The disulfide-containing main chain of the resulting poly(disulfide)s was responsive to reducing circumstance, facilitating the release of cargos. By screening the feeding ratio of ZnDPA and GUA, the resulting poly(disulfide)s exhibited better performance in the delivery of nucleic acids including plasmid DNA and siRNA than commercially available transfection reagents. Cellular uptake results revealed that the polymer/cargo complexes entered the cells mainly following a thiolmediated uptake pathway. Meanwhile, the polymer could also efficiently deliver proteins into cells without an obvious loss of protein activity, showing the versatility of the poly(disulfide)s for the delivery of various biomacromolecules. Moreover, the in vivo therapeutic effect of the materials was verified in the E.G7-OVA tumor-bearing mice. Ovalbumin-based nanovaccine induced a strong cellular immune response, especially cytotoxic T lymphocyte cellular immune response, and inhibited tumor growth. These results revealed the promise of the poly(disulfide)s in the application of both gene therapy and immunotherapy.

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Construction of GSH-triggered cationic fluoropolymers as two-in-one nanoplatforms for combined chemo-gene therapy

Abstract: The combined chemo-gene therapy has become a promising approach for enhanced anti-cancer treatment. However, effective co-delivery of therapeutic gene and drug into target cells and tissues remains a major obstacle....

Cited by 10 publications

References 56 publications

Advances and applications of nanoparticles in cancer therapy

Advances and applications of nanoparticles in cancer therapy

Fluorinated Organic Polymers for Cancer Drug Delivery

Lipoic Acid-Based Poly(disulfide)s as Versatile Biomolecule Delivery Vectors and the Application in Tumor Immunotherapy

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